TISIDB

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Secreted
Domain	PF07654 Immunoglobulin C1-set domain
Function	-

> Gene Ontology [ TOP ]
Biological Process	GO:0002250 adaptive immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002443 leukocyte mediated immunity GO:0002449 lymphocyte mediated immunity GO:0002455 humoral immune response mediated by circulating immunoglobulin GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006909 phagocytosis GO:0006910 phagocytosis, recognition GO:0006911 phagocytosis, engulfment GO:0006956 complement activation GO:0006958 complement activation, classical pathway GO:0006959 humoral immune response GO:0008037 cell recognition GO:0010324 membrane invagination GO:0016064 immunoglobulin mediated immune response GO:0019724 B cell mediated immunity GO:0042113 B cell activation GO:0042742 defense response to bacterium GO:0050851 antigen receptor-mediated signaling pathway GO:0050853 B cell receptor signaling pathway GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050871 positive regulation of B cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0072376 protein activation cascade GO:0098542 defense response to other organism GO:0099024 plasma membrane invagination
Molecular Function	GO:0003823 antigen binding GO:0034987 immunoglobulin receptor binding
Cellular Component	GO:0009897 external side of plasma membrane GO:0019814 immunoglobulin complex GO:0042571 immunoglobulin complex, circulating GO:0072562 blood microparticle GO:0098552 side of membrane

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IGLL5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of IGLL5 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of IGLL5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.299	0.831
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.489	0.633
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-1.603	0.513
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	1.05	0.281
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.707	0.665
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	1.505	0.528
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.645	0.534
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	2.222	0.349
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.922	0.704
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	4.032	0.0498
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	3.156	0.308
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.114	0.77

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of IGLL5 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	7.1	-7.1	0.467
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IGLL5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IGLL5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IGLL5. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IGLL5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IGLL5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IGLL5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	IGLL5
Name	immunoglobulin lambda-like polypeptide 5
Aliases	VL-MAR; G lambda-1; anti HBs antibody light-chain Fab fragment; germline immunoglobulin lambda 1; immunoglob ......
Chromosomal Location	22q11.22
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IGLL5 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse IGLL5