Browse GLI3

Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Cell projection, cilium. Note=GLI3FL is localized predominantly in the cytoplasm while GLI3R resides mainly in the nucleus. Ciliary accumulation requires the presence of KIF7 and SMO. Translocation to the nucleus is promoted by interaction with ZIC1.
Domain -
Function

Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001654 eye development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001701 in utero embryonic development
GO:0001708 cell fate specification
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002052 positive regulation of neuroblast proliferation
GO:0002062 chondrocyte differentiation
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0003002 regionalization
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007224 smoothened signaling pathway
GO:0007389 pattern specification process
GO:0007405 neuroblast proliferation
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007423 sensory organ development
GO:0007442 hindgut morphogenesis
GO:0007507 heart development
GO:0008347 glial cell migration
GO:0008589 regulation of smoothened signaling pathway
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010001 glial cell differentiation
GO:0010092 specification of animal organ identity
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0016055 Wnt signaling pathway
GO:0016485 protein processing
GO:0017038 protein import
GO:0021510 spinal cord development
GO:0021511 spinal cord patterning
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021514 ventral spinal cord interneuron differentiation
GO:0021515 cell differentiation in spinal cord
GO:0021517 ventral spinal cord development
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021521 ventral spinal cord interneuron specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021532 neural tube patterning
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021545 cranial nerve development
GO:0021554 optic nerve development
GO:0021602 cranial nerve morphogenesis
GO:0021631 optic nerve morphogenesis
GO:0021675 nerve development
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021795 cerebral cortex cell migration
GO:0021798 forebrain dorsal/ventral pattern formation
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021801 cerebral cortex radial glia guided migration
GO:0021819 layer formation in cerebral cortex
GO:0021846 cell proliferation in forebrain
GO:0021861 forebrain radial glial cell differentiation
GO:0021871 forebrain regionalization
GO:0021872 forebrain generation of neurons
GO:0021885 forebrain cell migration
GO:0021904 dorsal/ventral neural tube patterning
GO:0021910 smoothened signaling pathway involved in ventral spinal cord patterning
GO:0021915 neural tube development
GO:0021953 central nervous system neuron differentiation
GO:0021987 cerebral cortex development
GO:0022012 subpallium cell proliferation in forebrain
GO:0022018 lateral ganglionic eminence cell proliferation
GO:0022029 telencephalon cell migration
GO:0022030 telencephalon glial cell migration
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022612 gland morphogenesis
GO:0030098 lymphocyte differentiation
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030217 T cell differentiation
GO:0030278 regulation of ossification
GO:0030318 melanocyte differentiation
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030879 mammary gland development
GO:0030900 forebrain development
GO:0032330 regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0033077 T cell differentiation in thymus
GO:0033157 regulation of intracellular protein transport
GO:0034504 protein localization to nucleus
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035239 tube morphogenesis
GO:0042063 gliogenesis
GO:0042110 T cell activation
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0043383 negative T cell selection
GO:0043473 pigmentation
GO:0043583 ear development
GO:0043584 nose development
GO:0043585 nose morphogenesis
GO:0043586 tongue development
GO:0043627 response to estrogen
GO:0044744 protein targeting to nucleus
GO:0045058 T cell selection
GO:0045060 negative thymic T cell selection
GO:0045061 thymic T cell selection
GO:0045165 cell fate commitment
GO:0045580 regulation of T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045667 regulation of osteoblast differentiation
GO:0045669 positive regulation of osteoblast differentiation
GO:0045778 positive regulation of ossification
GO:0045785 positive regulation of cell adhesion
GO:0045879 negative regulation of smoothened signaling pathway
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046634 regulation of alpha-beta T cell activation
GO:0046635 positive regulation of alpha-beta T cell activation
GO:0046636 negative regulation of alpha-beta T cell activation
GO:0046637 regulation of alpha-beta T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046639 negative regulation of alpha-beta T cell differentiation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0048066 developmental pigmentation
GO:0048546 digestive tract morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048566 embryonic digestive tract development
GO:0048568 embryonic organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048645 animal organ formation
GO:0048663 neuron fate commitment
GO:0048665 neuron fate specification
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048709 oligodendrocyte differentiation
GO:0048732 gland development
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048839 inner ear development
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0050870 positive regulation of T cell activation
GO:0050931 pigment cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051604 protein maturation
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0055123 digestive system development
GO:0060019 radial glial cell differentiation
GO:0060021 palate development
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060363 cranial suture morphogenesis
GO:0060364 frontal suture morphogenesis
GO:0060366 lambdoid suture morphogenesis
GO:0060367 sagittal suture morphogenesis
GO:0060443 mammary gland morphogenesis
GO:0060541 respiratory system development
GO:0060562 epithelial tube morphogenesis
GO:0060573 cell fate specification involved in pattern specification
GO:0060579 ventral spinal cord interneuron fate commitment
GO:0060581 cell fate commitment involved in pattern specification
GO:0060592 mammary gland formation
GO:0060594 mammary gland specification
GO:0060675 ureteric bud morphogenesis
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0060840 artery development
GO:0060872 semicircular canal development
GO:0060873 anterior semicircular canal development
GO:0060875 lateral semicircular canal development
GO:0060993 kidney morphogenesis
GO:0061005 cell differentiation involved in kidney development
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061138 morphogenesis of a branching epithelium
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061351 neural precursor cell proliferation
GO:0061448 connective tissue development
GO:0061525 hindgut development
GO:0061564 axon development
GO:0070227 lymphocyte apoptotic process
GO:0070231 T cell apoptotic process
GO:0070242 thymocyte apoptotic process
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071593 lymphocyte aggregation
GO:0071594 thymocyte aggregation
GO:0071887 leukocyte apoptotic process
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090316 positive regulation of intracellular protein transport
GO:0090596 sensory organ morphogenesis
GO:0097094 craniofacial suture morphogenesis
GO:0097485 neuron projection guidance
GO:0198738 cell-cell signaling by wnt
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902593 single-organism nuclear import
GO:1902692 regulation of neuroblast proliferation
GO:1903010 regulation of bone development
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903533 regulation of protein targeting
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904888 cranial skeletal system development
GO:1904951 positive regulation of establishment of protein localization
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000648 positive regulation of stem cell proliferation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0008013 beta-catenin binding
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
Cellular Component GO:0005929 cilium
GO:0005930 axoneme
GO:0016592 mediator complex
GO:0016604 nuclear body
GO:0016607 nuclear speck
GO:0017053 transcriptional repressor complex
GO:0044441 ciliary part
GO:0072372 primary cilium
GO:0097014 ciliary plasm
GO:0097542 ciliary tip
GO:0097546 ciliary base
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04340 Hedgehog signaling pathway
Reactome R-HSA-5635851: GLI proteins bind promoters of Hh responsive genes to promote transcription
R-HSA-5610785: GLI3 is processed to GLI3R by the proteasome
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5632684: Hedgehog 'on' state
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GLI3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GLI3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GLI3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3740.386
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6050.655
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2070.844
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3050.414
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0970.965
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8190.754
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0950.826
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.30.846
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6240.697
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0680.924
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8890.319
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6150.000148
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GLI3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLI3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLI3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLI3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLI3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GLI3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GLI3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGLI3
NameGLI family zinc finger 3
Aliases PAP-A; PAPA1; PAPB; PPDIV; zinc finger protein GLI3; oncogene GLI3; GCPS; Greig cephalopolysyndactyly syndro ......
Chromosomal Location7p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GLI3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.