Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF00701 Dihydrodipicolinate synthetase family |
Function |
Catalyzes the final step in the metabolic pathway of hydroxyproline. |
Biological Process |
GO:0006090 pyruvate metabolic process GO:0006575 cellular modified amino acid metabolic process GO:0009436 glyoxylate catabolic process GO:0016053 organic acid biosynthetic process GO:0016054 organic acid catabolic process GO:0019470 4-hydroxyproline catabolic process GO:0019471 4-hydroxyproline metabolic process GO:0033609 oxalate metabolic process GO:0042219 cellular modified amino acid catabolic process GO:0042866 pyruvate biosynthetic process GO:0043648 dicarboxylic acid metabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046487 glyoxylate metabolic process GO:0072329 monocarboxylic acid catabolic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process |
Molecular Function |
GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity GO:0016829 lyase activity GO:0016830 carbon-carbon lyase activity GO:0016832 aldehyde-lyase activity GO:0016833 oxo-acid-lyase activity |
Cellular Component | - |
KEGG |
hsa00330 Arginine and proline metabolism hsa00630 Glyoxylate and dicarboxylate metabolism hsa01100 Metabolic pathways |
Reactome | - |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between HOGA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of HOGA1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of HOGA1 in various data sets.
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Points in the above scatter plot represent the mutation difference of HOGA1 in various data sets.
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Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOGA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOGA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOGA1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOGA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of HOGA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between HOGA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | HOGA1 |
Name | 4-hydroxy-2-oxoglutarate aldolase 1 |
Aliases | FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ...... |
Chromosomal Location | 10q24.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting HOGA1 collected from DrugBank database. |
There is no record. |