| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
| Subcellular Location | Nucleus. Chromosome. |
| Domain |
PF00125 Core histone H2A/H2B/H3/H4 |
| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; FUNCTION: Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid. |
| Biological Process |
GO:0002227 innate immune response in mucosa GO:0002251 organ or tissue specific immune response GO:0002385 mucosal immune response GO:0006323 DNA packaging GO:0006333 chromatin assembly or disassembly GO:0006334 nucleosome assembly GO:0006959 humoral immune response GO:0019730 antimicrobial humoral response GO:0019731 antibacterial humoral response GO:0031497 chromatin assembly GO:0034728 nucleosome organization GO:0042742 defense response to bacterium GO:0050830 defense response to Gram-positive bacterium GO:0065004 protein-DNA complex assembly GO:0071103 DNA conformation change GO:0071824 protein-DNA complex subunit organization GO:0098542 defense response to other organism |
| Molecular Function |
GO:0046982 protein heterodimerization activity |
| Cellular Component |
GO:0000785 chromatin GO:0000786 nucleosome GO:0000788 nuclear nucleosome GO:0000790 nuclear chromatin GO:0032993 protein-DNA complex GO:0044454 nuclear chromosome part GO:0044815 DNA packaging complex |
| KEGG | - |
| Reactome | - |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | Literatures that report relations between HIST1H2BF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
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There is no record. |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
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> High-throughput Screening
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Statistical results of HIST1H2BF in screening data sets for detecting immune reponses.
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| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
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Points in the above scatter plot represent the expression difference of HIST1H2BF in various data sets.
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There is no record. |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIST1H2BF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIST1H2BF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIST1H2BF. > Immunoinhibitor > Immunostimulator > MHC molecule |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIST1H2BF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Distribution of HIST1H2BF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
| Summary | |
|---|---|
| Symbol | HIST1H2BF |
| Name | histone cluster 1, H2bf |
| Aliases | H2BFG; H2B histone family, member G; histone 1, H2bf |
| Chromosomal Location | 6p22.2 |
| External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
| Content |
Associations between HIST1H2BF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |