Browse GIPR

Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00002 7 transmembrane receptor (Secretin family)
PF02793 Hormone receptor domain
Function

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0006091 generation of precursor metabolites and energy
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0007190 activation of adenylate cyclase activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007584 response to nutrient
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010817 regulation of hormone levels
GO:0015833 peptide transport
GO:0022401 negative adaptation of signaling pathway
GO:0023058 adaptation of signaling pathway
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0031667 response to nutrient levels
GO:0032024 positive regulation of insulin secretion
GO:0034284 response to monosaccharide
GO:0035270 endocrine system development
GO:0038192 gastric inhibitory peptide signaling pathway
GO:0042886 amide transport
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
GO:0045761 regulation of adenylate cyclase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048678 response to axon injury
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051047 positive regulation of secretion
GO:0051222 positive regulation of protein transport
GO:0051339 regulation of lyase activity
GO:0051349 positive regulation of lyase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0052652 cyclic purine nucleotide metabolic process
GO:0055074 calcium ion homeostasis
GO:0070542 response to fatty acid
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072522 purine-containing compound biosynthetic process
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0016519 gastric inhibitory peptide receptor activity
GO:0017046 peptide hormone binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0042562 hormone binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
Reactome R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-420092: Glucagon-type ligand receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GIPR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GIPR in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GIPR in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2520.228
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.210.617
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2820.424
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3150.405
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.9370.476
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4740.756
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1450.0524
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15112.3350.0219
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1510.893
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3850.331
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.590.307
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7190.000134
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GIPR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GIPR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GIPR.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GIPR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GIPR expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GIPR and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGIPR
Namegastric inhibitory polypeptide receptor
Aliases PGQTL2; GIP-R; glucose-dependent insulinotropic polypeptide receptor
Chromosomal Location19q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GIPR collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.