Browse HOGA1

Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF00701 Dihydrodipicolinate synthetase family
Function

Catalyzes the final step in the metabolic pathway of hydroxyproline.

> Gene Ontology
 
Biological Process GO:0006090 pyruvate metabolic process
GO:0006575 cellular modified amino acid metabolic process
GO:0009436 glyoxylate catabolic process
GO:0016053 organic acid biosynthetic process
GO:0016054 organic acid catabolic process
GO:0019470 4-hydroxyproline catabolic process
GO:0019471 4-hydroxyproline metabolic process
GO:0033609 oxalate metabolic process
GO:0042219 cellular modified amino acid catabolic process
GO:0042866 pyruvate biosynthetic process
GO:0043648 dicarboxylic acid metabolic process
GO:0044282 small molecule catabolic process
GO:0044283 small molecule biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046395 carboxylic acid catabolic process
GO:0046487 glyoxylate metabolic process
GO:0072329 monocarboxylic acid catabolic process
GO:0072330 monocarboxylic acid biosynthetic process
GO:1901565 organonitrogen compound catabolic process
GO:1901605 alpha-amino acid metabolic process
GO:1901606 alpha-amino acid catabolic process
Molecular Function GO:0008700 4-hydroxy-2-oxoglutarate aldolase activity
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016832 aldehyde-lyase activity
GO:0016833 oxo-acid-lyase activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00330 Arginine and proline metabolism
hsa00630 Glyoxylate and dicarboxylate metabolism
hsa01100 Metabolic pathways
Reactome -
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOGA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOGA1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOGA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.2550.000921
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.8560.297
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.5590.00363
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3820.525
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1150.914
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7180.549
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.2530.643
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7180.368
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1280.881
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.970.535
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8260.689
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4440.11
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HOGA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOGA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOGA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOGA1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOGA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOGA1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOGA1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOGA1
Name4-hydroxy-2-oxoglutarate aldolase 1
Aliases FLJ37472; DHDPS2; NPL2; dihydrodipicolinate synthetase homolog 2 (E. coli); N-acetylneuraminate pyruvate lya ......
Chromosomal Location10q24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOGA1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.