Browse HINT1

Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Domain PF01230 HIT domain
Function

Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

> Gene Ontology
 
Biological Process GO:0006195 purine nucleotide catabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009154 purine ribonucleotide catabolic process
GO:0009166 nucleotide catabolic process
GO:0009261 ribonucleotide catabolic process
GO:0019439 aromatic compound catabolic process
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0034655 nucleobase-containing compound catabolic process
GO:0044270 cellular nitrogen compound catabolic process
GO:0046434 organophosphate catabolic process
GO:0046700 heterocycle catabolic process
GO:0050848 regulation of calcium-mediated signaling
GO:0050850 positive regulation of calcium-mediated signaling
GO:0072331 signal transduction by p53 class mediator
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:0072523 purine-containing compound catabolic process
GO:0097193 intrinsic apoptotic signaling pathway
GO:1901136 carbohydrate derivative catabolic process
GO:1901292 nucleoside phosphate catabolic process
GO:1901361 organic cyclic compound catabolic process
GO:1901565 organonitrogen compound catabolic process
Molecular Function GO:0005080 protein kinase C binding
Cellular Component GO:0000118 histone deacetylase complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HINT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HINT1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HINT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4390.0889
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3630.928
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4980.862
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0740.76
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0390.983
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.120.959
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2030.677
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2560.902
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2040.932
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.890.747
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.9480.825
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0230.795
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HINT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HINT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HINT1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HINT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HINT1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HINT1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHINT1
Namehistidine triad nucleotide binding protein 1
Aliases PKCI-1; PRKCNH1; HINT; histidine triad nucleotide-binding protein; NMAN; adenosine 5'-monophosphoramidase; p ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HINT1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HINT1.
ID Name Drug Type Targets #Targets
DB00131Adenosine monophosphateSmall MoleculeACSL1, ACSS1, ACSS2, ADCY1, ADK, CREB1, FBP1, HINT1, PDE4B, PDE4D, ......15
DB01972Guanosine-5'-MonophosphateSmall MoleculeATIC, DLG4, GMPR, GUK1, HINT1, PDE5A, TGM37
DB021625'-O-(N-Ethyl-Sulfamoyl)AdenosineSmall MoleculeHINT11
DB02183Adenosine-5'-DitungstateSmall MoleculeHINT11
DB033498-Bromo-Adenosine-5'-MonophosphateSmall MoleculeHINT1, PDE4B2