TISIDB

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cell membrane Single-pass type I membrane protein
Domain	PF07140 Interferon gamma receptor (IFNGR1) PF01108 Tissue factor
Function	Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460). Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114). Plays an essential role in the IFN-gamma pathway that is required for the cellular response to infectious agents (PubMed:20015550).

> Gene Ontology [ TOP ]
Biological Process	GO:0001959 regulation of cytokine-mediated signaling pathway GO:0009615 response to virus GO:0034341 response to interferon-gamma GO:0045088 regulation of innate immune response GO:0060330 regulation of response to interferon-gamma GO:0060333 interferon-gamma-mediated signaling pathway GO:0060334 regulation of interferon-gamma-mediated signaling pathway GO:0060759 regulation of response to cytokine stimulus GO:0071346 cellular response to interferon-gamma
Molecular Function	GO:0004896 cytokine receptor activity GO:0004904 interferon receptor activity GO:0004906 interferon-gamma receptor activity GO:0019955 cytokine binding GO:0042015 interleukin-20 binding
Cellular Component	GO:0014069 postsynaptic density GO:0030425 dendrite GO:0060076 excitatory synapse GO:0098794 postsynapse GO:0099572 postsynaptic specialization

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04060 Cytokine-cytokine receptor interaction hsa04066 HIF-1 signaling pathway hsa04380 Osteoclast differentiation hsa04630 Jak-STAT signaling pathway hsa04650 Natural killer cell mediated cytotoxicity
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-877300: Interferon gamma signaling R-HSA-877312: Regulation of IFNG signaling

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IFNGR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between IFNGR1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
29090321	Hepatocellular Carcinoma	Inhibit immunity (T cell function)	In the present study, we asked whether TNF-α can promote the expression of B7-H1 induced by IFN-γ in HCC cells. We found that JAK/STAT1/IRF1 was the primary pathway responsible for induction of B7-H1 expression by IFN-γ in human HCC cell lines. TNF-α and IFN-γ synergistically induced the expression of B7-H1 in the HCC cells. Moreover, the mechanism of the synergy was that TNF-α enhanced IFN-γ signaling by upregulating the expression of IFN-γ receptors.
17918178	Metastatic Malignant Neoplasm in the Lung; Breast Carcinoma	Inhibit immunity (infiltration)	Interestingly, disruption of IFN-gammaR function did not alter tumor cell susceptibility to CTL-mediated cytotoxicity, but is linked to enhanced infiltration of endogenous T cells in the tumor microenvironment in vivo.

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of IFNGR1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: 4.68; FDR: 0.000150	Sensitive to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	logFC: 3.44; FDR: 0.000381	Sensitive to T cell-mediated killing
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	STARS Score: 6.97; FDR: 0.000	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of IFNGR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.341	0.337
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.242	0.919
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.414	0.814
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.168	0.713
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.704	0.672
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.51	0.81
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.146	0.755
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.338	0.858
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.05	0.981
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.476	0.797
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.983	0.734
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.359	2.42e-05

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of IFNGR1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	0	3.7	0.27
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	0	3.7	0.314
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	16.7	-16.7	0.429
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IFNGR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IFNGR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IFNGR1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IFNGR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IFNGR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IFNGR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	IFNGR1
Name	interferon gamma receptor 1
Aliases	CD119; IFNGR; IMD27A; IMD27B; AVP, type 2; CD119 antigen; CDw119; IFN-gamma receptor 1; IFN-gamma-R1; antivi ......
Chromosomal Location	6q23-q24
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IFNGR1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting IFNGR1.

ID	Name	Drug Type	Targets	#Targets
DB00033	Interferon gamma-1b	Biotech	IFNGR1, IFNGR2	2

Browse IFNGR1