Browse HSPB7

Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Nucleus, Cajal body Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
Domain PF00011 Hsp20/alpha crystallin family
Function

-

> Gene Ontology
 
Biological Process GO:0003013 circulatory system process
GO:0003015 heart process
GO:0006986 response to unfolded protein
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0035966 response to topologically incorrect protein
GO:0044057 regulation of system process
GO:0060047 heart contraction
GO:1903522 regulation of blood circulation
Molecular Function GO:0008022 protein C-terminus binding
GO:0031005 filamin binding
Cellular Component GO:0015030 Cajal body
GO:0015629 actin cytoskeleton
GO:0016234 inclusion body
GO:0016235 aggresome
GO:0016604 nuclear body
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HSPB7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HSPB7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HSPB7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1850.718
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.0680.205
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.1090.105
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2470.696
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0890.954
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.4490.821
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1990.765
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.1590.249
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.8180.438
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4230.745
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7210.66
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6680.0156
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HSPB7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSPB7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSPB7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSPB7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSPB7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HSPB7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HSPB7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHSPB7
Nameheat shock 27kDa protein family, member 7 (cardiovascular)
Aliases cvHSP; heat shock 27kD protein family, member 7 (cardiovascular); cardiovascular heat shock protein; Heat sh ......
Chromosomal Location1p36.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HSPB7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.