Browse HAGH

Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Mitochondrion matrix ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
Domain PF16123 Hydroxyacylglutathione hydrolase C-terminus
PF00753 Metallo-beta-lactamase superfamily
Function

Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.

> Gene Ontology
 
Biological Process GO:0006081 cellular aldehyde metabolic process
GO:0006089 lactate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006575 cellular modified amino acid metabolic process
GO:0006749 glutathione metabolic process
GO:0006750 glutathione biosynthetic process
GO:0006790 sulfur compound metabolic process
GO:0009438 methylglyoxal metabolic process
GO:0019184 nonribosomal peptide biosynthetic process
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione
GO:0042180 cellular ketone metabolic process
GO:0042182 ketone catabolic process
GO:0042398 cellular modified amino acid biosynthetic process
GO:0044272 sulfur compound biosynthetic process
GO:0044282 small molecule catabolic process
GO:0046185 aldehyde catabolic process
GO:0051596 methylglyoxal catabolic process
GO:0061727 methylglyoxal catabolic process to lactate
Molecular Function GO:0004416 hydroxyacylglutathione hydrolase activity
GO:0016790 thiolester hydrolase activity
Cellular Component GO:0005759 mitochondrial matrix
> KEGG and Reactome Pathway
 
KEGG hsa00620 Pyruvate metabolism
Reactome R-HSA-1430728: Metabolism
R-HSA-70268: Pyruvate metabolism
R-HSA-71406: Pyruvate metabolism and Citric Acid (TCA) cycle
R-HSA-1428517: The citric acid (TCA) cycle and respiratory electron transport
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HAGH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HAGH in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -1.83; FDR: 0.04630 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HAGH in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0710.803
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.230.92
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0430.979
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2250.485
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1640.919
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3040.884
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0310.925
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0490.97
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.060.968
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0840.962
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0980.971
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0030.961
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HAGH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HAGH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HAGH.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HAGH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HAGH expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HAGH and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHAGH
Namehydroxyacylglutathione hydrolase
Aliases GLO2; GLXII; HAGH1; hydroxyacyl glutathione hydrolase; GLX2; GLXII1; glx II; glyoxalase II; hydroxyacylgluta ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HAGH collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HAGH.
ID Name Drug Type Targets #Targets
DB00143GlutathioneSmall MoleculeAKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......41
DB03889S-(N-Hydroxy-N-Bromophenylcarbamoyl)GlutathioneSmall MoleculeHAGH1