Browse HIST1H3H

Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Chromosome.
Domain PF00125 Core histone H2A/H2B/H3/H4
Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

> Gene Ontology
 
Biological Process GO:0000183 chromatin silencing at rDNA
GO:0006323 DNA packaging
GO:0006333 chromatin assembly or disassembly
GO:0006334 nucleosome assembly
GO:0006335 DNA replication-dependent nucleosome assembly
GO:0006342 chromatin silencing
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0016458 gene silencing
GO:0031047 gene silencing by RNA
GO:0031497 chromatin assembly
GO:0032200 telomere organization
GO:0034723 DNA replication-dependent nucleosome organization
GO:0034728 nucleosome organization
GO:0040029 regulation of gene expression, epigenetic
GO:0045814 negative regulation of gene expression, epigenetic
GO:0045815 positive regulation of gene expression, epigenetic
GO:0050817 coagulation
GO:0050878 regulation of body fluid levels
GO:0051259 protein oligomerization
GO:0051262 protein tetramerization
GO:0051290 protein heterotetramerization
GO:0051291 protein heterooligomerization
GO:0060968 regulation of gene silencing
GO:0065004 protein-DNA complex assembly
GO:0071103 DNA conformation change
GO:0071824 protein-DNA complex subunit organization
Molecular Function GO:0003682 chromatin binding
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
GO:0042393 histone binding
GO:0043566 structure-specific DNA binding
GO:0045296 cadherin binding
GO:0046982 protein heterodimerization activity
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0000781 chromosome, telomeric region
GO:0000784 nuclear chromosome, telomeric region
GO:0000785 chromatin
GO:0000786 nucleosome
GO:0000788 nuclear nucleosome
GO:0000790 nuclear chromatin
GO:0005913 cell-cell adherens junction
GO:0032993 protein-DNA complex
GO:0044454 nuclear chromosome part
GO:0044815 DNA packaging complex
GO:0098687 chromosomal region
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HIST1H3H and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HIST1H3H in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HIST1H3H in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2030.58
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0510.954
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3970.612
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.1330.144
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.9960.51
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3220.541
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5770.314
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.8030.345
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2570.773
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.6360.000206
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HIST1H3H. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HIST1H3H. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HIST1H3H.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HIST1H3H. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HIST1H3H expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HIST1H3H and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHIST1H3H
Namehistone cluster 1, H3h
Aliases H3/k; H3F1K; H3FK; H3 histone family, member K; histone 1, H3h
Chromosomal Location6p22.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HIST1H3H collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.