Browse HDAC1

Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00850 Histone deacetylase domain
Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B. Deacetylates NR1D2 and abrogates the effect of KAT5-mediated relieving of NR1D2 transcription repression activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Involved in CIART-mediated transcriptional repression of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1 heterodimer. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex or CRY1 through histone deacetylation.

> Gene Ontology
 
Biological Process GO:0001654 eye development
GO:0001819 positive regulation of cytokine production
GO:0001942 hair follicle development
GO:0001975 response to amphetamine
GO:0002237 response to molecule of bacterial origin
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002792 negative regulation of peptide secretion
GO:0006338 chromatin remodeling
GO:0006342 chromatin silencing
GO:0006346 methylation-dependent chromatin silencing
GO:0006473 protein acetylation
GO:0006476 protein deacetylation
GO:0006979 response to oxidative stress
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007423 sensory organ development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0007623 circadian rhythm
GO:0008544 epidermis development
GO:0009306 protein secretion
GO:0009755 hormone-mediated signaling pathway
GO:0009913 epidermal cell differentiation
GO:0009914 hormone transport
GO:0010001 glial cell differentiation
GO:0010720 positive regulation of cell development
GO:0010817 regulation of hormone levels
GO:0010869 regulation of receptor biosynthetic process
GO:0010870 positive regulation of receptor biosynthetic process
GO:0014013 regulation of gliogenesis
GO:0014015 positive regulation of gliogenesis
GO:0014074 response to purine-containing compound
GO:0014075 response to amine
GO:0015833 peptide transport
GO:0016055 Wnt signaling pathway
GO:0016458 gene silencing
GO:0016570 histone modification
GO:0016575 histone deacetylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018205 peptidyl-lysine modification
GO:0018212 peptidyl-tyrosine modification
GO:0018394 peptidyl-lysine acetylation
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030326 embryonic limb morphogenesis
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030521 androgen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0031000 response to caffeine
GO:0032496 response to lipopolysaccharide
GO:0032602 chemokine production
GO:0032612 interleukin-1 production
GO:0032640 tumor necrosis factor production
GO:0032642 regulation of chemokine production
GO:0032652 regulation of interleukin-1 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032722 positive regulation of chemokine production
GO:0032732 positive regulation of interleukin-1 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0032800 receptor biosynthetic process
GO:0032897 negative regulation of viral transcription
GO:0032922 circadian regulation of gene expression
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0034599 cellular response to oxidative stress
GO:0034612 response to tumor necrosis factor
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035601 protein deacylation
GO:0035821 modification of morphology or physiology of other organism
GO:0036296 response to increased oxygen levels
GO:0040029 regulation of gene expression, epigenetic
GO:0042063 gliogenesis
GO:0042303 molting cycle
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042633 hair cycle
GO:0042733 embryonic digit morphogenesis
GO:0042886 amide transport
GO:0043010 camera-type eye development
GO:0043044 ATP-dependent chromatin remodeling
GO:0043112 receptor metabolic process
GO:0043279 response to alkaloid
GO:0043401 steroid hormone mediated signaling pathway
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043543 protein acylation
GO:0043586 tongue development
GO:0043587 tongue morphogenesis
GO:0043588 skin development
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0043921 modulation by host of viral transcription
GO:0043922 negative regulation by host of viral transcription
GO:0044033 multi-organism metabolic process
GO:0045685 regulation of glial cell differentiation
GO:0045687 positive regulation of glial cell differentiation
GO:0045814 negative regulation of gene expression, epigenetic
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046676 negative regulation of insulin secretion
GO:0046782 regulation of viral transcription
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0048511 rhythmic process
GO:0048525 negative regulation of viral process
GO:0048545 response to steroid hormone
GO:0048709 oligodendrocyte differentiation
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0048736 appendage development
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050792 regulation of viral process
GO:0050796 regulation of insulin secretion
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051224 negative regulation of protein transport
GO:0051402 neuron apoptotic process
GO:0051702 interaction with symbiont
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0051962 positive regulation of nervous system development
GO:0052312 modulation of transcription in other organism involved in symbiotic interaction
GO:0052472 modulation by host of symbiont transcription
GO:0055093 response to hyperoxia
GO:0060070 canonical Wnt signaling pathway
GO:0060173 limb development
GO:0060765 regulation of androgen receptor signaling pathway
GO:0060766 negative regulation of androgen receptor signaling pathway
GO:0060788 ectodermal placode formation
GO:0060789 hair follicle placode formation
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061029 eyelid development in camera-type eye
GO:0061196 fungiform papilla development
GO:0061197 fungiform papilla morphogenesis
GO:0061198 fungiform papilla formation
GO:0070482 response to oxygen levels
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0070997 neuron death
GO:0071356 cellular response to tumor necrosis factor
GO:0071383 cellular response to steroid hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071696 ectodermal placode development
GO:0071697 ectodermal placode morphogenesis
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0072331 signal transduction by p53 class mediator
GO:0072567 chemokine (C-X-C motif) ligand 2 production
GO:0090087 regulation of peptide transport
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090276 regulation of peptide hormone secretion
GO:0090278 negative regulation of peptide hormone secretion
GO:0090596 sensory organ morphogenesis
GO:0097050 type B pancreatic cell apoptotic process
GO:0097696 STAT cascade
GO:0098732 macromolecule deacylation
GO:0098773 skin epidermis development
GO:0198738 cell-cell signaling by wnt
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901983 regulation of protein acetylation
GO:1901984 negative regulation of protein acetylation
GO:1903531 negative regulation of secretion by cell
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904037 positive regulation of epithelial cell apoptotic process
GO:1904837 beta-catenin-TCF complex assembly
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1904950 negative regulation of establishment of protein localization
GO:2000341 regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production
GO:2000674 regulation of type B pancreatic cell apoptotic process
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000757 negative regulation of peptidyl-lysine acetylation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001106 RNA polymerase II transcription corepressor activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0003682 chromatin binding
GO:0003714 transcription corepressor activity
GO:0004407 histone deacetylase activity
GO:0008134 transcription factor binding
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019213 deacetylase activity
GO:0031078 histone deacetylase activity (H3-K14 specific)
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0033558 protein deacetylase activity
GO:0033613 activating transcription factor binding
GO:0034979 NAD-dependent protein deacetylase activity
GO:0035326 enhancer binding
GO:0042826 histone deacetylase binding
GO:0043566 structure-specific DNA binding
GO:0047485 protein N-terminus binding
GO:0051059 NF-kappaB binding
GO:0070491 repressing transcription factor binding
Cellular Component GO:0000118 histone deacetylase complex
GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0016580 Sin3 complex
GO:0016581 NuRD complex
GO:0017053 transcriptional repressor complex
GO:0044454 nuclear chromosome part
GO:0070603 SWI/SNF superfamily-type complex
GO:0070822 Sin3-type complex
GO:0090545 CHD-type complex
GO:0090568 nuclear transcriptional repressor complex
> KEGG and Reactome Pathway
 
