Browse IGFBP5

Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00219 Insulin-like growth factor binding protein
PF00086 Thyroglobulin type-1 repeat
Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001942 hair follicle development
GO:0003012 muscle system process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006109 regulation of carbohydrate metabolic process
GO:0006417 regulation of translation
GO:0007565 female pregnancy
GO:0007568 aging
GO:0008544 epidermis development
GO:0010608 posttranscriptional regulation of gene expression
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010906 regulation of glucose metabolic process
GO:0014074 response to purine-containing compound
GO:0014733 regulation of skeletal muscle adaptation
GO:0014734 skeletal muscle hypertrophy
GO:0014741 negative regulation of muscle hypertrophy
GO:0014743 regulation of muscle hypertrophy
GO:0014745 negative regulation of muscle adaptation
GO:0014812 muscle cell migration
GO:0014888 striated muscle adaptation
GO:0014896 muscle hypertrophy
GO:0014897 striated muscle hypertrophy
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014912 negative regulation of smooth muscle cell migration
GO:0016049 cell growth
GO:0017148 negative regulation of translation
GO:0019318 hexose metabolic process
GO:0022404 molting cycle process
GO:0022405 hair cycle process
GO:0022612 gland morphogenesis
GO:0030278 regulation of ossification
GO:0030279 negative regulation of ossification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030336 negative regulation of cell migration
GO:0030879 mammary gland development
GO:0031069 hair follicle morphogenesis
GO:0033002 muscle cell proliferation
GO:0033500 carbohydrate homeostasis
GO:0034248 regulation of cellular amide metabolic process
GO:0034249 negative regulation of cellular amide metabolic process
GO:0040013 negative regulation of locomotion
GO:0042303 molting cycle
GO:0042593 glucose homeostasis
GO:0042633 hair cycle
GO:0042692 muscle cell differentiation
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043500 muscle adaptation
GO:0043501 skeletal muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0043567 regulation of insulin-like growth factor receptor signaling pathway
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0043588 skin development
GO:0044057 regulation of system process
GO:0044262 cellular carbohydrate metabolic process
GO:0044342 type B pancreatic cell proliferation
GO:0044706 multi-multicellular organism process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045667 regulation of osteoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045926 negative regulation of growth
GO:0046683 response to organophosphorus
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048286 lung alveolus development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0048730 epidermis morphogenesis
GO:0048732 gland development
GO:0048771 tissue remodeling
GO:0050673 epithelial cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051271 negative regulation of cellular component movement
GO:0051591 response to cAMP
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0060056 mammary gland involution
GO:0060416 response to growth hormone
GO:0060443 mammary gland morphogenesis
GO:0060537 muscle tissue development
GO:0060541 respiratory system development
GO:0071320 cellular response to cAMP
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0090257 regulation of muscle system process
GO:0098773 skin epidermis development
GO:1901652 response to peptide
GO:1901861 regulation of muscle tissue development
GO:1901862 negative regulation of muscle tissue development
GO:1904204 regulation of skeletal muscle hypertrophy
GO:1904205 negative regulation of skeletal muscle hypertrophy
GO:2000146 negative regulation of cell motility
Molecular Function GO:0001968 fibronectin binding
GO:0005520 insulin-like growth factor binding
GO:0019838 growth factor binding
GO:0031994 insulin-like growth factor I binding
GO:0031995 insulin-like growth factor II binding
Cellular Component GO:0016942 insulin-like growth factor binding protein complex
GO:0036454 growth factor complex
GO:0042567 insulin-like growth factor ternary complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-381426: Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IGFBP5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IGFBP5 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IGFBP5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.5150.038
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-2.50.337
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7820.665
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3980.508
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0170.995
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.9190.77
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.7730.273
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8980.696
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7580.753
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1710.625
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.5730.447
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.570.0267
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IGFBP5 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGFBP5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGFBP5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGFBP5.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGFBP5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IGFBP5 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IGFBP5 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIGFBP5
Nameinsulin-like growth factor binding protein 5
Aliases IBP5; IBP-5; IGF-binding protein 5; IGFBP-5; Insulin-like growth factor-binding protein 5
Chromosomal Location2q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IGFBP5 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.