Browse IFIT3

Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Mitochondrion.
Domain PF13176 Tetratricopeptide repeat
PF13181 Tetratricopeptide repeat
Function

IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.

> Gene Ontology
 
Biological Process GO:0009615 response to virus
GO:0034340 response to type I interferon
GO:0035455 response to interferon-alpha
GO:0035457 cellular response to interferon-alpha
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0071357 cellular response to type I interferon
GO:0098542 defense response to other organism
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IFIT3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IFIT3 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28295457Hepatocellular CarcinomaPromote immunity (T cell function)We found that higher expression of IFIT3, but not other IFITs, in HCC tissues predicts better response to IFN-α therapy, suggesting that IFIT3 may be a useful predictor of the response to IFN-α therapy in HCC patients. Mechanistically, IFIT3 enhanced the antitumor effects of IFN-α by promoting IFN-α effector responses both in vitro and in vivo. IFIT3 could bind signal transducer and activator of transcription 1 (STAT1) and STAT2 to enhance STAT1-STAT2 heterodimerization and nuclear translocation upon IFN-α treatment, thus promoting IFN-α effector signaling.
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IFIT3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IFIT3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0890.815
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.6680.748
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3360.83
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.190.715
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.280.865
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0820.97
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2250.651
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5490.743
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1960.92
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.5280.384
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.210.664
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.2890.113
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFIT3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFIT3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFIT3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFIT3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IFIT3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IFIT3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIFIT3
Nameinterferon-induced protein with tetratricopeptide repeats 3
Aliases ISG60; RIG-G; CIG-49; IFI60; GARG-49; IRG2; IFIT4; interferon-induced protein with tetratricopeptide repeats ......
Chromosomal Location10q23.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IFIT3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.