TISIDB

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane; Multi-pass membrane protein.
Domain	PF00002 7 transmembrane receptor (Secretin family) PF02793 Hormone receptor domain
Function	Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

> Gene Ontology [ TOP ]
Biological Process	GO:0001678 cellular glucose homeostasis GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002793 positive regulation of peptide secretion GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007190 activation of adenylate cyclase activity GO:0007568 aging GO:0007589 body fluid secretion GO:0007595 lactation GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0008340 determination of adult lifespan GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009755 hormone-mediated signaling pathway GO:0009914 hormone transport GO:0010259 multicellular organism aging GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0021536 diencephalon development GO:0021700 developmental maturation GO:0021983 pituitary gland development GO:0021984 adenohypophysis development GO:0022410 circadian sleep/wake cycle process GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030104 water homeostasis GO:0030252 growth hormone secretion GO:0030431 sleep GO:0030518 intracellular steroid hormone receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0030879 mammary gland development GO:0030900 forebrain development GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0031960 response to corticosteroid GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032941 secretion by tissue GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway GO:0033500 carbohydrate homeostasis GO:0034284 response to monosaccharide GO:0035264 multicellular organism growth GO:0035270 endocrine system development GO:0040014 regulation of multicellular organism growth GO:0040018 positive regulation of multicellular organism growth GO:0042445 hormone metabolic process GO:0042593 glucose homeostasis GO:0042745 circadian sleep/wake cycle GO:0042748 circadian sleep/wake cycle, non-REM sleep GO:0042749 regulation of circadian sleep/wake cycle GO:0042752 regulation of circadian rhythm GO:0042753 positive regulation of circadian rhythm GO:0042886 amide transport GO:0043401 steroid hormone mediated signaling pathway GO:0043434 response to peptide hormone GO:0043567 regulation of insulin-like growth factor receptor signaling pathway GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043627 response to estrogen GO:0044708 single-organism behavior GO:0045187 regulation of circadian sleep/wake cycle, sleep GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045927 positive regulation of growth GO:0045938 positive regulation of circadian sleep/wake cycle, sleep GO:0045981 positive regulation of nucleotide metabolic process GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046887 positive regulation of hormone secretion GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048520 positive regulation of behavior GO:0048545 response to steroid hormone GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048732 gland development GO:0050795 regulation of behavior GO:0050802 circadian sleep/wake cycle, sleep GO:0050878 regulation of body fluid levels GO:0051047 positive regulation of secretion GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051384 response to glucocorticoid GO:0052652 cyclic purine nucleotide metabolic process GO:0060123 regulation of growth hormone secretion GO:0060124 positive regulation of growth hormone secretion GO:0060126 somatotropin secreting cell differentiation GO:0060133 somatotropin secreting cell development GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071383 cellular response to steroid hormone stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0072522 purine-containing compound biosynthetic process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090277 positive regulation of peptide hormone secretion GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903532 positive regulation of secretion by cell
Molecular Function	GO:0016520 growth hormone-releasing hormone receptor activity GO:0017046 peptide hormone binding GO:0019838 growth factor binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042562 hormone binding
Cellular Component	GO:0005635 nuclear envelope GO:0005637 nuclear inner membrane GO:0005640 nuclear outer membrane GO:0016363 nuclear matrix GO:0019867 outer membrane GO:0030141 secretory granule GO:0031965 nuclear membrane GO:0031968 organelle outer membrane GO:0034399 nuclear periphery GO:0042383 sarcolemma GO:0099503 secretory vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04080 Neuroactive ligand-receptor interaction
Reactome	R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-420092: Glucagon-type ligand receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GHRHR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of GHRHR in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA	Resistant to T cell-mediated killing
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of GHRHR in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0	1
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0	1
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0	1
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.36	0.124
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-3.121	0.0109
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.845	0.56
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0	1
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0	1
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0	1
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0	1
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0	1
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.004	0.99

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of GHRHR in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	7.1	-7.1	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	1.4	6	0.177
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	7.1	-7.1	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	0	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	6.2	4.9	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	11.1	8.9	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GHRHR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GHRHR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GHRHR. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GHRHR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GHRHR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GHRHR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GHRHR
Name	growth hormone releasing hormone receptor
Aliases	GHRFR; GRFR; GHRH receptor; GRF receptor; Growth hormone-releasing factor receptor; Growth hormone-releasing ......
Chromosomal Location	7p14
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GHRHR collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting GHRHR.

ID	Name	Drug Type	Targets	#Targets
DB00010	Sermorelin	Biotech	GHRHR	1
DB08869	Tesamorelin	Small Molecule	GHRHR	1

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