TISIDB

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Nucleus Membrane raft Note=Colocalized with DPP4 in membrane rafts.
Domain	PF12179 I-kappa-kinase-beta NEMO binding domain PF00069 Protein kinase domain
Function	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation.

> Gene Ontology [ TOP ]
Biological Process	GO:0001885 endothelial cell development GO:0001959 regulation of cytokine-mediated signaling pathway GO:0002064 epithelial cell development GO:0002218 activation of innate immune response GO:0002220 innate immune response activating cell surface receptor signaling pathway GO:0002221 pattern recognition receptor signaling pathway GO:0002223 stimulatory C-type lectin receptor signaling pathway GO:0002224 toll-like receptor signaling pathway GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002753 cytoplasmic pattern recognition receptor signaling pathway GO:0002756 MyD88-independent toll-like receptor signaling pathway GO:0002757 immune response-activating signal transduction GO:0002758 innate immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003158 endothelium development GO:0006470 protein dephosphorylation GO:0007009 plasma membrane organization GO:0007043 cell-cell junction assembly GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007252 I-kappaB phosphorylation GO:0009615 response to virus GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway GO:0010921 regulation of phosphatase activity GO:0010923 negative regulation of phosphatase activity GO:0016311 dephosphorylation GO:0018105 peptidyl-serine phosphorylation GO:0018209 peptidyl-serine modification GO:0030522 intracellular receptor signaling pathway GO:0030856 regulation of epithelial cell differentiation GO:0030865 cortical cytoskeleton organization GO:0030866 cortical actin cytoskeleton organization GO:0031098 stress-activated protein kinase signaling cascade GO:0031349 positive regulation of defense response GO:0032515 negative regulation of phosphoprotein phosphatase activity GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034612 response to tumor necrosis factor GO:0035303 regulation of dephosphorylation GO:0035304 regulation of protein dephosphorylation GO:0035305 negative regulation of dephosphorylation GO:0035308 negative regulation of protein dephosphorylation GO:0035507 regulation of myosin-light-chain-phosphatase activity GO:0035509 negative regulation of myosin-light-chain-phosphatase activity GO:0035666 TRIF-dependent toll-like receptor signaling pathway GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042501 serine phosphorylation of STAT protein GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043297 apical junction assembly GO:0043666 regulation of phosphoprotein phosphatase activity GO:0045088 regulation of innate immune response GO:0045089 positive regulation of innate immune response GO:0045216 cell-cell junction organization GO:0045446 endothelial cell differentiation GO:0045601 regulation of endothelial cell differentiation GO:0046425 regulation of JAK-STAT cascade GO:0050851 antigen receptor-mediated signaling pathway GO:0050852 T cell receptor signaling pathway GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051346 negative regulation of hydrolase activity GO:0051403 stress-activated MAPK cascade GO:0060759 regulation of response to cytokine stimulus GO:0061028 establishment of endothelial barrier GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0070830 bicellular tight junction assembly GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090150 establishment of protein localization to membrane GO:1901550 regulation of endothelial cell development GO:1901888 regulation of cell junction assembly GO:1901889 negative regulation of cell junction assembly GO:1903140 regulation of establishment of endothelial barrier GO:1903347 negative regulation of bicellular tight junction assembly GO:1904892 regulation of STAT cascade GO:1990778 protein localization to cell periphery GO:2000810 regulation of bicellular tight junction assembly
Molecular Function	GO:0004674 protein serine/threonine kinase activity GO:0008384 IkappaB kinase activity GO:0046982 protein heterodimerization activity GO:0097110 scaffold protein binding
Cellular Component	GO:0008385 IkappaB kinase complex GO:0009898 cytoplasmic side of plasma membrane GO:0035631 CD40 receptor complex GO:0043235 receptor complex GO:0044445 cytosolic part GO:0045121 membrane raft GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane GO:0098589 membrane region GO:0098802 plasma membrane receptor complex GO:0098857 membrane microdomain GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04014 Ras signaling pathway hsa04062 Chemokine signaling pathway hsa04064 NF-kappa B signaling pathway hsa04068 FoxO signaling pathway hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04210 Apoptosis hsa04380 Osteoclast differentiation hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04623 Cytosolic DNA-sensing pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04910 Insulin signaling pathway hsa04920 Adipocytokine signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-1169091: Activation of NF-kappaB in B cells R-HSA-1280218: Adaptive Immune System R-HSA-1236975: Antigen processing-Cross presentation R-HSA-5621481: C-type lectin receptors (CLRs) R-HSA-5607764: CLEC7A (Dectin-1) signaling R-HSA-983169: Class I MHC mediated antigen processing & presentation R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA R-HSA-73887: Death Receptor Signalling R-HSA-1643685: Disease R-HSA-5602358: Diseases associated with the TLR signaling cascade R-HSA-5260271: Diseases of Immune System R-HSA-202424: Downstream TCR signaling R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-1236974: ER-Phagosome pathway R-HSA-2871837: FCERI mediated NF-kB activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) R-HSA-937041: IKK complex recruitment mediated by RIP1 R-HSA-937039: IRAK1 recruits IKK complex R-HSA-975144: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-5603029: IkBA variant leads to EDA-ID R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-446652: Interleukin-1 signaling R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-5684264: MAP3K8 (TPL2)-dependent MAPK1/3 activation R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-209560: NF-kB is activated and signals survival R-HSA-168638: NOD1/2 Signaling Pathway R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476: RIP-mediated NFkB activation via ZBP1 R-HSA-5357905: Regulation of TNFR1 signaling R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-202403: TCR signaling R-HSA-75893: TNF signaling R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-933542: TRAF6 mediated NF-kB activation R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs R-HSA-193704: p75 NTR receptor-mediated signalling R-HSA-209543: p75NTR recruits signalling complexes R-HSA-193639: p75NTR signals via NF-kB

