TISIDB

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Domain	PF12203 Glutamine rich N terminal domain of histone deacetylase 4 PF00850 Histone deacetylase domain
Function	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Deacetylates HSPA1A and HSPA1B at 'Lys-77' leading to their preferential binding to co-chaperone STUB1 (PubMed:27708256).

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0002076 osteoblast development GO:0002521 leukocyte differentiation GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003015 heart process GO:0003299 muscle hypertrophy in response to stress GO:0003300 cardiac muscle hypertrophy GO:0006090 pyruvate metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006096 glycolytic process GO:0006109 regulation of carbohydrate metabolic process GO:0006110 regulation of glycolytic process GO:0006140 regulation of nucleotide metabolic process GO:0006165 nucleoside diphosphate phosphorylation GO:0006338 chromatin remodeling GO:0006476 protein deacetylation GO:0006732 coenzyme metabolic process GO:0006733 oxidoreduction coenzyme metabolic process GO:0006757 ATP generation from ADP GO:0006936 muscle contraction GO:0006937 regulation of muscle contraction GO:0006941 striated muscle contraction GO:0006942 regulation of striated muscle contraction GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009116 nucleoside metabolic process GO:0009118 regulation of nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009123 nucleoside monophosphate metabolic process GO:0009126 purine nucleoside monophosphate metabolic process GO:0009132 nucleoside diphosphate metabolic process GO:0009135 purine nucleoside diphosphate metabolic process GO:0009141 nucleoside triphosphate metabolic process GO:0009144 purine nucleoside triphosphate metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009161 ribonucleoside monophosphate metabolic process GO:0009167 purine ribonucleoside monophosphate metabolic process GO:0009179 purine ribonucleoside diphosphate metabolic process GO:0009185 ribonucleoside diphosphate metabolic process GO:0009199 ribonucleoside triphosphate metabolic process GO:0009205 purine ribonucleoside triphosphate metabolic process GO:0009612 response to mechanical stimulus GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0010591 regulation of lamellipodium assembly GO:0010592 positive regulation of lamellipodium assembly GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010677 negative regulation of cellular carbohydrate metabolic process GO:0010830 regulation of myotube differentiation GO:0010832 negative regulation of myotube differentiation GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling GO:0014706 striated muscle tissue development GO:0014812 muscle cell migration GO:0014854 response to inactivity GO:0014870 response to muscle inactivity GO:0014874 response to stimulus involved in regulation of muscle adaptation GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation GO:0014887 cardiac muscle adaptation GO:0014888 striated muscle adaptation GO:0014894 response to denervation involved in regulation of muscle adaptation GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014898 cardiac muscle hypertrophy in response to stress GO:0014902 myotube differentiation GO:0014904 myotube cell development GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0016052 carbohydrate catabolic process GO:0016202 regulation of striated muscle tissue development GO:0016570 histone modification GO:0016575 histone deacetylation GO:0016925 protein sumoylation GO:0018205 peptidyl-lysine modification GO:0019362 pyridine nucleotide metabolic process GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0030031 cell projection assembly GO:0030032 lamellipodium assembly GO:0030098 lymphocyte differentiation GO:0030183 B cell differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030335 positive regulation of cell migration GO:0031346 positive regulation of cell projection organization GO:0033002 muscle cell proliferation GO:0033233 regulation of protein sumoylation GO:0033235 positive regulation of protein sumoylation GO:0034612 response to tumor necrosis factor GO:0034983 peptidyl-lysine deacetylation GO:0035601 protein deacylation GO:0040017 positive regulation of locomotion GO:0040029 regulation of gene expression, epigenetic GO:0042113 B cell activation GO:0042278 purine nucleoside metabolic process GO:0042326 negative regulation of phosphorylation GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0043393 regulation of protein binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0043467 regulation of generation of precursor metabolites and energy GO:0043470 regulation of carbohydrate catabolic process GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0044057 regulation of system process GO:0044089 positive regulation of cellular component biogenesis GO:0044262 cellular carbohydrate metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0044724 single-organism carbohydrate catabolic process GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045820 negative regulation of glycolytic process GO:0045912 negative regulation of carbohydrate metabolic process GO:0045978 negative regulation of nucleoside metabolic process GO:0045980 negative regulation of nucleotide metabolic process GO:0046031 ADP metabolic process GO:0046034 ATP metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0046496 nicotinamide nucleotide metabolic process GO:0046939 nucleotide phosphorylation GO:0048634 regulation of muscle organ development GO:0048641 regulation of skeletal muscle tissue development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048741 skeletal muscle fiber development GO:0048742 regulation of skeletal muscle fiber development GO:0048747 muscle fiber development GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051146 striated muscle cell differentiation GO:0051147 regulation of muscle cell differentiation GO:0051148 negative regulation of muscle cell differentiation GO:0051153 regulation of striated muscle cell differentiation GO:0051154 negative regulation of striated muscle cell differentiation GO:0051186 cofactor metabolic process GO:0051193 regulation of cofactor metabolic process GO:0051195 negative regulation of cofactor metabolic process GO:0051196 regulation of coenzyme metabolic process GO:0051198 negative regulation of coenzyme metabolic process GO:0051272 positive regulation of cellular component movement GO:0051402 neuron apoptotic process GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055117 regulation of cardiac muscle contraction GO:0060047 heart contraction GO:0060048 cardiac muscle contraction GO:0060491 regulation of cell projection assembly GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0070555 response to interleukin-1 GO:0070932 histone H3 deacetylation GO:0070933 histone H4 deacetylation GO:0070997 neuron death GO:0071107 response to parathyroid hormone GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071356 cellular response to tumor necrosis factor GO:0071374 cellular response to parathyroid hormone stimulus GO:0071496 cellular response to external stimulus GO:0072524 pyridine-containing compound metabolic process GO:0072593 reactive oxygen species metabolic process GO:0090257 regulation of muscle system process GO:0097581 lamellipodium organization GO:0098732 macromolecule deacylation GO:1900542 regulation of purine nucleotide metabolic process GO:1900543 negative regulation of purine nucleotide metabolic process GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901657 glycosyl compound metabolic process GO:1901861 regulation of muscle tissue development GO:1902743 regulation of lamellipodium organization GO:1902745 positive regulation of lamellipodium organization GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903322 positive regulation of protein modification by small protein conjugation or removal GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903578 regulation of ATP metabolic process GO:1903579 negative regulation of ATP metabolic process GO:2000147 positive regulation of cell motility GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process
Molecular Function	GO:0001025 RNA polymerase III transcription factor binding GO:0001047 core promoter binding GO:0003682 chromatin binding GO:0003714 transcription corepressor activity GO:0004407 histone deacetylase activity GO:0008134 transcription factor binding GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0017136 NAD-dependent histone deacetylase activity GO:0019213 deacetylase activity GO:0030955 potassium ion binding GO:0031078 histone deacetylase activity (H3-K14 specific) GO:0031420 alkali metal ion binding GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) GO:0033558 protein deacetylase activity GO:0033613 activating transcription factor binding GO:0034979 NAD-dependent protein deacetylase activity GO:0042826 histone deacetylase binding GO:0070491 repressing transcription factor binding
Cellular Component	GO:0000118 histone deacetylase complex GO:0015629 actin cytoskeleton GO:0017053 transcriptional repressor complex GO:0030016 myofibril GO:0030017 sarcomere GO:0030018 Z disc GO:0031594 neuromuscular junction GO:0031672 A band GO:0031674 I band GO:0042641 actomyosin GO:0043292 contractile fiber GO:0044449 contractile fiber part