KEGG hsa04110 Cell cycle
hsa04330 Notch signaling pathway
hsa04919 Thyroid hormone signaling pathway
Reactome R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-195253: Degradation of beta-catenin by the destruction complex
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2173795: Downregulation of SMAD2/3
R-HSA-427389: ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
R-HSA-212165: Epigenetic regulation of gene expression
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-201722: Formation of the beta-catenin
R-HSA-1538133: G0 and Early G1
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-3214815: HDACs deacetylate histones
R-HSA-109582: Hemostasis
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-5250941: Negative epigenetic regulation of rRNA expression
R-HSA-427413: NoRC negatively regulates rRNA expression
R-HSA-5250913: Positive epigenetic regulation of rRNA expression
R-HSA-73854: RNA Polymerase I Promoter Clearance
R-HSA-73864: RNA Polymerase I Transcription
R-HSA-73762: RNA Polymerase I Transcription Initiation
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-4641265: Repression of WNT target genes
R-HSA-2173796: SMAD2/SMAD3
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer
R-HSA-170834: Signaling by TGF-beta Receptor Complex
R-HSA-195721: Signaling by Wnt
R-HSA-166520: Signalling by NGF
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-2173793: Transcriptional activity of SMAD2/SMAD3
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-193670: p75NTR negatively regulates cell cycle via SC1
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HDAC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HDAC1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29670692prostate carcinomaPromote immunityIn order to take advantage of both immunotherapeutic and epigenetic antitumor agents, the first generation of dual indoleamine 2,3-dioxygenase 1 (IDO1) and histone deacetylase (HDAC) inhibitors were designed.
29670692prostate carcinomaPromote immunityThe highly active dual inhibitor 10 showed excellent and balanced activity against both IDO1 (IC50 = 69.0 nM) and HDAC1 (IC50 = 66.5 nM), whose dual targeting mechanisms were validated in cancer cells.
28716899Squamous Cell CarcinomaInhibit immunity; Resistant to immunotherapyHDAC1 Upregulation by NANOG Promotes Multidrug Resistance and a Stem-like Phenotype in Immune Edited Tumor Cells. Importantly, HDAC inhibition synergized with Ag-specific adoptive T-cell therapy to control immune refractory cancers.
23312906Glioma; MesotheliomaPromote immunityIn two non epithelial cancers (glioma and mesothelioma), we found that the epigenetic regulation of the NY-ESO1 gene requires the sequential recruitment of the HDAC1-mSin3a-NCOR, Dnmt3b-HDAC1-Egr1 and Dnmt1-PCNA-UHRF1-G9a complexes.The NY-ESO1 gene is a cancer/testis antigen considered to be suitable target for the immunotherapy of human malignancies.
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HDAC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HDAC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0450.81
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1490.958
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.180.926
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2450.394
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2270.906
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2710.913
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1360.746
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1690.927
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1220.952
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3550.835
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7990.759
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1190.0881
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HDAC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HDAC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HDAC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HDAC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HDAC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HDAC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHDAC1
Namehistone deacetylase 1
Aliases GON-10; RPD3L1; reduced potassium dependency, yeast homolog-like 1
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HDAC1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HDAC1.
ID Name Drug Type Targets #Targets
DB01169Arsenic trioxideSmall MoleculeAKT1, CCND1, CDKN1A, HDAC1, IKBKB, JUN, MAPK1, MAPK3, PML, TXNRD110
DB01593ZincSmall MoleculeA1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......119
DB02546VorinostatSmall MoleculeHDAC1, HDAC2, HDAC3, HDAC6, HDAC85
DB05015BelinostatSmall MoleculeHDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, H ......11
DB05223PracinostatSmall MoleculeHDAC1, HDAC2, HDAC3, HDAC64
DB06176RomidepsinSmall MoleculeABCC1, HDAC1, HDAC2, HDAC4, HDAC65
DB06603PanobinostatSmall MoleculeHDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, H ......11
DB08868FingolimodSmall MoleculeHDAC1, S1PR52
DB11830MocetinostatSmall MoleculeHDAC1, HDAC2, HDAC33
DB12565AbexinostatSmall MoleculeHDAC11