Browse IL1B

Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Lysosome Secreted, exosome Secreted Note=The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence and the pathway(s) of its secretion is(are) not yet fully understood (PubMed:24201029). On the basis of experimental results, several unconventional secretion mechanisms have been proposed. 1. Secretion via secretory lysosomes: a fraction of CASP1 and IL1B precursor may be incorporated, by a yet undefined mechanism, into secretory lysosomes that undergo Ca(2+)-dependent exocytosis with release of mature IL1B (PubMed:15192144). 2. Secretory autophagy: IL1B-containing autophagosomes may fuse with endosomes or multivesicular bodies (MVBs) and then merge with the plasma membrane releasing soluble IL1B or IL1B-containing exosomes (PubMed:24201029). However, autophagy impacts IL1B production at several levels and its role in secretion is still controversial. 3. Secretion via exosomes: ATP-activation of P2RX7 leads to the formation of MVBs containing exosomes with entrapped IL1B, CASP1 and other inflammasome components. These MVBs undergo exocytosis with the release of exosomes. The release of soluble IL1B occurs after the lysis of exosome membranes (By similarity). 4. Secretion by microvesicle shedding: activation of the ATP receptor P2RX7 may induce an immediate shedding of membrane-derived microvesicles containing IL1B and possibly inflammasome components. The cytokine is then released in the extracellular compartment after microvesicle lysis (PubMed:11728343). 5. Release by translocation through permeabilized plasma membrane. This may occur in cells undergoing pyroptosis due to sustained activation of the inflammasome (By similarity). These mechanisms may not be not mutually exclusive.
Domain PF00340 Interleukin-1 / 18
PF02394 Interleukin-1 propeptide
Function

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0001659 temperature homeostasis
GO:0001660 fever generation
GO:0001819 positive regulation of cytokine production
GO:0001885 endothelial cell development
GO:0001933 negative regulation of protein phosphorylation
GO:0002064 epithelial cell development
GO:0002237 response to molecule of bacterial origin
GO:0002250 adaptive immune response
GO:0002443 leukocyte mediated immunity
GO:0002449 lymphocyte mediated immunity
GO:0002456 T cell mediated immunity
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002526 acute inflammatory response
GO:0002673 regulation of acute inflammatory response
GO:0002675 positive regulation of acute inflammatory response
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0002703 regulation of leukocyte mediated immunity
GO:0002705 positive regulation of leukocyte mediated immunity
GO:0002706 regulation of lymphocyte mediated immunity
GO:0002708 positive regulation of lymphocyte mediated immunity
GO:0002709 regulation of T cell mediated immunity
GO:0002711 positive regulation of T cell mediated immunity
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002819 regulation of adaptive immune response
GO:0002821 positive regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0003012 muscle system process
GO:0003158 endothelium development
GO:0006022 aminoglycan metabolic process
GO:0006023 aminoglycan biosynthetic process
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006066 alcohol metabolic process
GO:0006469 negative regulation of protein kinase activity
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0006509 membrane protein ectodomain proteolysis
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006694 steroid biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006775 fat-soluble vitamin metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0006909 phagocytosis
GO:0006913 nucleocytoplasmic transport
GO:0006953 acute-phase response
GO:0007067 mitotic nuclear division
GO:0007088 regulation of mitotic nuclear division
GO:0007159 leukocyte cell-cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0007346 regulation of mitotic cell cycle
GO:0007565 female pregnancy
GO:0007566 embryo implantation
GO:0008202 steroid metabolic process
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009110 vitamin biosynthetic process
GO:0009306 protein secretion
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009914 hormone transport
GO:0010573 vascular endothelial growth factor production
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010623 programmed cell death involved in cell development
GO:0010817 regulation of hormone levels
GO:0010827 regulation of glucose transport
GO:0010829 negative regulation of glucose transport
GO:0010876 lipid localization
GO:0010893 positive regulation of steroid biosynthetic process
GO:0014074 response to purine-containing compound
GO:0014805 smooth muscle adaptation
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015732 prostaglandin transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015833 peptide transport
GO:0015908 fatty acid transport
GO:0016042 lipid catabolic process
GO:0016570 histone modification
GO:0016572 histone phosphorylation
GO:0016573 histone acetylation
GO:0017038 protein import
GO:0018205 peptidyl-lysine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0019915 lipid storage
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030100 regulation of endocytosis
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030213 hyaluronan biosynthetic process
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0030656 regulation of vitamin metabolic process
GO:0030730 sequestering of triglyceride
GO:0030856 regulation of epithelial cell differentiation
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031349 positive regulation of defense response
GO:0031503 protein complex localization
GO:0031620 regulation of fever generation
