TISIDB

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Single-pass type I membrane protein.
Domain	PF13855 Leucine rich repeat PF01462 Leucine rich repeat N-terminal domain
Function	GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

> Gene Ontology [ TOP ]
Biological Process	GO:0001933 negative regulation of protein phosphorylation GO:0006469 negative regulation of protein kinase activity GO:0007259 JAK-STAT cascade GO:0007596 blood coagulation GO:0007597 blood coagulation, intrinsic pathway GO:0007599 hemostasis GO:0030168 platelet activation GO:0030193 regulation of blood coagulation GO:0030195 negative regulation of blood coagulation GO:0032102 negative regulation of response to external stimulus GO:0033673 negative regulation of kinase activity GO:0034109 homotypic cell-cell adhesion GO:0042326 negative regulation of phosphorylation GO:0042730 fibrinolysis GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0050817 coagulation GO:0050818 regulation of coagulation GO:0050819 negative regulation of coagulation GO:0050878 regulation of body fluid levels GO:0051348 negative regulation of transferase activity GO:0061041 regulation of wound healing GO:0061045 negative regulation of wound healing GO:0070493 thrombin receptor signaling pathway GO:0070527 platelet aggregation GO:0072376 protein activation cascade GO:0072378 blood coagulation, fibrin clot formation GO:0097696 STAT cascade GO:1900046 regulation of hemostasis GO:1900047 negative regulation of hemostasis GO:1902532 negative regulation of intracellular signal transduction GO:1903034 regulation of response to wounding GO:1903035 negative regulation of response to wounding GO:1904892 regulation of STAT cascade GO:1904893 negative regulation of STAT cascade
Molecular Function	GO:0001653 peptide receptor activity GO:0004857 enzyme inhibitor activity GO:0004860 protein kinase inhibitor activity GO:0008528 G-protein coupled peptide receptor activity GO:0015057 thrombin receptor activity GO:0019207 kinase regulator activity GO:0019210 kinase inhibitor activity GO:0019887 protein kinase regulator activity
Cellular Component	GO:0009897 external side of plasma membrane GO:0031225 anchored component of membrane GO:0031233 intrinsic component of external side of plasma membrane GO:0031362 anchored component of external side of plasma membrane GO:0046658 anchored component of plasma membrane GO:0098552 side of membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04512 ECM-receptor interaction hsa04611 Platelet activation hsa04640 Hematopoietic cell lineage
Reactome	R-HSA-140877: Formation of Fibrin Clot (Clotting Cascade) R-HSA-430116: GP1b-IX-V activation signalling R-HSA-109582: Hemostasis R-HSA-140837: Intrinsic Pathway of Fibrin Clot Formation R-HSA-75892: Platelet Adhesion to exposed collagen R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GP1BA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of GP1BA in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of GP1BA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.379	0.339
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.759	0.253
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.093	0.867
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.483	0.227
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.413	0.816
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.582	0.816
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	1.375	0.00747
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.838	0.0165
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.98	0.235
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.158	0.721
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.148	0.807
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.166	0.634

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of GP1BA in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	0	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	0	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	7.7	-7.7	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	8.3	-8.3	1

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GP1BA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GP1BA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GP1BA. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GP1BA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GP1BA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GP1BA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GP1BA
Name	glycoprotein Ib (platelet), alpha polypeptide
Aliases	CD42b; GP1B; BDPLT3; BSS; CD42b-alpha; DBPLT3; GPIbA; VWDP; GP-Ib alpha; antigen CD42b-alpha; platelet membr ......
Chromosomal Location	17p13.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GP1BA collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting GP1BA.

ID	Name	Drug Type	Targets	#Targets
DB05202	Egaptivon pegol	Biotech	GP1BA, VWF	2
DB05391	liposomal prostaglandin E1	Small Molecule	GP1BA	1

Browse GP1BA