TISIDB

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Mitochondrion matrix.
Domain	PF00118 TCP-1/cpn60 chaperonin family
Function	Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).

> Gene Ontology [ TOP ]
Biological Process	GO:0000302 response to reactive oxygen species GO:0001666 response to hypoxia GO:0001819 positive regulation of cytokine production GO:0002200 somatic diversification of immune receptors GO:0002204 somatic recombination of immunoglobulin genes involved in immune response GO:0002208 somatic diversification of immunoglobulins involved in immune response GO:0002218 activation of innate immune response GO:0002221 pattern recognition receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002236 detection of misfolded protein GO:0002237 response to molecule of bacterial origin GO:0002250 adaptive immune response GO:0002263 cell activation involved in immune response GO:0002274 myeloid leukocyte activation GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002347 response to tumor cell GO:0002366 leukocyte activation involved in immune response GO:0002367 cytokine production involved in immune response GO:0002368 B cell cytokine production GO:0002377 immunoglobulin production GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002418 immune response to tumor cell GO:0002424 T cell mediated immune response to tumor cell GO:0002440 production of molecular mediator of immune response GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002456 T cell mediated immunity GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002697 regulation of immune effector process GO:0002699 positive regulation of immune effector process GO:0002703 regulation of leukocyte mediated immunity GO:0002705 positive regulation of leukocyte mediated immunity GO:0002706 regulation of lymphocyte mediated immunity GO:0002708 positive regulation of lymphocyte mediated immunity GO:0002709 regulation of T cell mediated immunity GO:0002711 positive regulation of T cell mediated immunity GO:0002755 MyD88-dependent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002831 regulation of response to biotic stimulus GO:0002833 positive regulation of response to biotic stimulus GO:0002834 regulation of response to tumor cell GO:0002836 positive regulation of response to tumor cell GO:0002837 regulation of immune response to tumor cell GO:0002839 positive regulation of immune response to tumor cell GO:0002840 regulation of T cell mediated immune response to tumor cell GO:0002842 positive regulation of T cell mediated immune response to tumor cell GO:0002931 response to ischemia GO:0006310 DNA recombination GO:0006457 protein folding GO:0006458 'de novo' protein folding GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006979 response to oxidative stress GO:0006986 response to unfolded protein GO:0007159 leukocyte cell-cell adhesion GO:0008637 apoptotic mitochondrial changes GO:0009266 response to temperature stimulus GO:0009306 protein secretion GO:0009408 response to heat GO:0009409 response to cold GO:0010035 response to inorganic substance GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0014074 response to purine-containing compound GO:0014823 response to activity GO:0016064 immunoglobulin mediated immune response GO:0016444 somatic cell DNA recombination GO:0016445 somatic diversification of immunoglobulins GO:0016447 somatic recombination of immunoglobulin gene segments GO:0019724 B cell mediated immunity GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0031349 positive regulation of defense response GO:0031647 regulation of protein stability GO:0031960 response to corticosteroid GO:0032103 positive regulation of response to external stimulus GO:0032479 regulation of type I interferon production GO:0032481 positive regulation of type I interferon production GO:0032496 response to lipopolysaccharide GO:0032606 type I interferon production GO:0032607 interferon-alpha production GO:0032609 interferon-gamma production GO:0032613 interleukin-10 production GO:0032615 interleukin-12 production GO:0032635 interleukin-6 production GO:0032640 tumor necrosis factor production GO:0032647 regulation of interferon-alpha production GO:0032649 regulation of interferon-gamma production GO:0032653 regulation of interleukin-10 production GO:0032655 regulation of interleukin-12 production GO:0032675 regulation of interleukin-6 production GO:0032680 regulation of tumor necrosis factor production GO:0032727 positive regulation of interferon-alpha production GO:0032729 positive regulation of interferon-gamma production GO:0032733 positive regulation of interleukin-10 production GO:0032735 positive regulation of interleukin-12 production GO:0032755 positive regulation of interleukin-6 production GO:0032760 positive regulation of tumor necrosis factor production GO:0032943 mononuclear cell proliferation GO:0033198 response to ATP GO:0035966 response to topologically incorrect protein GO:0036293 response to decreased oxygen levels GO:0042026 protein refolding GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042116 macrophage activation GO:0042220 response to cocaine GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0043030 regulation of macrophage activation GO:0043032 positive regulation of macrophage activation GO:0043279 response to alkaloid GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0043627 response to estrogen GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045190 isotype switching GO:0045785 positive regulation of cell adhesion GO:0045862 positive regulation of proteolysis GO:0046651 lymphocyte proliferation GO:0046683 response to organophosphorus GO:0048291 isotype switching to IgG isotypes GO:0048545 response to steroid hormone GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050821 protein stabilization GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051047 positive regulation of secretion GO:0051084 'de novo' posttranslational protein folding GO:0051085 