Summary | |
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Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF01926 50S ribosome-binding GTPase PF12631 MnmE helical domain PF10396 GTP-binding protein TrmE N-terminus |
Function |
GTPase involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. |
Biological Process |
GO:0001510 RNA methylation GO:0002097 tRNA wobble base modification GO:0002098 tRNA wobble uridine modification GO:0006399 tRNA metabolic process GO:0006400 tRNA modification GO:0008033 tRNA processing GO:0009451 RNA modification GO:0030488 tRNA methylation GO:0032259 methylation GO:0034470 ncRNA processing GO:0043414 macromolecule methylation |
Molecular Function |
GO:0003924 GTPase activity GO:0005525 GTP binding GO:0019001 guanyl nucleotide binding GO:0032561 guanyl ribonucleotide binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6787450: tRNA modification in the mitochondrion R-HSA-72306: tRNA processing |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between GTPBP3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of GTPBP3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of GTPBP3 in various data sets.
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Points in the above scatter plot represent the mutation difference of GTPBP3 in various data sets.
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Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GTPBP3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GTPBP3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GTPBP3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GTPBP3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of GTPBP3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between GTPBP3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | GTPBP3 |
Name | GTP binding protein 3 (mitochondrial) |
Aliases | THDF1; GTPBG3; MTGP1; FLJ14700; COXPD23; mitochondrial GTP-binding protein 1; tRNA modification GTPase GTPBP ...... |
Chromosomal Location | 19p13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting GTPBP3 collected from DrugBank database. |
There is no record. |