Browse GPI

Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Secreted
Domain PF00342 Phosphoglucose isomerase
Function

Besides it's role as a glycolytic enzyme, mammalian GPI can function as a tumor-secreted cytokine and an angiogenic factor (AMF) that stimulates endothelial cell motility. GPI is also a neurotrophic factor (Neuroleukin) for spinal and sensory neurons.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001701 in utero embryonic development
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0002262 myeloid cell homeostasis
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006007 glucose catabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0006090 pyruvate metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006732 coenzyme metabolic process
GO:0006733 oxidoreduction coenzyme metabolic process
GO:0006734 NADH metabolic process
GO:0006735 NADH regeneration
GO:0006757 ATP generation from ADP
GO:0006959 humoral immune response
GO:0007369 gastrulation
GO:0007498 mesoderm development
GO:0007599 hemostasis
GO:0007611 learning or memory
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009141 nucleoside triphosphate metabolic process
GO:0009144 purine nucleoside triphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009199 ribonucleoside triphosphate metabolic process
GO:0009205 purine ribonucleoside triphosphate metabolic process
GO:0009438 methylglyoxal metabolic process
GO:0009612 response to mechanical stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0014072 response to isoquinoline alkaloid
GO:0016051 carbohydrate biosynthetic process
GO:0016052 carbohydrate catabolic process
GO:0019242 methylglyoxal biosynthetic process
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0019320 hexose catabolic process
GO:0019362 pyridine nucleotide metabolic process
GO:0019674 NAD metabolic process
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0033500 carbohydrate homeostasis
GO:0033574 response to testosterone
GO:0034101 erythrocyte homeostasis
GO:0035902 response to immobilization stress
GO:0035994 response to muscle stretch
GO:0042180 cellular ketone metabolic process
GO:0042181 ketone biosynthetic process
GO:0042278 purine nucleoside metabolic process
GO:0042593 glucose homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043278 response to morphine
GO:0043279 response to alkaloid
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044708 single-organism behavior
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045861 negative regulation of proteolysis
GO:0046031 ADP metabolic process
GO:0046034 ATP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046184 aldehyde biosynthetic process
GO:0046185 aldehyde catabolic process
GO:0046364 monosaccharide biosynthetic process
GO:0046365 monosaccharide catabolic process
GO:0046496 nicotinamide nucleotide metabolic process
GO:0046686 response to cadmium ion
GO:0046939 nucleotide phosphorylation
GO:0048332 mesoderm morphogenesis
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048872 homeostasis of number of cells
GO:0050878 regulation of body fluid levels
GO:0050890 cognition
GO:0051156 glucose 6-phosphate metabolic process
GO:0051186 cofactor metabolic process
GO:0051346 negative regulation of hydrolase activity
GO:0051402 neuron apoptotic process
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0061615 glycolytic process through fructose-6-phosphate
GO:0061620 glycolytic process through glucose-6-phosphate
GO:0061621 canonical glycolysis
GO:0061718 glucose catabolic process to pyruvate
GO:0070997 neuron death
GO:0072524 pyridine-containing compound metabolic process
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901654 response to ketone
GO:1901657 glycosyl compound metabolic process
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
Molecular Function GO:0004347 glucose-6-phosphate isomerase activity
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0016853 isomerase activity
GO:0016860 intramolecular oxidoreductase activity
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
GO:0016866 intramolecular transferase activity
GO:0030246 carbohydrate binding
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0048029 monosaccharide binding
Cellular Component GO:0005929 cilium
GO:0031253 cell projection membrane
GO:0043209 myelin sheath
GO:0044441 ciliary part
GO:0060170 ciliary membrane
> KEGG and Reactome Pathway
 
KEGG hsa00010 Glycolysis / Gluconeogenesis
hsa00030 Pentose phosphate pathway
hsa00500 Starch and sucrose metabolism
hsa00520 Amino sugar and nucleotide sugar metabolism
hsa01100 Metabolic pathways
hsa01200 Carbon metabolism
Reactome R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-70263: Gluconeogenesis
R-HSA-70326: Glucose metabolism
R-HSA-70171: Glycolysis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-6798695: Neutrophil degranulation
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-3700989: Transcriptional Regulation by TP53
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GPI and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GPI in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.91; FDR: 0.00942 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 5.48; FDR: 0.001 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GPI in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0080.979
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1460.962
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0930.967
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3030.394
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0760.975
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5930.854
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1930.686
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.220.921
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1210.96
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1610.945
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3540.921
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0760.4
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GPI in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPI. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPI. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPI.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPI. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GPI expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GPI and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGPI
Nameglucose-6-phosphate isomerase
Aliases AMF; glucose phosphate isomerase; PHI; SA-36; SA36; autocrine motility factor; hexose monophosphate isomeras ......
Chromosomal Location19q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GPI collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GPI.
ID Name Drug Type Targets #Targets
DB02007alpha-D-glucose 6-phosphateSmall MoleculeAKR1B1, GPI, HK1, PYGM4
DB020766-phospho-D-gluconic acidSmall MoleculeGPI, PGD2
DB020935-Phospho-D-Arabinohydroxamic AcidSmall MoleculeGPI1
DB02548D-glucitol 6-phosphateSmall MoleculeGPI1
DB030425-Phosphoarabinonic AcidSmall MoleculeGPI1
DB03581Glucose-6-PhosphateSmall MoleculeGPI1
DB03937Erythose-4-PhosphateSmall MoleculeGPI1
DB04493Fructose-6-PhosphateSmall MoleculeFBP1, GPI, PFKFB1, PFKFB44
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141
DB11638ArtenimolSmall MoleculeACTG1, ALB, ALDH7A1, ALDOA, ANXA2, ATP5A1, ATP5L, ATP5O, CAST, CCT ......79