TISIDB

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm
Domain	PF14497 Glutathione S-transferase PF02798 Glutathione S-transferase
Function	Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.

> Gene Ontology [ TOP ]
Biological Process	GO:0001516 prostaglandin biosynthetic process GO:0001676 long-chain fatty acid metabolic process GO:0002176 male germ cell proliferation GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006636 unsaturated fatty acid biosynthetic process GO:0006690 icosanoid metabolic process GO:0006692 prostanoid metabolic process GO:0006693 prostaglandin metabolic process GO:0006790 sulfur compound metabolic process GO:0007626 locomotory behavior GO:0016053 organic acid biosynthetic process GO:0019369 arachidonic acid metabolic process GO:0019371 cyclooxygenase pathway GO:0033559 unsaturated fatty acid metabolic process GO:0036093 germ cell proliferation GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0044272 sulfur compound biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046456 icosanoid biosynthetic process GO:0046457 prostanoid biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:1901685 glutathione derivative metabolic process GO:1901687 glutathione derivative biosynthetic process GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2000254 regulation of male germ cell proliferation GO:2000255 negative regulation of male germ cell proliferation
Molecular Function	GO:0000287 magnesium ion binding GO:0004364 glutathione transferase activity GO:0004667 prostaglandin-D synthase activity GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016853 isomerase activity GO:0016860 intramolecular oxidoreductase activity
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00480 Glutathione metabolism hsa00590 Arachidonic acid metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 hsa01100 Metabolic pathways
Reactome	R-HSA-2142753: Arachidonic acid metabolism R-HSA-211859: Biological oxidations R-HSA-156590: Glutathione conjugation R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-156580: Phase II conjugation R-HSA-2162123: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between HPGDS and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of HPGDS in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of HPGDS in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.109	0.743
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.187	0.754
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.049	0.92
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.281	0.555
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.337	0.739
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.226	0.818
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.966	0.0371
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-1.22	0.107
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.759	0.368
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.969	0.353
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.971	0.146
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.628	0.000396

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of HPGDS in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HPGDS. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HPGDS. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HPGDS. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HPGDS. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of HPGDS expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between HPGDS and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	HPGDS
Name	hematopoietic prostaglandin D synthase
Aliases	GSTS; H-PGDS; GSTS1-1; GSTS1; glutathione S-transferase sigma; GST class-sigma; glutathione-dependent PGD sy ......
Chromosomal Location	4q22.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting HPGDS collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting HPGDS.

ID	Name	Drug Type	Targets	#Targets
DB00143	Glutathione	Small Molecule	AKR1B1, CYP3A4, ESD, GGT1, GLO1, GLRX, GLRX2, GPX1, GPX2, GPX3, GP ......	41
DB00162	Vitamin A	Small Molecule	ALDH1A1, ALDH1A2, ALDH1A3, APOD, DHRS3, DHRS4, HPGDS, LRAT, RBP1, ......	18
DB00755	Tretinoin	Small Molecule	ALDH1A1, ALDH1A2, CYP26A1, CYP26B1, CYP26C1, GPRC5A, HPGDS, LCN1, ......	19
DB01897	2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium Chloride	Small Molecule	HPGDS	1
DB07613	3-phenyl-5-(1H-pyrazol-3-yl)isoxazole	Small Molecule	HPGDS	1
DB07614	PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLE	Small Molecule	HPGDS	1
DB07615	Tranilast	Small Molecule	HPGDS	1
DB07616	4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acid	Small Molecule	HPGDS	1
DB07917	4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINE	Small Molecule	HPGDS	1
DB08313	nocodazole	Small Molecule	HPGDS	1
DB08695	3-(4-nitrophenyl)-1H-pyrazole	Small Molecule	HPGDS	1
DB08790	1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID	Small Molecule	HPGDS	1
DB09462	Glycerin	Small Molecule	ADH1B, ARF1, GSTP1, HPGDS, ISYNA1, ITPR1, NAGA, PAEP, PAPSS1, PLA2 ......	13

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