TISIDB

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm
Domain	PF14497 Glutathione S-transferase PF13417 Glutathione S-transferase
Function	Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid.

> Gene Ontology [ TOP ]
Biological Process	GO:0006520 cellular amino acid metabolic process GO:0006558 L-phenylalanine metabolic process GO:0006559 L-phenylalanine catabolic process GO:0006570 tyrosine metabolic process GO:0006572 tyrosine catabolic process GO:0006575 cellular modified amino acid metabolic process GO:0006749 glutathione metabolic process GO:0006790 sulfur compound metabolic process GO:0009063 cellular amino acid catabolic process GO:0009072 aromatic amino acid family metabolic process GO:0009074 aromatic amino acid family catabolic process GO:0009636 response to toxic substance GO:0016054 organic acid catabolic process GO:0019439 aromatic compound catabolic process GO:0044272 sulfur compound biosynthetic process GO:0044282 small molecule catabolic process GO:0046395 carboxylic acid catabolic process GO:0098754 detoxification GO:0098869 cellular oxidant detoxification GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1901685 glutathione derivative metabolic process GO:1901687 glutathione derivative biosynthetic process GO:1990748 cellular detoxification
Molecular Function	GO:0004364 glutathione transferase activity GO:0004601 peroxidase activity GO:0004602 glutathione peroxidase activity GO:0016034 maleylacetoacetate isomerase activity GO:0016209 antioxidant activity GO:0016684 oxidoreductase activity, acting on peroxide as acceptor GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016853 isomerase activity GO:0016859 cis-trans isomerase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00350 Tyrosine metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-211859: Biological oxidations R-HSA-156590: Glutathione conjugation R-HSA-6788656: Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-156580: Phase II conjugation R-HSA-71182: Phenylalanine and tyrosine catabolism

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between GSTZ1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of GSTZ1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of GSTZ1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.787	0.00807
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.679	0.714
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.867	0.52
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.315	0.36
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.494	0.712
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.094	0.959
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.095	0.771
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.077	0.942
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.239	0.857
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.629	0.671
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.435	0.842
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.006	0.954

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of GSTZ1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GSTZ1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GSTZ1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GSTZ1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GSTZ1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of GSTZ1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between GSTZ1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	GSTZ1
Name	glutathione S-transferase zeta 1
Aliases	GSTZ1-1; MAAI; MAI; maleylacetoacetate isomerase; glutathione transferase zeta 1; maleylacetone isomerase
Chromosomal Location	14q24.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting GSTZ1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting GSTZ1.

ID	Name	Drug Type	Targets	#Targets
DB00143	Glutathione	Small Molecule	AKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......	41
DB04447	1,4-Dithiothreitol	Small Molecule	ALDH1A1, AXIN1, CAMK2A, GSTZ1, HMGCR, LGALS1, MSRA, PPIB, TPI1, TR ......	10
DB08809	Dichloroacetic Acid	Small Molecule	GSTZ1, PDK1	2

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