Browse HTR1D

Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity. May also play a role in regulating the release of other neurotransmitters. May play a role in vasoconstriction.

> Gene Ontology
 
Biological Process GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007210 serotonin receptor signaling pathway
GO:0008015 blood circulation
GO:0009636 response to toxic substance
GO:0014821 phasic smooth muscle contraction
GO:0014827 intestine smooth muscle contraction
GO:0014831 gastro-intestinal system smooth muscle contraction
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0035150 regulation of tube size
GO:0042310 vasoconstriction
GO:0042493 response to drug
GO:0050795 regulation of behavior
GO:0050880 regulation of blood vessel size
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055074 calcium ion homeostasis
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090066 regulation of anatomical structure size
GO:0097553 calcium ion transmembrane import into cytosol
GO:1902656 calcium ion import into cytosol
GO:2000021 regulation of ion homeostasis
Molecular Function GO:0004993 G-protein coupled serotonin receptor activity
GO:0008227 G-protein coupled amine receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0043176 amine binding
GO:0051378 serotonin binding
GO:0099589 serotonin receptor activity
Cellular Component GO:0030425 dendrite
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04726 Serotonergic synapse
hsa04742 Taste transduction
Reactome R-HSA-375280: Amine ligand-binding receptors
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418594: G alpha (i) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-390666: Serotonin receptors
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HTR1D and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HTR1D in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA Resistant to T cell-mediated killing
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HTR1D in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0020.997
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.3080.781
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.3860.777
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2080.625
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2080.745
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.140.608
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of HTR1D in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HTR1D. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HTR1D. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HTR1D.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HTR1D. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HTR1D expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HTR1D and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHTR1D
Name5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Aliases RDC4; HT1DA; 5-HT1D; HTRL; 5-hydroxytryptamine (serotonin) receptor 1D; HT1DAA; 5-HT-1D; 5-HT-1D-alpha; sero ......
Chromosomal Location1p36.3-p34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HTR1D collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting HTR1D.
ID Name Drug Type Targets #Targets
DB00216EletriptanSmall MoleculeHTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2B, HTR77
DB00246ZiprasidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB00248CabergolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......22
DB00268RopiniroleSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......14
DB00315ZolmitriptanSmall MoleculeHTR1A, HTR1B, HTR1D, HTR1F4
DB00320DihydroergotamineSmall MoleculeADRA2A, HTR1B, HTR1D, HTR2B4
DB00321AmitriptylineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......35
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00363ClozapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......27
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00413PramipexoleSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......14
DB00589LisurideSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......15
DB00669SumatriptanSmall MoleculeHTR1A, HTR1B, HTR1D, HTR1F4
DB00696ErgotamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, DRD5, HTR1A, H ......16
DB00714ApomorphineSmall MoleculeADRA2A, ADRA2B, ADRA2C, CALY, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, ......15
DB00726TrimipramineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......24
DB00734RisperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......15
DB00918AlmotriptanSmall MoleculeHTR1B, HTR1D2
DB00952NaratriptanSmall MoleculeHTR1A, HTR1B, HTR1D, HTR1F4
DB00953RizatriptanSmall MoleculeHTR1B, HTR1D, HTR1F3
DB00998FrovatriptanSmall MoleculeHTR1B, HTR1D2
DB01049Ergoloid mesylateSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......41
DB01186PergolideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......17
DB01200BromocriptineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......18
DB01221KetamineSmall MoleculeBCHE, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD2, GRIN3A, HTR1A, HTR1 ......23
DB01224QuetiapineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......26
DB01238AripiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB01267PaliperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......18
DB01392YohimbineSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HTR1A, HTR1B, HTR1D, HTR2A, HT ......18
DB06096NXN-188Small MoleculeHTR1B, HTR1D, NOS13
DB09304SetiptilineSmall MoleculeADRA2A, ADRA2B, ADRA2C, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, ......19
DB13025TiaprideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD2, DRD3, HRH1, ......25