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription R-HSA-162582: Signal Transduction R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-2122947: NOTCH1 Intracellular Domain Regulates Transcription
R-HSA-162582: Signal Transduction
R-HSA-157118: Signaling by NOTCH
R-HSA-1980143: Signaling by NOTCH1
R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer
R-HSA-2644603: Signaling by NOTCH1 in Cancer

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between HDAC4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between HDAC4 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
23169640	Large B-Cell lymphoma	Inhibit immunity	Interestingly, we found that miR-155 directly targets HDAC4, a corepressor partner of BCL6. Furthermore, ectopic expression of HDAC4 in human-activated B-cell-type diffuse large B-cell lymphoma (DLBCL) cells results in reduced miR-155-induced proliferation, clonogenic potential, and increased apoptosis.

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of HDAC4 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of HDAC4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.122	0.711
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.259	0.835
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.02	0.982
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.027	0.952
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.36	0.869
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.391	0.886
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.067	0.862
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.168	0.908
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.048	0.976
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.253	0.775
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.152	0.898
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.079	0.278

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of HDAC4 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	5.9	-5.9	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	33.3	-33.3	0.231
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	2.7	4.7	0.294
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	3.4	4	0.587
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	5.9	-1.1	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	16.7	-4.2	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HDAC4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HDAC4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HDAC4. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HDAC4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of HDAC4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between HDAC4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	HDAC4
Name	histone deacetylase 4
Aliases	KIAA0288; HDAC-A; HDACA; HD4; HA6116; HDAC-4; BDMR; brachydactyly-mental retardation syndrome; AHO3; histone ......
Chromosomal Location	2q37.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting HDAC4 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting HDAC4.

ID	Name	Drug Type	Targets	#Targets
DB01593	Zinc	Small Molecule	A1BG, A2M, AGT, AHSG, ALDOA, APCS, APLP1, APLP2, APOA1, APOA2, APO ......	119
DB05015	Belinostat	Small Molecule	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, H ......	11
DB06176	Romidepsin	Small Molecule	ABCC1, HDAC1, HDAC2, HDAC4, HDAC6	5
DB06603	Panobinostat	Small Molecule	HDAC1, HDAC10, HDAC11, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, H ......	11
DB07879	N-hydroxy-5-[(3-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)carbonyl]thiophene-2-carboxamide	Small Molecule	HDAC4	1
DB08613	2,2,2-TRIFLUORO-1-{5-[(3-PHENYL-5,6-DIHYDROIMIDAZO[1,2-A]PYRAZIN-7(8H)-YL)CARBONYL]THIOPHEN-2-YL}ETHANE-1,1-DIOL	Small Molecule	HDAC4	1

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