> KEGG and Reactome Pathway

[ TOP ]

KEGG

hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04062 Chemokine signaling pathway
hsa04064 NF-kappa B signaling pathway
hsa04068 FoxO signaling pathway
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04210 Apoptosis
hsa04380 Osteoclast differentiation
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04668 TNF signaling pathway
hsa04722 Neurotrophin signaling pathway
hsa04910 Insulin signaling pathway
hsa04920 Adipocytokine signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-1169091: Activation of NF-kappaB in B cells
R-HSA-1280218: Adaptive Immune System
R-HSA-1236975: Antigen processing-Cross presentation
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-983169: Class I MHC mediated antigen processing & presentation
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-73887: Death Receptor Signalling
R-HSA-1643685: Disease
R-HSA-5602358: Diseases associated with the TLR signaling cascade
R-HSA-5260271: Diseases of Immune System
R-HSA-202424: Downstream TCR signaling
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-1236974: ER-Phagosome pathway
R-HSA-2871837: FCERI mediated NF-kB activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-5603027: IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
R-HSA-937041: IKK complex recruitment mediated by RIP1
R-HSA-937039: IRAK1 recruits IKK complex
R-HSA-975144: IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-5603029: IkBA variant leads to EDA-ID
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-446652: Interleukin-1 signaling
R-HSA-450294: MAP kinase activation in TLR cascade
R-HSA-5684264: MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-209560: NF-kB is activated and signals survival
R-HSA-168638: NOD1/2 Signaling Pathway
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-1810476: RIP-mediated NFkB activation via ZBP1
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-162582: Signal Transduction
R-HSA-449147: Signaling by Interleukins
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-445989: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-202403: TCR signaling
R-HSA-75893: TNF signaling
R-HSA-5357956: TNFR1-induced NFkappaB signaling pathway
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-933542: TRAF6 mediated NF-kB activation
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-1606322: ZBP1(DAI) mediated induction of type I IFNs
R-HSA-193704: p75 NTR receptor-mediated signalling
R-HSA-209543: p75NTR recruits signalling complexes
R-HSA-193639: p75NTR signals via NF-kB

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IKBKB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

[ TOP ]

Literatures describing the relation between IKBKB and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
26903482	Melanoma	Promote immunity (T cell function)	We hypothesized that forcing T cell-intrinsic NF-κB activation might break this cycle and induce tumor elimination. NF-κB was activated in T cells by inducing the expression of a constitutively active form of the upstream activator IκB kinase β (IKKβ). T cell-restricted constitutively active IKKβ augmented the frequency of functional tumor-specific CD8(+) T cells and improved tumor control.
25336190	Melanoma	Promote immunity	Myeloid IKKβ promotes antitumor immunity by modulating CCL11 and the innate immune response.

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of IKBKB in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -3.57; FDR: 0.00354	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of IKBKB in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.207	0.335
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.135	0.937
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.262	0.829
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.327	0.231
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.461	0.839
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.159	0.957
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.115	0.758
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.247	0.879
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.044	0.981
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.423	0.765
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.929	0.653
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.106	0.167

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of IKBKB in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	4.1	-0.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IKBKB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IKBKB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IKBKB. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IKBKB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IKBKB expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IKBKB and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

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Summary
Symbol	IKBKB
Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Aliases	IKK2; NFKBIKB; IKK-beta; IKKB; IMD15; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; nuclear factor NF-ka ......
Chromosomal Location	8p11.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IKBKB collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting IKBKB.

ID	Name	Drug Type	Targets	#Targets
DB00244	Mesalazine	Small Molecule	ALOX5, CHUK, IKBKB, MPO, PPARG, PTGS1, PTGS2	7
DB00795	Sulfasalazine	Small Molecule	ACAT1, ALOX5, CHUK, IKBKB, PLA2G1B, PPARG, PTGS1, PTGS2, SLC7A11, ......	10
DB00945	Acetylsalicylic acid	Small Molecule	AKR1C1, EDNRA, HSPA5, IKBKB, NFKB1, NFKB2, NFKBIA, PRKAA1, PRKAA2, ......	18
DB00995	Auranofin	Small Molecule	IKBKB, PRDX5	2
DB01169	Arsenic trioxide	Small Molecule	AKT1, CCND1, CDKN1A, HDAC1, IKBKB, JUN, MAPK1, MAPK3, PML, TXNRD1	10
DB05183	MLN0415	Small Molecule	IKBKB	1
DB06151	Acetylcysteine	Small Molecule	ACY1, CHUK, GRIN1, GRIN2A, GRIN2B, GRIN2D, GRIN3A, GSS, IKBKB, SLC ......	10
DB06521	Ertiprotafib	Small Molecule	IKBKB, PPARA, PPARG, PTPN1	4

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