TISIDB

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus.
Domain	PF00046 Homeobox domain
Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments.

> Gene Ontology [ TOP ]
Biological Process	GO:0001501 skeletal system development GO:0007423 sensory organ development GO:0007605 sensory perception of sound GO:0007632 visual behavior GO:0007634 optokinetic behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0021545 cranial nerve development GO:0021560 abducens nerve development GO:0021598 abducens nerve morphogenesis GO:0021599 abducens nerve formation GO:0021602 cranial nerve morphogenesis GO:0021603 cranial nerve formation GO:0021675 nerve development GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042473 outer ear morphogenesis GO:0043583 ear development GO:0044708 single-organism behavior GO:0048514 blood vessel morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048701 embryonic cranial skeleton morphogenesis GO:0048702 embryonic neurocranium morphogenesis GO:0048704 embryonic skeletal system morphogenesis GO:0048705 skeletal system morphogenesis GO:0048706 embryonic skeletal system development GO:0048752 semicircular canal morphogenesis GO:0048839 inner ear development GO:0048844 artery morphogenesis GO:0050795 regulation of behavior GO:0050890 cognition GO:0050905 neuromuscular process GO:0050954 sensory perception of mechanical stimulus GO:0060840 artery development GO:0060872 semicircular canal development GO:0060876 semicircular canal formation GO:0090102 cochlea development GO:0090103 cochlea morphogenesis GO:0090596 sensory organ morphogenesis GO:1904888 cranial skeletal system development
Molecular Function	-
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-5619507: Activation of HOX genes during differentiation R-HSA-5617472: Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-1266738: Developmental Biology

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between HOXA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between HOXA1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29662483	lung adenocarcinoma	Promote immunity	HOXA transcript antisense RNA myeloid-specific 1 (HOTAIRM1) is a long non-coding RNA that has been shown to be a key regulator of myeloid cell development by targeting HOXA1.
22962263	Lung Carcinoma; Melanoma	Promote immunity	A comprehensive approach using transcriptome analysis, argonaute protein immunoprecipitation, and luciferase reporter assay revealed that the genes PTPN1, HOXA1, and TP53I11 were miR-210 target genes regulated in hypoxic cells. In support of their primary importance in mediating the immunosuppressive effects of miR-210, coordinate silencing of PTPN1, HOXA1, and TP53I11 dramatically decreased tumor cell susceptibility to CTL-mediated lysis.

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of HOXA1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of HOXA1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.073	0.815
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.274	0.722
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.07	0.901
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.414	0.234
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.356	0.701
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.492	0.677
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.033	0.954
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.708	0.424
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.982	0.24
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.572	0.378
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.649	0.464
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.026	0.876

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of HOXA1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	2.7	4.7	0.294
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	3.4	4	0.587
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	9.1	0	9.1	0.458
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	16.7	0	16.7	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of HOXA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between HOXA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	HOXA1
Name	homeobox A1
Aliases	HOX1F; homeo box A1; BSAS; HOX A1 homeodomain protein; Hox 1.6-like protein; homeobox 1F; homeobox protein H ......
Chromosomal Location	7p15.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting HOXA1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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