Browse H1F0

Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Chromosome Note=The RNA edited version has been localized to nuclear speckles. During mitosis, it appears in the vicinity of condensed chromosomes.
Domain PF00538 linker histone H1 and H5 family
Function

Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. The H1F0 histones are found in cells that are in terminal stages of differentiation or that have low rates of cell division.

> Gene Ontology
 
Biological Process GO:0000737 DNA catabolic process, endonucleolytic
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0019439 aromatic compound catabolic process
GO:0030262 apoptotic nuclear changes
GO:0031497 chromatin assembly
GO:0034655 nucleobase-containing compound catabolic process
GO:0034728 nucleosome organization
GO:0044270 cellular nitrogen compound catabolic process
GO:0046700 heterocycle catabolic process
GO:0065004 protein-DNA complex assembly
GO:0071103 DNA conformation change
GO:0071824 protein-DNA complex subunit organization
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0097194 execution phase of apoptosis
GO:1901361 organic cyclic compound catabolic process
Molecular Function GO:0003682 chromatin binding
GO:0031490 chromatin DNA binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000790 nuclear chromatin
GO:0000791 euchromatin
GO:0005719 nuclear euchromatin
GO:0015629 actin cytoskeleton
GO:0032993 protein-DNA complex
GO:0044454 nuclear chromosome part
GO:0044815 DNA packaging complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-211227: Activation of DNA fragmentation factor
R-HSA-109581: Apoptosis
R-HSA-140342: Apoptosis induced DNA fragmentation
R-HSA-75153: Apoptotic execution phase
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence
R-HSA-2559584: Formation of Senescence-Associated Heterochromatin Foci (SAHF)
R-HSA-5357801: Programmed Cell Death
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between H1F0 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of H1F0 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of H1F0 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.5130.0012
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.1340.51
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.0440.626
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4240.358
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3550.865
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5210.859
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.3420.533
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.6070.772
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0740.975
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6870.734
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1770.693
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1380.268
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of H1F0. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of H1F0. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by H1F0.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of H1F0. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of H1F0 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between H1F0 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolH1F0
NameH1 histone family, member 0
Aliases H10; H1.0, H1(0), H1-0; H1FV; histone H1'; histone H1(0); Histone H1.0
Chromosomal Location22q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting H1F0 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.