Summary | |
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Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion outer membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Note=In sperm the majority of the enzyme is bound to mitochondria. |
Domain |
PF02782 FGGY family of carbohydrate kinases PF00370 FGGY family of carbohydrate kinases |
Function |
Key enzyme in the regulation of glycerol uptake and metabolism. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006071 glycerol metabolic process GO:0006072 glycerol-3-phosphate metabolic process GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0016052 carbohydrate catabolic process GO:0019400 alditol metabolic process GO:0019405 alditol catabolic process GO:0019563 glycerol catabolic process GO:0019751 polyol metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044275 cellular carbohydrate catabolic process GO:0044282 small molecule catabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0046164 alcohol catabolic process GO:0046167 glycerol-3-phosphate biosynthetic process GO:0046174 polyol catabolic process GO:0046486 glycerolipid metabolic process GO:0052646 alditol phosphate metabolic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process |
Molecular Function |
GO:0004370 glycerol kinase activity |
Cellular Component |
GO:0005741 mitochondrial outer membrane GO:0019867 outer membrane GO:0031968 organelle outer membrane |
KEGG |
hsa03320 PPAR signaling pathway hsa00561 Glycerolipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GK2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GK2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GK2 in various data sets.
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Points in the above scatter plot represent the mutation difference of GK2 in various data sets.
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Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GK2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GK2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GK2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GK2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GK2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GK2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GK2 |
Name | glycerol kinase 2 |
Aliases | GKTA; GKP2; glycerol kinase pseudogene 2; ATP:glycerol 3-phosphotransferase 2; glycerokinase 2; glycerol kin ...... |
Chromosomal Location | 4q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GK2 collected from DrugBank database. |
There is no record. |