Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF00010 Helix-loop-helix DNA-binding domain |
Function |
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. |
Biological Process |
GO:0000082 G1/S transition of mitotic cell cycle GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001779 natural killer cell differentiation GO:0001822 kidney development GO:0001966 thigmotaxis GO:0002262 myeloid cell homeostasis GO:0002521 leukocyte differentiation GO:0002573 myeloid leukocyte differentiation GO:0002683 negative regulation of immune system process GO:0002694 regulation of leukocyte activation GO:0002695 negative regulation of leukocyte activation GO:0002761 regulation of myeloid leukocyte differentiation GO:0002763 positive regulation of myeloid leukocyte differentiation GO:0003007 heart morphogenesis GO:0003013 circulatory system process GO:0003149 membranous septum morphogenesis GO:0003161 cardiac conduction system development GO:0003164 His-Purkinje system development GO:0003166 bundle of His development GO:0003205 cardiac chamber development GO:0003206 cardiac chamber morphogenesis GO:0003229 ventricular cardiac muscle tissue development GO:0003231 cardiac ventricle development GO:0003279 cardiac septum development GO:0003281 ventricular septum development GO:0007050 cell cycle arrest GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0007568 aging GO:0007569 cell aging GO:0007622 rhythmic behavior GO:0007623 circadian rhythm GO:0007626 locomotory behavior GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0008344 adult locomotory behavior GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009648 photoperiodism GO:0009649 entrainment of circadian clock GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010226 response to lithium ion GO:0010720 positive regulation of cell development GO:0010721 negative regulation of cell development GO:0014003 oligodendrocyte development GO:0014013 regulation of gliogenesis GO:0014014 negative regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014706 striated muscle tissue development GO:0019216 regulation of lipid metabolic process GO:0021537 telencephalon development GO:0021700 developmental maturation GO:0021772 olfactory bulb development GO:0021782 glial cell development GO:0021988 olfactory lobe development GO:0030098 lymphocyte differentiation GO:0030099 myeloid cell differentiation GO:0030101 natural killer cell activation GO:0030183 B cell differentiation GO:0030218 erythrocyte differentiation GO:0030225 macrophage differentiation GO:0030278 regulation of ossification GO:0030279 negative regulation of ossification GO:0030534 adult behavior GO:0030879 mammary gland development GO:0030900 forebrain development GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032922 circadian regulation of gene expression GO:0033002 muscle cell proliferation GO:0033598 mammary gland epithelial cell proliferation GO:0034101 erythrocyte homeostasis GO:0035239 tube morphogenesis GO:0042063 gliogenesis GO:0042113 B cell activation GO:0042752 regulation of circadian rhythm GO:0043153 entrainment of circadian clock by photoperiod GO:0043353 enucleate erythrocyte differentiation GO:0043392 negative regulation of DNA binding GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity GO:0044708 single-organism behavior GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045165 cell fate commitment GO:0045444 fat cell differentiation GO:0045475 locomotor rhythm GO:0045577 regulation of B cell differentiation GO:0045578 negative regulation of B cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045619 regulation of lymphocyte differentiation GO:0045620 negative regulation of lymphocyte differentiation GO:0045637 regulation of myeloid cell differentiation GO:0045639 positive regulation of myeloid cell differentiation GO:0045646 regulation of erythrocyte differentiation GO:0045648 positive regulation of erythrocyte differentiation GO:0045649 regulation of macrophage differentiation GO:0045651 positive regulation of macrophage differentiation GO:0045665 negative regulation of neuron differentiation GO:0045667 regulation of osteoblast differentiation GO:0045668 negative regulation of osteoblast differentiation GO:0045685 regulation of glial cell differentiation GO:0045686 negative regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045777 positive regulation of blood pressure GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0048469 cell maturation GO:0048511 rhythmic process GO:0048512 circadian behavior GO:0048537 mucosal-associated lymphoid tissue development GO:0048541 Peyer's patch development GO:0048546 digestive tract morphogenesis GO:0048557 embryonic digestive tract morphogenesis GO:0048562 embryonic organ morphogenesis GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048663 neuron fate commitment GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048708 astrocyte differentiation GO:0048709 oligodendrocyte differentiation GO:0048710 regulation of astrocyte differentiation GO:0048711 positive regulation of astrocyte differentiation GO:0048713 regulation of oligodendrocyte differentiation GO:0048715 negative regulation of oligodendrocyte differentiation GO:0048732 gland development GO:0048738 cardiac muscle tissue development GO:0048872 homeostasis of number of cells GO:0050673 epithelial cell proliferation GO:0050768 negative regulation of neurogenesis GO:0050769 positive regulation of neurogenesis GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050866 negative regulation of cell activation GO:0050869 negative regulation of B cell activation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051101 regulation of DNA binding GO:0051249 regulation of lymphocyte activation GO:0051250 negative regulation of lymphocyte activation GO:0051961 negative regulation of nervous system development GO:0051962 positive regulation of nervous system development GO:0055123 digestive system development GO:0060411 cardiac septum morphogenesis GO:0060412 ventricular septum morphogenesis GO:0060537 muscle tissue development GO:0060612 adipose tissue development GO:0060644 mammary gland epithelial cell differentiation GO:0060749 mammary gland alveolus development GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development GO:0061031 endodermal digestive tract morphogenesis GO:0061180 mammary gland epithelium development GO:0061351 neural precursor cell proliferation GO:0061377 mammary gland lobule development GO:0061448 connective tissue development GO:0071156 regulation of cell cycle arrest GO:0071158 positive regulation of cell cycle arrest GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071285 cellular response to lithium ion GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0072001 renal system development GO:0090068 positive regulation of cell cycle process GO:0090398 cellular senescence GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1902105 regulation of leukocyte differentiation GO:1902106 negative regulation of leukocyte differentiation GO:1902107 positive regulation of leukocyte differentiation GO:1902806 regulation of cell cycle G1/S phase transition GO:1903706 regulation of hemopoiesis GO:1903707 negative regulation of hemopoiesis GO:1903708 positive regulation of hemopoiesis GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000177 regulation of neural precursor cell proliferation GO:2000178 negative regulation of neural precursor cell proliferation |
Molecular Function |
GO:0044325 ion channel binding |
Cellular Component |
GO:0005813 centrosome |
KEGG |
hsa04350 TGF-beta signaling pathway hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome | - |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ID2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ID2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ID2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ID2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ID2 in various data sets.
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Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ID2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ID2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ID2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ID2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ID2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ID2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ID2 |
Name | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
Aliases | GIG8; bHLHb26; cell growth-inhibiting gene 8; GIG8A; ID2H; DNA-binding protein inhibitor ID2; class B basic ...... |
Chromosomal Location | 2p25 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ID2 collected from DrugBank database. |
There is no record. |