TISIDB

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	-
Domain	PF01248 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Function	Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

> Gene Ontology [ TOP ]
Biological Process	GO:0000185 activation of MAPKKK activity GO:0007254 JNK cascade GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0032872 regulation of stress-activated MAPK cascade GO:0032874 positive regulation of stress-activated MAPK cascade GO:0033674 positive regulation of kinase activity GO:0038066 p38MAPK cascade GO:0043405 regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0045860 positive regulation of protein kinase activity GO:0046328 regulation of JNK cascade GO:0046330 positive regulation of JNK cascade GO:0051403 stress-activated MAPK cascade GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070304 positive regulation of stress-activated protein kinase signaling cascade GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:1900744 regulation of p38MAPK cascade GO:1900745 positive regulation of p38MAPK cascade
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04068 FoxO signaling pathway hsa04110 Cell cycle hsa04115 p53 signaling pathway hsa04210 Apoptosis
Reactome	-

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GADD45G and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between GADD45G and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
19688743	Melanoma	Promote immunity (T cell function)	Gadd45b and Gadd45g are important for anti-tumor immune responses.

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of GADD45G in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of GADD45G in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.143	0.8
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.595	0.653
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.189	0.855
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.187	0.684
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.262	0.805
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.756	0.555
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.193	0.749
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.692	0.44
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.493	0.593
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.501	0.652
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.631	0.678
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.106	0.537

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of GADD45G in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	1

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GADD45G. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GADD45G. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GADD45G. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GADD45G. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GADD45G expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GADD45G and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GADD45G
Name	growth arrest and DNA-damage-inducible, gamma
Aliases	DDIT2; GADD45gamma; GRP17; CR6; gadd-related protein, 17 kD; growth arrest and DNA-damage-inducible gamma; D ......
Chromosomal Location	9q22.1-q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GADD45G collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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