GO:0031622 positive regulation of fever generation
GO:0031649 heat generation
GO:0031650 regulation of heat generation
GO:0031652 positive regulation of heat generation
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032303 regulation of icosanoid secretion
GO:0032305 positive regulation of icosanoid secretion
GO:0032306 regulation of prostaglandin secretion
GO:0032308 positive regulation of prostaglandin secretion
GO:0032309 icosanoid secretion
GO:0032310 prostaglandin secretion
GO:0032368 regulation of lipid transport
GO:0032370 positive regulation of lipid transport
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032496 response to lipopolysaccharide
GO:0032602 chemokine production
GO:0032604 granulocyte macrophage colony-stimulating factor production
GO:0032609 interferon-gamma production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032623 interleukin-2 production
GO:0032635 interleukin-6 production
GO:0032637 interleukin-8 production
GO:0032642 regulation of chemokine production
GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
GO:0032649 regulation of interferon-gamma production
GO:0032663 regulation of interleukin-2 production
GO:0032675 regulation of interleukin-6 production
GO:0032677 regulation of interleukin-8 production
GO:0032722 positive regulation of chemokine production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032757 positive regulation of interleukin-8 production
GO:0032768 regulation of monooxygenase activity
GO:0032770 positive regulation of monooxygenase activity
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033127 regulation of histone phosphorylation
GO:0033129 positive regulation of histone phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033198 response to ATP
GO:0033619 membrane protein proteolysis
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0034113 heterotypic cell-cell adhesion
GO:0034114 regulation of heterotypic cell-cell adhesion
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0034504 protein localization to nucleus
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035234 ectopic germ cell programmed cell death
GO:0035504 regulation of myosin light chain kinase activity
GO:0035505 positive regulation of myosin light chain kinase activity
GO:0035690 cellular response to drug
GO:0038034 signal transduction in absence of ligand
GO:0042033 chemokine biosynthetic process
GO:0042035 regulation of cytokine biosynthetic process
GO:0042089 cytokine biosynthetic process
GO:0042094 interleukin-2 biosynthetic process
GO:0042098 T cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0042107 cytokine metabolic process
GO:0042108 positive regulation of cytokine biosynthetic process
GO:0042110 T cell activation
GO:0042129 regulation of T cell proliferation
GO:0042176 regulation of protein catabolic process
GO:0042226 interleukin-6 biosynthetic process
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042346 positive regulation of NF-kappaB import into nucleus
GO:0042348 NF-kappaB import into nucleus
GO:0042359 vitamin D metabolic process
GO:0042362 fat-soluble vitamin biosynthetic process
GO:0042368 vitamin D biosynthetic process
GO:0042493 response to drug
GO:0042886 amide transport
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043270 positive regulation of ion transport
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043500 muscle adaptation
GO:0043543 protein acylation
GO:0044057 regulation of system process
GO:0044060 regulation of endocrine process
GO:0044070 regulation of anion transport
GO:0044283 small molecule biosynthetic process
GO:0044706 multi-multicellular organism process
GO:0044744 protein targeting to nucleus
GO:0045073 regulation of chemokine biosynthetic process
GO:0045076 regulation of interleukin-2 biosynthetic process
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045408 regulation of interleukin-6 biosynthetic process
GO:0045410 positive regulation of interleukin-6 biosynthetic process
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045446 endothelial cell differentiation
GO:0045601 regulation of endothelial cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0045785 positive regulation of cell adhesion
GO:0045787 positive regulation of cell cycle
GO:0045807 positive regulation of endocytosis
GO:0045833 negative regulation of lipid metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045840 positive regulation of mitotic nuclear division
GO:0045860 positive regulation of protein kinase activity
GO:0045862 positive regulation of proteolysis
GO:0045931 positive regulation of mitotic cell cycle
GO:0045940 positive regulation of steroid metabolic process
GO:0046136 positive regulation of vitamin metabolic process
GO:0046165 alcohol biosynthetic process
GO:0046209 nitric oxide metabolic process
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046651 lymphocyte proliferation
GO:0046683 response to organophosphorus
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0046827 positive regulation of protein export from nucleus
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0046942 carboxylic acid transport
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048871 multicellular organismal homeostasis
GO:0050663 cytokine secretion
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050755 chemokine metabolic process
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050796 regulation of insulin secretion
GO:0050810 regulation of steroid biosynthetic process
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050886 endocrine process
GO:0050900 leukocyte migration
GO:0050994 regulation of lipid catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0050996 positive regulation of lipid catabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051043 regulation of membrane protein ectodomain proteolysis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
