Browse GABRP

Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Domain PF02931 Neurotransmitter-gated ion-channel ligand binding domain
PF02932 Neurotransmitter-gated ion-channel transmembrane region
Function

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.

> Gene Ontology
 
Biological Process GO:0006820 anion transport
GO:0006821 chloride transport
GO:0015698 inorganic anion transport
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1902476 chloride transmembrane transport
Molecular Function GO:0004890 GABA-A receptor activity
GO:0005216 ion channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005231 excitatory extracellular ligand-gated ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005253 anion channel activity
GO:0005254 chloride channel activity
GO:0008068 extracellular-glutamate-gated chloride channel activity
GO:0008509 anion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0016917 GABA receptor activity
GO:0022803 passive transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
Cellular Component GO:0034702 ion channel complex
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098794 postsynapse
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04723 Retrograde endocannabinoid signaling
hsa04727 GABAergic synapse
Reactome -
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GABRP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GABRP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GABRP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.0250.0277
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.10.894
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.7250.004
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.4840.0196
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.6180.349
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.310.522
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0170.982
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.5840.602
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6070.607
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4970.482
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2160.822
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3710.425
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GABRP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GABRP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GABRP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GABRP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GABRP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GABRP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GABRP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGABRP
Namegamma-aminobutyric acid (GABA) A receptor, pi
Aliases GABA(A) receptor, pi; GABA(A) receptor subunit pi; Gamma-aminobutyric acid receptor subunit pi
Chromosomal Location5q35.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GABRP collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GABRP.
ID Name Drug Type Targets #Targets
DB00186LorazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00189EthchlorvynolSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00228EnfluraneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GAB ......23
DB00231TemazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00231TemazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00237ButabarbitalSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GA ......20
DB00241ButalbitalSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......26
DB00273TopiramateSmall MoleculeCA1, CA2, CA3, CA4, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5 ......23
DB00292EtomidateSmall MoleculeADRA2B, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GA ......18
DB00306TalbutalSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......26
DB00312PentobarbitalSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......34
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00349ClobazamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00371MeprobamateSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......22
DB00402EszopicloneSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......20
DB00404AlprazolamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00463MetharbitalSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......26
DB00475ChlordiazepoxideSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00546AdinazolamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GAB ......16
DB00555LamotrigineSmall MoleculeADORA1, ADORA2A, ADRA1A, ADRA2A, ADRB1, CACNA1E, CHRM1, CHRM2, CHR ......44
DB00628ClorazepateSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......16
DB00659AcamprosateSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......24
DB00683MidazolamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......19
DB00690FlurazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......19
DB00753IsofluraneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GAB ......22
DB00794PrimidoneSmall MoleculeCHRNA4, CHRNA7, GABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GA ......26
DB00801HalazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB00801HalazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB00818PropofolSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......20
DB00829DiazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......33
DB00829DiazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......33
DB00842OxazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00842OxazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00897TriazolamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00897TriazolamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA4, GA ......35
DB00898EthanolSmall MoleculeCACNA1C, CACNA1D, CACNA1S, CACNB1, CACNG1, CACNG2, CHRNA10, CHRNA2 ......52
DB01028MethoxyfluraneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GAB ......23
DB01049Ergoloid mesylateSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......41
DB01068ClonazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......17
DB01107MethyprylonSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GA ......17
DB01159HalothaneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GAB ......33
DB01189DesfluraneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GAB ......22
DB01205FlumazenilSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA5, GABRA6, GA ......19
DB01215EstazolamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB01215EstazolamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB01236SevofluraneSmall MoleculeATP2C1, ATP5D, GABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GAB ......23
DB01437GlutethimideSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GA ......17
DB01558BromazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......19
DB01559ClotiazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GAB ......16
DB01567FludiazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GAB ......16
DB01588PrazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB01588PrazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......32
DB01589QuazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......31
DB01589QuazepamSmall MoleculeGABRA1, GABRA1, GABRA2, GABRA2, GABRA3, GABRA3, GABRA4, GABRA5, GA ......31
DB01594CinolazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA5, GABRB1, GABRB2, GABRB3, GABRD, GAB ......16
DB01595NitrazepamSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......20
DB01708PrasteroneSmall MoleculeAR, ESR1, ESR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GA ......33
DB01956TaurineSmall MoleculeGABBR1, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GA ......21
DB09118StiripentolSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......18
DB11582ThiocolchicosideSmall MoleculeGABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GA ......18
DB11901ApalutamideSmall MoleculeAR, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2 ......17