Browse HRH1

Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

> Gene Ontology
 
Biological Process GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006066 alcohol metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007632 visual behavior
GO:0008015 blood circulation
GO:0008306 associative learning
GO:0008542 visual learning
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010919 regulation of inositol phosphate biosynthetic process
GO:0016051 carbohydrate biosynthetic process
GO:0019229 regulation of vasoconstriction
GO:0019751 polyol metabolic process
GO:0019932 second-messenger-mediated signaling
GO:0030595 leukocyte chemotaxis
GO:0032957 inositol trisphosphate metabolic process
GO:0032958 inositol phosphate biosynthetic process
GO:0032959 inositol trisphosphate biosynthetic process
GO:0032960 regulation of inositol trisphosphate biosynthetic process
GO:0032962 positive regulation of inositol trisphosphate biosynthetic process
GO:0034776 response to histamine
GO:0035150 regulation of tube size
GO:0042310 vasoconstriction
GO:0043114 regulation of vascular permeability
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043647 inositol phosphate metabolic process
GO:0044057 regulation of system process
GO:0044262 cellular carbohydrate metabolic process
GO:0044283 small molecule biosynthetic process
GO:0044708 single-organism behavior
GO:0044723 single-organism carbohydrate metabolic process
GO:0045907 positive regulation of vasoconstriction
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046173 polyol biosynthetic process
GO:0048016 inositol phosphate-mediated signaling
GO:0048167 regulation of synaptic plasticity
GO:0048245 eosinophil chemotaxis
GO:0050804 modulation of synaptic transmission
GO:0050880 regulation of blood vessel size
GO:0050890 cognition
GO:0050900 leukocyte migration
GO:0060326 cell chemotaxis
GO:0060732 positive regulation of inositol phosphate biosynthetic process
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071420 cellular response to histamine
GO:0071621 granulocyte chemotaxis
GO:0072677 eosinophil migration
GO:0090066 regulation of anatomical structure size
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
Molecular Function GO:0004969 histamine receptor activity
GO:0008227 G-protein coupled amine receptor activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04750 Inflammatory mediator regulation of TRP channels
Reactome R-HSA-375280: Amine ligand-binding receptors
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-416476: G alpha (q) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK
R-HSA-390650: Histamine receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HRH1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HRH1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HRH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.9710.0323
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.1710.196
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8180.236
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4150.149
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6920.572
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0660.965
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.130.78
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.310.75
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0430.967
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8840.339
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.380.277
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1370.296
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HRH1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.76.8-3.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.67.4-4.80.565
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HRH1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HRH1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HRH1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HRH1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HRH1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HRH1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHRH1
Namehistamine receptor H1
Aliases H1-R; H1R; HH1R; hisH1; histamine receptor, subclass H1; Histamine H1 receptor
Chromosomal Location3p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HRH1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HRH1.
ID Name Drug Type Targets #Targets
DB00215CitalopramSmall MoleculeADRA1A, CHRM1, HRH1, HTR2C, SLC6A45
DB00245BenzatropineSmall MoleculeCHRM1, HRH1, SLC6A33
DB00246ZiprasidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB00283ClemastineSmall MoleculeHRH11
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00341CetirizineSmall MoleculeHRH11
DB00342TerfenadineSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HRH1, KCNH27
DB00354BuclizineSmall MoleculeCHRM1, HRH12
DB00363ClozapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......27
DB00366DoxylamineSmall MoleculeCHRM1, HRH1, NR1I33
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00405DexbrompheniramineSmall MoleculeHRH11
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00420PromazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00427TriprolidineSmall MoleculeHRH11
