Browse IFNA2

Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00143 Interferon alpha/beta domain
Function

Produced by macrophages, IFN-alpha have antiviral activities.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002250 adaptive immune response
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002286 T cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002367 cytokine production involved in immune response
GO:0002369 T cell cytokine production
GO:0002440 production of molecular mediator of immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002456 T cell mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002700 regulation of production of molecular mediator of immune response
GO:0002701 negative regulation of production of molecular mediator of immune response
GO:0002703 regulation of leukocyte mediated immunity
GO:0002704 negative regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002707 negative regulation of lymphocyte mediated immunity
GO:0002709 regulation of T cell mediated immunity
GO:0002710 negative regulation of T cell mediated immunity
GO:0002718 regulation of cytokine production involved in immune response
GO:0002719 negative regulation of cytokine production involved in immune response
GO:0002724 regulation of T cell cytokine production
GO:0002725 negative regulation of T cell cytokine production
GO:0002819 regulation of adaptive immune response
GO:0002820 negative regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002828 regulation of type 2 immune response
GO:0002829 negative regulation of type 2 immune response
GO:0006959 humoral immune response
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0009306 protein secretion
GO:0009615 response to virus
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0019058 viral life cycle
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0030098 lymphocyte differentiation
GO:0030101 natural killer cell activation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030260 entry into host cell
GO:0032616 interleukin-13 production
GO:0032634 interleukin-5 production
GO:0032656 regulation of interleukin-13 production
GO:0032674 regulation of interleukin-5 production
GO:0032696 negative regulation of interleukin-13 production
GO:0032714 negative regulation of interleukin-5 production
GO:0032943 mononuclear cell proliferation
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033139 regulation of peptidyl-serine phosphorylation of STAT protein
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0034340 response to type I interferon
GO:0035743 CD4-positive, alpha-beta T cell cytokine production
GO:0035745 T-helper 2 cell cytokine production
GO:0042092 type 2 immune response
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042501 serine phosphorylation of STAT protein
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0043330 response to exogenous dsRNA
GO:0043331 response to dsRNA
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044409 entry into host
GO:0045088 regulation of innate immune response
GO:0045580 regulation of T cell differentiation
GO:0045581 negative regulation of T cell differentiation
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046596 regulation of viral entry into host cell
GO:0046597 negative regulation of viral entry into host cell
GO:0046651 lymphocyte proliferation
GO:0046718 viral entry into host cell
GO:0048525 negative regulation of viral process
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050777 negative regulation of immune response
GO:0050792 regulation of viral process
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0050868 negative regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051224 negative regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0051607 defense response to virus
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0060759 regulation of response to cytokine stimulus
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0071357 cellular response to type I interferon
GO:0071593 lymphocyte aggregation
GO:0072603 interleukin-5 secretion
GO:0072611 interleukin-13 secretion
GO:0097696 STAT cascade
GO:0098542 defense response to other organism
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903038 negative regulation of leukocyte cell-cell adhesion
GO:1903531 negative regulation of secretion by cell
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1904950 negative regulation of establishment of protein localization
GO:2000551 regulation of T-helper 2 cell cytokine production
GO:2000552 negative regulation of T-helper 2 cell cytokine production
GO:2000662 regulation of interleukin-5 secretion
GO:2000663 negative regulation of interleukin-5 secretion
GO:2000665 regulation of interleukin-13 secretion
GO:2000666 negative regulation of interleukin-13 secretion
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04060 Cytokine-cytokine receptor interaction
hsa04151 PI3K-Akt signaling pathway
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa04630 Jak-STAT signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-109582: Hemostasis
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-912694: Regulation of IFNA signaling
R-HSA-933541: TRAF6 mediated IRF7 activation
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IFNA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IFNA2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
18995891Ovarian CarcinomaPromote immunityIFNalpha-2b showed an inhibitory effect on OC cell proliferation. IFNalpha-2b had a synergistic effect with IL-2 and PBMC increasing the cytotoxicity by an average of 20%.
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IFNA2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IFNA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6770.585
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.9420.281
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9080.689
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0990.494
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IFNA2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFNA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFNA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFNA2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFNA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IFNA2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IFNA2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIFNA2
Nameinterferon, alpha 2
Aliases IFN-alphaA; alpha-2a interferon; interferon alpha 2b; interferon alpha A; IFNAB; INFA2; IFN-alpha-2; interfe ......
Chromosomal Location9p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IFNA2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting IFNA2.
ID Name Drug Type Targets #Targets
DB12773SifalimumabBiotechIFNA21