Browse HMGN1

Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
Domain PF01101 HMG14 and HMG17
Function

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).

> Gene Ontology
 
Biological Process GO:0000720 pyrimidine dimer repair by nucleotide-excision repair
GO:0001654 eye development
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006289 nucleotide-excision repair
GO:0006290 pyrimidine dimer repair
GO:0006354 DNA-templated transcription, elongation
GO:0007423 sensory organ development
GO:0009314 response to radiation
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009791 post-embryonic development
GO:0009886 post-embryonic animal morphogenesis
GO:0010224 response to UV-B
GO:0010225 response to UV-C
GO:0031077 post-embryonic camera-type eye development
GO:0032784 regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0040034 regulation of development, heterochronic
GO:0043010 camera-type eye development
GO:0048050 post-embryonic eye morphogenesis
GO:0048563 post-embryonic animal organ morphogenesis
GO:0048569 post-embryonic animal organ development
GO:0048592 eye morphogenesis
GO:0048593 camera-type eye morphogenesis
GO:0048597 post-embryonic camera-type eye morphogenesis
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0090596 sensory organ morphogenesis
GO:1901664 regulation of NAD+ ADP-ribosyltransferase activity
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
Molecular Function GO:0003682 chromatin binding
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
GO:0043566 structure-specific DNA binding
Cellular Component GO:0000785 chromatin
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-73894: DNA Repair
R-HSA-6782135: Dual incision in TC-NER
R-HSA-6781823: Formation of TC-NER Pre-Incision Complex
R-HSA-6782210: Gap-filling DNA repair synthesis and ligation in TC-NER
R-HSA-5696398: Nucleotide Excision Repair
R-HSA-6781827: Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HMGN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between HMGN1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25205103lymphomaPromote immunity (T cell function)Tumor-bearing Hmgn1 / mice generated fewer OVA-specific CD8 cells in the spleen than EG7-bearing Hmgn1?/? mice, suggesting that HMGN1 supported T cell–mediated antitumor immunity.
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HMGN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HMGN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0980.641
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1010.975
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2370.922
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.160.577
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4040.859
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1440.961
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2670.573
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3580.868
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.130.956
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2820.894
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.630.848
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2710.00038
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HMGN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HMGN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HMGN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HMGN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HMGN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HMGN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHMGN1
Namehigh mobility group nucleosome binding domain 1
Aliases FLJ27265; FLJ31471; MGC104230; MGC117425; high-mobility group nucleosome binding 1; nonhistone chromosomal p ......
Chromosomal Location21q22.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HMGN1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.