Browse HOXA13

Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF00046 Homeobox domain
PF12284 Hox protein A13 N terminal
Function

Sequence-specific, AT-rich binding transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0007442 hindgut morphogenesis
GO:0035239 tube morphogenesis
GO:0048546 digestive tract morphogenesis
GO:0048565 digestive tract development
GO:0048619 embryonic hindgut morphogenesis
GO:0055123 digestive system development
GO:0061525 hindgut development
Molecular Function -
Cellular Component GO:0045111 intermediate filament cytoskeleton
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOXA13 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOXA13 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOXA13 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6120.0262
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.8330.0818
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4590.261
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5630.487
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3120.833
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.8890.576
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4690.561
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7190.492
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3470.788
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0630.896
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.280.654
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0140.961
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA13. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA13. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA13.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA13. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOXA13 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOXA13 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOXA13
Namehomeobox A13
Aliases HOX1J; homeo box A13; homeo box 1J; homeobox protein HOXA13; homeobox protein Hox-1J; transcription factor H ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOXA13 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.