TISIDB

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Chromosome.
Domain	PF00125 Core histone H2A/H2B/H3/H4 PF16211 C-terminus of histone H2A
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.

> Gene Ontology [ TOP ]
Biological Process	GO:0006342 chromatin silencing GO:0016458 gene silencing GO:0032355 response to estradiol GO:0040029 regulation of gene expression, epigenetic GO:0045814 negative regulation of gene expression, epigenetic GO:0071392 cellular response to estradiol stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound
Molecular Function	GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000987 core promoter proximal region sequence-specific DNA binding GO:0001046 core promoter sequence-specific DNA binding GO:0001047 core promoter binding GO:0001158 enhancer sequence-specific DNA binding GO:0001159 core promoter proximal region DNA binding GO:0003682 chromatin binding GO:0031490 chromatin DNA binding GO:0031491 nucleosome binding GO:0031492 nucleosomal DNA binding GO:0035326 enhancer binding GO:0043566 structure-specific DNA binding GO:0046982 protein heterodimerization activity
Cellular Component	GO:0000785 chromatin GO:0000786 nucleosome GO:0000790 nuclear chromatin GO:0000791 euchromatin GO:0000792 heterochromatin GO:0005719 nuclear euchromatin GO:0005720 nuclear heterochromatin GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0044815 DNA packaging complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-977225: Amyloid fiber formation R-HSA-5250924: B-WICH complex positively regulates rRNA expression R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-3247509: Chromatin modifying enzymes R-HSA-4839726: Chromatin organization R-HSA-73886: Chromosome Maintenance R-HSA-2299718: Condensation of Prophase Chromosomes R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence R-HSA-5334118: DNA methylation R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-1266738: Developmental Biology R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression R-HSA-212165: Epigenetic regulation of gene expression R-HSA-201722: Formation of the beta-catenin R-HSA-74160: Gene Expression R-HSA-211000: Gene Silencing by RNA R-HSA-68886: M Phase R-HSA-1500620: Meiosis R-HSA-912446: Meiotic recombination R-HSA-1221632: Meiotic synapsis R-HSA-392499: Metabolism of proteins R-HSA-68875: Mitotic Prophase R-HSA-5250941: Negative epigenetic regulation of rRNA expression R-HSA-427413: NoRC negatively regulates rRNA expression R-HSA-774815: Nucleosome assembly R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-212300: PRC2 methylates histones and DNA R-HSA-171306: Packaging Of Telomere Ends R-HSA-5250913: Positive epigenetic regulation of rRNA expression R-HSA-195258: RHO GTPase Effectors R-HSA-5625740: RHO GTPases activate PKNs R-HSA-3214858: RMTs methylate histone arginines R-HSA-73777: RNA Polymerase I Chain Elongation R-HSA-73854: RNA Polymerase I Promoter Clearance R-HSA-73728: RNA Polymerase I Promoter Opening R-HSA-73864: RNA Polymerase I Transcription R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-427359: SIRT1 negatively regulates rRNA Expression R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP) R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-195721: Signaling by Wnt R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-157579: Telomere Maintenance R-HSA-5578749: Transcriptional regulation by small RNAs

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-5625886: Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-HSA-5619507: Activation of HOX genes during differentiation
R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis
R-HSA-977225: Amyloid fiber formation
R-HSA-5250924: B-WICH complex positively regulates rRNA expression
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-73886: Chromosome Maintenance
R-HSA-2299718: Condensation of Prophase Chromosomes
R-HSA-2559586: DNA Damage/Telomere Stress Induced Senescence
R-HSA-5334118: DNA methylation
R-HSA-606279: Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-1266738: Developmental Biology
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-201722: Formation of the beta-catenin
R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-68886: M Phase
R-HSA-1500620: Meiosis
R-HSA-912446: Meiotic recombination
R-HSA-1221632: Meiotic synapsis
R-HSA-392499: Metabolism of proteins
R-HSA-68875: Mitotic Prophase
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-774815: Nucleosome assembly
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-212300: PRC2 methylates histones and DNA
R-HSA-171306: Packaging Of Telomere Ends
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-195258: RHO GTPase Effectors
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-3214858: RMTs methylate histone arginines
R-HSA-73777: RNA Polymerase I Chain Elongation
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73728: RNA Polymerase I Promoter Opening
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-427359: SIRT1 negatively regulates rRNA Expression
R-HSA-2559582: Senescence-Associated Secretory Phenotype (SASP)
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-157579: Telomere Maintenance
R-HSA-5578749: Transcriptional regulation by small RNAs

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between H2AFZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of H2AFZ in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.55	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of H2AFZ in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.098	0.757
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.207	0.959
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.021	0.994
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.012	0.97
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.129	0.937
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.187	0.93
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.221	0.663
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.529	0.817
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.096	0.97
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.031	0.989
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.079	0.983
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.309	0.000408

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of H2AFZ in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	16.7	-16.7	0.429
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of H2AFZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of H2AFZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by H2AFZ. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of H2AFZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of H2AFZ expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between H2AFZ and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	H2AFZ
Name	H2A histone family, member Z
Aliases	H2A.Z; H2AZ; H2A.Z-1; H2A/z; H2AZ histone; Histone H2A.Z
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting H2AFZ collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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