Browse GPLD1

Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF01839 FG-GAP repeat
PF00882 Zinc dependent phospholipase C
Function

This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001503 ossification
GO:0001525 angiogenesis
GO:0001667 ameboidal-type cell migration
GO:0001678 cellular glucose homeostasis
GO:0002040 sprouting angiogenesis
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0002062 chondrocyte differentiation
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002430 complement receptor mediated signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006505 GPI anchor metabolic process
GO:0006507 GPI anchor release
GO:0006509 membrane protein ectodomain proteolysis
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006643 membrane lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006664 glycolipid metabolic process
GO:0008286 insulin receptor signaling pathway
GO:0009268 response to pH
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009914 hormone transport
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010692 regulation of alkaline phosphatase activity
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010817 regulation of hormone levels
GO:0010866 regulation of triglyceride biosynthetic process
GO:0010867 positive regulation of triglyceride biosynthetic process
GO:0010896 regulation of triglyceride catabolic process
GO:0010897 negative regulation of triglyceride catabolic process
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010921 regulation of phosphatase activity
GO:0010922 positive regulation of phosphatase activity
GO:0010982 regulation of high-density lipoprotein particle clearance
GO:0010983 positive regulation of high-density lipoprotein particle clearance
GO:0010984 regulation of lipoprotein particle clearance
GO:0010986 positive regulation of lipoprotein particle clearance
GO:0015833 peptide transport
GO:0016042 lipid catabolic process
GO:0016311 dephosphorylation
GO:0019216 regulation of lipid metabolic process
GO:0019318 hexose metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0019835 cytolysis
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030335 positive regulation of cell migration
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0032024 positive regulation of insulin secretion
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033500 carbohydrate homeostasis
GO:0033619 membrane protein proteolysis
GO:0034014 response to triglyceride
GO:0034284 response to monosaccharide
GO:0034381 plasma lipoprotein particle clearance
GO:0034384 high-density lipoprotein particle clearance
GO:0035303 regulation of dephosphorylation
GO:0035306 positive regulation of dephosphorylation
GO:0035690 cellular response to drug
GO:0035701 hematopoietic stem cell migration
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0036314 response to sterol
GO:0036315 cellular response to sterol
GO:0040017 positive regulation of locomotion
GO:0042176 regulation of protein catabolic process
GO:0042268 regulation of cytolysis
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043434 response to peptide hormone
GO:0043534 blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0044242 cellular lipid catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045017 glycerolipid biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045833 negative regulation of lipid metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045862 positive regulation of proteolysis
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045919 positive regulation of cytolysis
GO:0046460 neutral lipid biosynthetic process
GO:0046461 neutral lipid catabolic process
GO:0046463 acylglycerol biosynthetic process
GO:0046464 acylglycerol catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046503 glycerolipid catabolic process
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0048514 blood vessel morphogenesis
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0050994 regulation of lipid catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0051043 regulation of membrane protein ectodomain proteolysis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051047 positive regulation of secretion
GO:0051216 cartilage development
GO:0051222 positive regulation of protein transport
GO:0051272 positive regulation of cellular component movement
GO:0051592 response to calcium ion
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0061448 connective tissue development
GO:0070633 transepithelial transport
GO:0070723 response to cholesterol
GO:0071214 cellular response to abiotic stimulus
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071277 cellular response to calcium ion
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071396 cellular response to lipid
GO:0071397 cellular response to cholesterol
GO:0071401 cellular response to triglyceride
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071467 cellular response to pH
GO:0090087 regulation of peptide transport
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090207 regulation of triglyceride metabolic process
GO:0090208 positive regulation of triglyceride metabolic process
GO:0090209 negative regulation of triglyceride metabolic process
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097006 regulation of plasma lipoprotein particle levels
GO:0097164 ammonium ion metabolic process
GO:0097241 hematopoietic stem cell migration to bone marrow
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:1900076 regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1903509 liposaccharide metabolic process
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
GO:2000147 positive regulation of cell motility
Molecular Function GO:0004620 phospholipase activity
GO:0004621 glycosylphosphatidylinositol phospholipase D activity
GO:0004630 phospholipase D activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016247 channel regulator activity
GO:0016298 lipase activity
GO:0017080 sodium channel regulator activity
GO:0042578 phosphoric ester hydrolase activity
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005765 lysosomal membrane
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-163125: Post-translational modification
R-HSA-597592: Post-translational protein modification
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GPLD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GPLD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GPLD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.5080.142
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0860.886
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.8180.103
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5040.286
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1290.937
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.9890.576
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.5080.271
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8270.298
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2120.797
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4610.532
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3820.686
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6560.000689
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GPLD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GPLD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GPLD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GPLD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GPLD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GPLD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GPLD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGPLD1
Nameglycosylphosphatidylinositol specific phospholipase D1
Aliases GPIPLD; GPIPLDM; PIGPLD; PIGPLD1; GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipas ......
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GPLD1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.