Browse GNA11

Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasm Note=In testicular cells, expressed exclusively in the cytoplasm.
Domain PF00503 G-protein alpha subunit
Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001508 action potential
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0007602 phototransduction
GO:0007603 phototransduction, visible light
GO:0007623 circadian rhythm
GO:0009268 response to pH
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009581 detection of external stimulus
GO:0009582 detection of abiotic stimulus
GO:0009583 detection of light stimulus
GO:0009584 detection of visible light
GO:0009649 entrainment of circadian clock
GO:0030168 platelet activation
GO:0030318 melanocyte differentiation
GO:0042391 regulation of membrane potential
GO:0042752 regulation of circadian rhythm
GO:0043473 pigmentation
GO:0045634 regulation of melanocyte differentiation
GO:0048066 developmental pigmentation
GO:0048070 regulation of developmental pigmentation
GO:0048511 rhythmic process
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0050931 pigment cell differentiation
GO:0050932 regulation of pigment cell differentiation
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060359 response to ammonium ion
GO:0071214 cellular response to abiotic stimulus
GO:0071242 cellular response to ammonium ion
GO:0071467 cellular response to pH
GO:0095500 acetylcholine receptor signaling pathway
GO:1903831 signal transduction involved in cellular response to ammonium ion
GO:1905144 response to acetylcholine
GO:1905145 cellular response to acetylcholine
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031821 G-protein coupled serotonin receptor binding
GO:0031826 type 2A serotonin receptor binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0001750 photoreceptor outer segment
GO:0005765 lysosomal membrane
GO:0005929 cilium
GO:0031513 nonmotile primary cilium
GO:0072372 primary cilium
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04270 Vascular smooth muscle contraction
hsa04540 Gap junction
hsa04725 Cholinergic synapse
hsa04730 Long-term depression
hsa04911 Insulin secretion
hsa04912 GnRH signaling pathway
Reactome R-HSA-418592: ADP signalling through P2Y purinoceptor 1
R-HSA-399997: Acetylcholine regulates insulin secretion
R-HSA-434316: Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-HSA-400451: Free fatty acids regulate insulin secretion
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-109582: Hemostasis
R-HSA-163685: Integration of energy metabolism
R-HSA-1430728: Metabolism
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-422356: Regulation of insulin secretion
R-HSA-162582: Signal Transduction
R-HSA-392518: Signal amplification
R-HSA-372790: Signaling by GPCR
R-HSA-456926: Thrombin signalling through proteinase activated receptors (PARs)
R-HSA-428930: Thromboxane signalling through TP receptor
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GNA11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GNA11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 4.72; FDR: 0.006 Resistant to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GNA11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0840.716
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0950.966
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0740.963
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2650.411
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0910.963
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4840.845
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1010.708
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1190.92
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0760.955
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2620.858
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1780.566
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0710.209
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GNA11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNA11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNA11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNA11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNA11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GNA11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GNA11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGNA11
Nameguanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Aliases FBH; FBH2; FHH2; HHC2; hypocalciuric hypercalcemia 2; GNA-11; HYPOC2; G-protein subunit alpha-11; g alpha-11 ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GNA11 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.