Browse HNRNPH1

Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus, nucleoplasm.
Domain PF00076 RNA recognition motif. (a.k.a. RRM
PF08080 RNPHF zinc finger
Function

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).

> Gene Ontology
 
Biological Process GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0043484 regulation of RNA splicing
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0071774 response to fibroblast growth factor
Molecular Function GO:0003727 single-stranded RNA binding
GO:0008187 poly-pyrimidine tract binding
GO:0008266 poly(U) RNA binding
Cellular Component GO:0005681 spliceosomal complex
GO:0071013 catalytic step 2 spliceosome
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-6803529: FGFR2 alternative splicing
R-HSA-74160: Gene Expression
R-HSA-72203: Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162582: Signal Transduction
R-HSA-190236: Signaling by FGFR
R-HSA-5654738: Signaling by FGFR2
R-HSA-72172: mRNA Splicing
R-HSA-72163: mRNA Splicing - Major Pathway
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HNRNPH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HNRNPH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: 1.06; FDR: 0.014300 Sensitive to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HNRNPH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1960.316
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1340.967
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2380.918
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3790.202
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.370.893
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3950.913
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0890.855
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.140.952
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0160.995
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3010.905
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6510.858
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0480.319
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HNRNPH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HNRNPH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HNRNPH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HNRNPH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HNRNPH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HNRNPH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HNRNPH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHNRNPH1
Nameheterogeneous nuclear ribonucleoprotein H1 (H)
Aliases hnRNPH; HNRPH1; HNRPH; hnRNP H; Heterogeneous nuclear ribonucleoprotein H
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HNRNPH1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HNRNPH1.
ID Name Drug Type Targets #Targets
DB09130CopperSmall MoleculeA1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......141