chaperone mediated protein folding requiring cofactor GO:0051131 chaperone-mediated protein complex assembly GO:0051222 positive regulation of protein transport GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051384 response to glucocorticoid GO:0051402 neuron apoptotic process GO:0051604 protein maturation GO:0051788 response to misfolded protein GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061077 chaperone-mediated protein folding GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070997 neuron death GO:0071593 lymphocyte aggregation GO:0071706 tumor necrosis factor superfamily cytokine production GO:0071839 apoptotic process in bone marrow GO:0071865 regulation of apoptotic process in bone marrow GO:0071866 negative regulation of apoptotic process in bone marrow GO:0072593 reactive oxygen species metabolic process GO:0072604 interleukin-6 secretion GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903427 negative regulation of reactive oxygen species biosynthetic process GO:1903532 positive regulation of secretion by cell GO:1903555 regulation of tumor necrosis factor superfamily cytokine production GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production GO:1904467 regulation of tumor necrosis factor secretion GO:1904469 positive regulation of tumor necrosis factor secretion GO:1904951 positive regulation of establishment of protein localization GO:1990774 tumor necrosis factor secretion GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process GO:2000778 positive regulation of interleukin-6 secretion GO:2001056 positive regulation of cysteine-type endopeptidase activity
Molecular Function	GO:0001530 lipopolysaccharide binding GO:0002020 protease binding GO:0002039 p53 binding GO:0003688 DNA replication origin binding GO:0003697 single-stranded DNA binding GO:0003725 double-stranded RNA binding GO:0016887 ATPase activity GO:0017046 peptide hormone binding GO:0031625 ubiquitin protein ligase binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042562 hormone binding GO:0043559 insulin binding GO:0044389 ubiquitin-like protein ligase binding GO:0046982 protein heterodimerization activity GO:0051082 unfolded protein binding GO:0051087 chaperone binding GO:0051787 misfolded protein binding
Cellular Component	GO:0000307 cyclin-dependent protein kinase holoenzyme complex GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix GO:0005769 early endosome GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0005791 rough endoplasmic reticulum GO:0005905 clathrin-coated pit GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex GO:0030061 mitochondrial crista GO:0030135 coated vesicle GO:0030141 secretory granule GO:0031907 microbody lumen GO:0032806 carboxy-terminal domain protein kinase complex GO:0042579 microbody GO:0042588 zymogen granule GO:0043209 myelin sheath GO:0043235 receptor complex GO:0044438 microbody part GO:0044439 peroxisomal part GO:0044455 mitochondrial membrane part GO:0045121 membrane raft GO:0046696 lipopolysaccharide receptor complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0098589 membrane region GO:0098857 membrane microdomain GO:0099503 secretory vesicle GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa03018 RNA degradation
Reactome	R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-392499: Metabolism of proteins R-HSA-1268020: Mitochondrial protein import R-HSA-8869496: TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between HSPD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between HSPD1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
22396543	Hepatocellular Carcinoma	Promote immunity (NK cell function)	ELISA results showed that the production of HSP60, HSP70, and HSP90 was up-regulated in both cell lines in a stress-specific manner. Acting as a decoy, the HSP-bearing exosomes efficiently stimulated NK cell cytotoxicity and granzyme B production, up-regulated the expression of inhibitory receptor CD94, and down-regulated the expression of activating receptors CD69, NKG2D, and NKp44.

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of HSPD1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of HSPD1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.071	0.801
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.116	0.973
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.215	0.935
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.019	0.954
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.331	0.883
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.463	0.874
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.048	0.934
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.221	0.931
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.395	0.886
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.333	0.891
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.179	0.962
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.065	0.473

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of HSPD1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	0	2.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HSPD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HSPD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HSPD1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HSPD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of HSPD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between HSPD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	HSPD1
Name	heat shock 60kDa protein 1 (chaperonin)
Aliases	GroEL; HSP60; SPG13; heat shock 60kD protein 1 (chaperonin); spastic paraplegia 13 (autosomal dominant); CPN ......
Chromosomal Location	2q33.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting HSPD1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting HSPD1.

ID	Name	Drug Type	Targets	#Targets
DB09130	Copper	Small Molecule	A1BG, ACTG1, ACTN1, ACY1, AFM, AGT, AHCY, AHSG, AKR1A1, ANXA4, ANX ......	141

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