Browse GOSR2

Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus, cis-Golgi network membrane Single-pass type IV membrane protein Golgi apparatus membrane Endoplasmic reticulum membrane Note=Concentrated most in the intermediate compartment/cis-Golgi network and the cis-Golgi cisternae 1 and 2. Greatly reduced in concentration at the trans end of the Golgi apparatus.
Domain -
Function

Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.

> Gene Ontology
 
Biological Process GO:0006623 protein targeting to vacuole
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006891 intra-Golgi vesicle-mediated transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006896 Golgi to vacuole transport
GO:0006900 membrane budding
GO:0006901 vesicle coating
GO:0006903 vesicle targeting
GO:0006906 vesicle fusion
GO:0006986 response to unfolded protein
GO:0007034 vacuolar transport
GO:0016050 vesicle organization
GO:0016197 endosomal transport
GO:0016482 cytosolic transport
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034620 cellular response to unfolded protein
GO:0034976 response to endoplasmic reticulum stress
GO:0035966 response to topologically incorrect protein
GO:0035967 cellular response to topologically incorrect protein
GO:0036498 IRE1-mediated unfolded protein response
GO:0042147 retrograde transport, endosome to Golgi
GO:0044801 single-organism membrane fusion
GO:0048193 Golgi vesicle transport
GO:0048199 vesicle targeting, to, from or within Golgi
GO:0048207 vesicle targeting, rough ER to cis-Golgi
GO:0048208 COPII vesicle coating
GO:0048280 vesicle fusion with Golgi apparatus
GO:0048284 organelle fusion
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0061025 membrane fusion
GO:0072665 protein localization to vacuole
GO:0072666 establishment of protein localization to vacuole
GO:0090114 COPII-coated vesicle budding
GO:0090174 organelle membrane fusion
Molecular Function GO:0000149 SNARE binding
GO:0005484 SNAP receptor activity
Cellular Component GO:0005770 late endosome
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0010008 endosome membrane
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030133 transport vesicle
GO:0030134 ER to Golgi transport vesicle
GO:0030135 coated vesicle
GO:0030658 transport vesicle membrane
GO:0030659 cytoplasmic vesicle membrane
GO:0030662 coated vesicle membrane
GO:0031201 SNARE complex
GO:0031902 late endosome membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0044440 endosomal part
> KEGG and Reactome Pathway
 
KEGG hsa04130 SNARE interactions in vesicular transport
Reactome R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-6807878: COPI-mediated anterograde transport
R-HSA-204005: COPII (Coat Protein 2) Mediated Vesicle Transport
R-HSA-5694530: Cargo concentration in the ER
R-HSA-199977: ER to Golgi Anterograde Transport
R-HSA-381070: IRE1alpha activates chaperones
R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-6811438: Intra-Golgi traffic
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-948021: Transport to the Golgi and subsequent modification
R-HSA-381119: Unfolded Protein Response (UPR)
R-HSA-5653656: Vesicle-mediated transport
R-HSA-381038: XBP1(S) activates chaperone genes
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GOSR2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GOSR2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: 1.02; FDR: 0.041900 Sensitive to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GOSR2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0780.618
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2220.913
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0270.985
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2050.5
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0760.971
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5660.839
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0780.823
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0020.999
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1440.938
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.160.924
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2230.93
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0540.194
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GOSR2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GOSR2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GOSR2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GOSR2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GOSR2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GOSR2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GOSR2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGOSR2
Namegolgi SNAP receptor complex member 2
Aliases GS27; EPM6; 27 kDa Golgi SNARE protein; membrin
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GOSR2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.