DB00434CyproheptadineSmall MoleculeCHRM1, CHRM2, CHRM3, HRH1, HTR2A, HTR2C, HTR77
DB00455LoratadineSmall MoleculeHRH1, KCNH22
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00540NortriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB ......24
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00555LamotrigineSmall MoleculeADORA1, ADORA2A, ADRA1A, ADRA2A, ADRB1, CACNA1E, CHRM1, CHRM2, CHR ......44
DB00557HydroxyzineSmall MoleculeHRH11
DB00568CinnarizineSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CHR ......16
DB00637AstemizoleSmall MoleculeHRH1, KCNH1, KCNH2, MAPT4
DB00656TrazodoneSmall MoleculeADRA1A, ADRA2A, HRH1, HTR1A, HTR2A, HTR2C, SLC6A47
DB00719AzatadineSmall MoleculeHRH11
DB00726TrimipramineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......24
DB00734RisperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......15
DB00737MeclizineSmall MoleculeHRH1, NR1I32
DB00748CarbinoxamineSmall MoleculeHRH11
DB00751EpinastineSmall MoleculeADRA1A, ADRA2A, HRH1, HRH2, HTR2A, HTR76
DB00767BenzquinamideSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HRH16
DB00768OlopatadineSmall MoleculeHRH1, S100A1, S100A12, S100A13, S100A2, S100B6
DB00777PropiomazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00792TripelennamineSmall MoleculeHRH11
DB00797TolazolineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, HRH1, HRH26
DB00835BrompheniramineSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, HRH16
DB00902MethdilazineSmall MoleculeHRH11
DB00920KetotifenSmall MoleculeHRH1, PGD2
DB00934MaprotilineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......17
DB00950FexofenadineSmall MoleculeHRH11
DB00967DesloratadineSmall MoleculeHRH11
DB00972AzelastineSmall MoleculeHRH11
DB00985DimenhydrinateSmall MoleculeHRH11
DB01069PromethazineSmall MoleculeADRA1A, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, HRH1, HRH2, HTR2A10
DB01071MequitazineSmall MoleculeHRH11
DB01075DiphenhydramineSmall MoleculeCHRM2, HRH12
DB01084EmedastineSmall MoleculeHRH11
DB01106LevocabastineSmall MoleculeHRH1, NTSR22
DB01114ChlorphenamineSmall MoleculeHRH1, SLC6A2, SLC6A3, SLC6A44
DB01142DoxepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......23
DB01146DiphenylpyralineSmall MoleculeHRH1, SLC6A32
DB01151DesipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, CHRM ......21
DB01173OrphenadrineSmall MoleculeGRIN1, GRIN2D, GRIN3A, GRIN3B, HRH1, SCN10A, SLC6A27
DB01175EscitalopramSmall MoleculeADRA1A, CHRM1, HRH1, SLC6A2, SLC6A3, SLC6A46
DB01176CyclizineSmall MoleculeHRH1, SULT1E12
DB01224QuetiapineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......26
DB01237BromodiphenhydramineSmall MoleculeHRH11
DB01238AripiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB01239ChlorprothixeneSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, HRH1, HTR2A, ......12
DB01246AlimemazineSmall MoleculeHRH11
DB01267PaliperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......18
DB01403MethotrimeprazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......19
DB01615AceprometazineSmall MoleculeHRH11
DB01619PhenindamineSmall MoleculeHRH11
DB01620PheniramineSmall MoleculeHRH1, NR1I32
DB01624ZuclopenthixolSmall MoleculeADRA1A, ADRA2A, DRD1, DRD2, DRD5, HRH1, HTR2A7
DB04837ClofedanolSmall MoleculeHRH11
DB04841FlunarizineSmall MoleculeCACNA1G, CACNA1H, CACNA1I, HRH14
DB04890BepotastineSmall MoleculeHRH11
DB04905TesmilifeneSmall MoleculeABCB1, HRH12
DB04946IloperidoneSmall MoleculeADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, ......11
DB05079HY10275Small MoleculeHRH1, HTR2A2
DB05080OBE101Small MoleculeHRH1, HRH32
DB05345SO-101Small MoleculeHRH11
DB05381HistamineSmall MoleculeHRH1, HRH2, HRH3, HRH4, SLC18A25
DB05492Epicept NP-1Small MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2B ......12
DB06016CariprazineSmall MoleculeDRD2, DRD3, HRH1, HTR1A, HTR2A, HTR2B6
DB06148MianserinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......23
DB06216AsenapineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DR ......20
DB06229OcaperidoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, HRH1, HTR2A, ......11
DB06282LevocetirizineSmall MoleculeHRH11
DB06678EsmirtazapineSmall MoleculeADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2B, HTR2C7
DB06691MepyramineSmall MoleculeHRH11
DB06698BetahistineSmall MoleculeHRH1, HRH32
DB06766AlcaftadineSmall MoleculeHRH11
DB08799AntazolineSmall MoleculeHRH11
DB08800ChloropyramineSmall MoleculeHRH11
DB08801DimetindeneSmall MoleculeCHRM2, HRH12
DB08802IsothipendylSmall MoleculeHRH11
DB08922PerospironeSmall MoleculeADRA1A, ADRA1B, ADRA1D, DRD2, DRD4, HRH1, HTR1A, HTR2A8
DB08936ChlorcyclizineSmall MoleculeHRH11
DB09016ButriptylineSmall MoleculeHRH1, HTR2A, SLC6A43
DB09167DosulepinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......16
DB09194EtoperidoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......15
DB09195LorpiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, HRH1, HTR2A, HTR2C ......10
DB09488AcrivastineSmall MoleculeHRH11
DB09555Dexchlorpheniramine maleateSmall MoleculeHRH11
DB11591BilastineSmall MoleculeHRH11
DB11614RupatadineSmall MoleculeHRH1, PTAFR2
DB13025TiaprideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HRH1, ......25