Browse GNRH1

Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00446 Gonadotropin-releasing hormone
Function

Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones.

> Gene Ontology
 
Biological Process GO:0001541 ovarian follicle development
GO:0001764 neuron migration
GO:0002237 response to molecule of bacterial origin
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007530 sex determination
GO:0007548 sex differentiation
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008406 gonad development
GO:0008585 female gonad development
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010721 negative regulation of cell development
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022602 ovulation cycle process
GO:0030238 male sex determination
GO:0030336 negative regulation of cell migration
GO:0031960 response to corticosteroid
GO:0032496 response to lipopolysaccharide
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032945 negative regulation of mononuclear cell proliferation
GO:0033079 immature T cell proliferation
GO:0033083 regulation of immature T cell proliferation
GO:0033087 negative regulation of immature T cell proliferation
GO:0033574 response to testosterone
GO:0034694 response to prostaglandin
GO:0034695 response to prostaglandin E
GO:0035864 response to potassium ion
GO:0040013 negative regulation of locomotion
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042698 ovulation cycle
GO:0043434 response to peptide hormone
GO:0044706 multi-multicellular organism process
GO:0044849 estrous cycle
GO:0045137 development of primary sexual characteristics
GO:0045471 response to ethanol
GO:0046545 development of primary female sexual characteristics
GO:0046651 lymphocyte proliferation
GO:0046660 female sex differentiation
GO:0048511 rhythmic process
GO:0048545 response to steroid hormone
GO:0048608 reproductive structure development
GO:0050670 regulation of lymphocyte proliferation
GO:0050672 negative regulation of lymphocyte proliferation
GO:0050768 negative regulation of neurogenesis
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051271 negative regulation of cellular component movement
GO:0051961 negative regulation of nervous system development
GO:0061458 reproductive system development
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070664 negative regulation of leukocyte proliferation
GO:0071593 lymphocyte aggregation
GO:0097305 response to alcohol
GO:1901652 response to peptide
GO:1901654 response to ketone
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1990637 response to prolactin
GO:2000146 negative regulation of cell motility
GO:2000194 regulation of female gonad development
GO:2000241 regulation of reproductive process
GO:2000354 regulation of ovarian follicle development
GO:2001222 regulation of neuron migration
GO:2001223 negative regulation of neuron migration
Molecular Function GO:0005179 hormone activity
GO:0005183 gonadotropin hormone-releasing hormone activity
Cellular Component GO:0005791 rough endoplasmic reticulum
GO:0005798 Golgi-associated vesicle
GO:0030424 axon
GO:0030425 dendrite
GO:0030867 rough endoplasmic reticulum membrane
GO:0033267 axon part
GO:0043025 neuronal cell body
GO:0043204 perikaryon
GO:0043679 axon terminus
GO:0044297 cell body
GO:0044306 neuron projection terminus
GO:0098552 side of membrane
GO:0098554 cytoplasmic side of endoplasmic reticulum membrane
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:0098562 cytoplasmic side of membrane
GO:1990005 granular vesicle
GO:1990008 neurosecretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04912 GnRH signaling pathway
Reactome R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-375281: Hormone ligand-binding receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GNRH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GNRH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GNRH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.310.173
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.360.4
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2690.437
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.050.924
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0160.987
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.130.902
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2330.457
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1370.815
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6170.307
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7160.384
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.3520.0155
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2910.00266
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GNRH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GNRH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GNRH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GNRH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GNRH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GNRH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGNRH1
Namegonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
Aliases GRH; GNRH; LHRH; gonadotropin-releasing hormone 1 (leutinizing-releasing hormone); HH12; LNRH; GnRH-associat ......
Chromosomal Location8p21-p11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GNRH1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.