Browse GTF2H5

Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF06331 Transcription factor TFIIH complex subunit Tfb5
Function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.

> Gene Ontology
 
Biological Process GO:0000717 nucleotide-excision repair, DNA duplex unwinding
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006293 nucleotide-excision repair, preincision complex stabilization
GO:0006294 nucleotide-excision repair, preincision complex assembly
GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion
GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006352 DNA-templated transcription, initiation
GO:0006353 DNA-templated transcription, termination
GO:0006354 DNA-templated transcription, elongation
GO:0006360 transcription from RNA polymerase I promoter
GO:0006361 transcription initiation from RNA polymerase I promoter
GO:0006362 transcription elongation from RNA polymerase I promoter
GO:0006363 termination of RNA polymerase I transcription
GO:0006364 rRNA processing
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0006397 mRNA processing
GO:0009314 response to radiation
GO:0009452 7-methylguanosine RNA capping
GO:0010212 response to ionizing radiation
GO:0010332 response to gamma radiation
GO:0016072 rRNA metabolic process
GO:0022613 ribonucleoprotein complex biogenesis
GO:0031334 positive regulation of protein complex assembly
GO:0032392 DNA geometric change
GO:0032508 DNA duplex unwinding
GO:0033683 nucleotide-excision repair, DNA incision
GO:0034470 ncRNA processing
GO:0036260 RNA capping
GO:0042254 ribosome biogenesis
GO:0043254 regulation of protein complex assembly
GO:0044089 positive regulation of cellular component biogenesis
GO:0065004 protein-DNA complex assembly
GO:0070911 global genome nucleotide-excision repair
GO:0071103 DNA conformation change
GO:0071214 cellular response to abiotic stimulus
GO:0071478 cellular response to radiation
GO:0071479 cellular response to ionizing radiation
GO:0071480 cellular response to gamma radiation
GO:0071824 protein-DNA complex subunit organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Molecular Function GO:0000182 rDNA binding
Cellular Component GO:0000439 core TFIIH complex
> KEGG and Reactome Pathway
 
KEGG hsa03022 Basal transcription factors
hsa03420 Nucleotide excision repair
Reactome R-HSA-73894: DNA Repair
R-HSA-1643685: Disease
R-HSA-5696400: Dual Incision in GG-NER
R-HSA-6782135: Dual incision in TC-NER
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-167152: Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200: Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-5696395: Formation of Incision Complex in GG-NER
R-HSA-112382: Formation of RNA Pol II elongation complex
R-HSA-6781823: Formation of TC-NER Pre-Incision Complex
R-HSA-113418: Formation of the Early Elongation Complex
R-HSA-167158: Formation of the HIV-1 Early Elongation Complex
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-5696399: Global Genome Nucleotide Excision Repair (GG-NER)
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-167169: HIV Transcription Elongation
R-HSA-167161: HIV Transcription Initiation
R-HSA-5663205: Infectious disease
R-HSA-162599: Late Phase of HIV Life Cycle
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-77075: RNA Pol II CTD phosphorylation and interaction with CE
R-HSA-167160: RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
R-HSA-73777: RNA Polymerase I Chain Elongation
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73772: RNA Polymerase I Promoter Escape
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-73863: RNA Polymerase I Transcription Termination
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-167162: RNA Polymerase II HIV Promoter Escape
R-HSA-674695: RNA Polymerase II Pre-transcription Events
R-HSA-73776: RNA Polymerase II Promoter Escape
R-HSA-73857: RNA Polymerase II Transcription
R-HSA-75955: RNA Polymerase II Transcription Elongation
R-HSA-75953: RNA Polymerase II Transcription Initiation
R-HSA-76042: RNA Polymerase II Transcription Initiation And Promoter Clearance
R-HSA-73779: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-6796648: TP53 Regulates Transcription of DNA Repair Genes
R-HSA-167246: Tat-mediated elongation of the HIV-1 transcript
R-HSA-167172: Transcription of the HIV genome
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-72086: mRNA Capping
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GTF2H5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GTF2H5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.63 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GTF2H5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.50.0195
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7020.555
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3520.687
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1650.611
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0410.967
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3180.784
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.240.455
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3810.779
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1020.947
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0930.896
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.1060.921
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0770.28
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GTF2H5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GTF2H5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GTF2H5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GTF2H5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GTF2H5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GTF2H5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGTF2H5
Namegeneral transcription factor IIH, polypeptide 5
Aliases FLJ30544; bA120J8.2; TTD-A; TFB5; TTDA; DNA repair syndrome trichothiodystrophy group A; C6orf175; chromosom ......
Chromosomal Location6q25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GTF2H5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.