GO:0051047 positive regulation of secretion
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051224 negative regulation of protein transport
GO:0051235 maintenance of location
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051302 regulation of cell division
GO:0051341 regulation of oxidoreductase activity
GO:0051348 negative regulation of transferase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051403 stress-activated MAPK cascade
GO:0051781 positive regulation of cell division
GO:0051783 regulation of nuclear division
GO:0051785 positive regulation of nuclear division
GO:0060326 cell chemotaxis
GO:0060352 cell adhesion molecule production
GO:0060353 regulation of cell adhesion molecule production
GO:0060355 positive regulation of cell adhesion molecule production
GO:0060556 regulation of vitamin D biosynthetic process
GO:0060557 positive regulation of vitamin D biosynthetic process
GO:0060558 regulation of calcidiol 1-monooxygenase activity
GO:0060559 positive regulation of calcidiol 1-monooxygenase activity
GO:0060627 regulation of vesicle-mediated transport
GO:0060986 endocrine hormone secretion
GO:0061028 establishment of endothelial barrier
GO:0070162 adiponectin secretion
GO:0070163 regulation of adiponectin secretion
GO:0070164 negative regulation of adiponectin secretion
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0070486 leukocyte aggregation
GO:0070487 monocyte aggregation
GO:0070489 T cell aggregation
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071214 cellular response to abiotic stimulus
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0071605 monocyte chemotactic protein-1 production
GO:0071621 granulocyte chemotaxis
GO:0071637 regulation of monocyte chemotactic protein-1 production
GO:0071639 positive regulation of monocyte chemotactic protein-1 production
GO:0071715 icosanoid transport
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072593 reactive oxygen species metabolic process
GO:0072604 interleukin-6 secretion
GO:0090068 positive regulation of cell cycle process
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090316 positive regulation of intracellular protein transport
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1901099 negative regulation of signal transduction in absence of ligand
GO:1901342 regulation of vasculature development
GO:1901550 regulation of endothelial cell development
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1902930 regulation of alcohol biosynthetic process
GO:1902932 positive regulation of alcohol biosynthetic process
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903140 regulation of establishment of endothelial barrier
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903510 mucopolysaccharide metabolic process
GO:1903531 negative regulation of secretion by cell
GO:1903532 positive regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903793 positive regulation of anion transport
GO:1903829 positive regulation of cellular protein localization
GO:1904018 positive regulation of vasculature development
GO:1904407 positive regulation of nitric oxide metabolic process
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:1905269 positive regulation of chromatin organization
GO:1990266 neutrophil migration
GO:2000191 regulation of fatty acid transport
GO:2000193 positive regulation of fatty acid transport
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2000778 positive regulation of interleukin-6 secretion
GO:2001057 reactive nitrogen species metabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005149 interleukin-1 receptor binding
GO:0070851 growth factor receptor binding
Cellular Component GO:0005776 autophagosome
GO:0030141 secretory granule
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04064 NF-kappa B signaling pathway
hsa04380 Osteoclast differentiation
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04623 Cytosolic DNA-sensing pathway
hsa04640 Hematopoietic cell lineage
hsa04668 TNF signaling pathway
hsa04750 Inflammatory mediator regulation of TRP channels
Reactome R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-5660668: CLEC7A/inflammasome pathway
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-448706: Interleukin-1 processing
R-HSA-446652: Interleukin-1 signaling
R-HSA-6783783: Interleukin-10 signaling
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IL1B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IL1B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25542861MelanomaPromote immunity (infiltration)In P2X7R-deficient mice, tumor growth and metastatic spreading were accelerated strongly, compared with wild-type (wt) mice. Intratumoral IL-1β and VEGF release were drastically reduced, and inflammatory cell infiltration was abrogated nearly completely.
22710190Gastric CarcinomaPromote immunity (T cell function)CD8(+) T cells that produce interleukin (IL)-17 (Tc17 cells) promote inflammation and have been identified in tumors. Tumor-activated monocytes secreted IL-6, IL-1β, and IL-23, which promoted development of Tc17 cell populations.
24525743Hepatocellular carcinomaInhibit immunity (T cell function)Conversely, IL-17A could also enhance production of IL-1β and IL-23 in MDSC as a positive feedback
18412246FibrosarcomaPromote immunityOpposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction. On the other hand, IL-1 beta-competent, IL-1 alpha(-/-) tumors strongly assist CD11b(+)Gr-1(+) myeloid-derived suppressor cell and regulatory T cell expansion, which both suppress with high efficacy activated T helper cell proliferation and CTL lysis. Induction of a strong immune response by IL-1 alpha demands therapeutic exploitation, which may become more efficient if systemic induction of immunosuppression by IL-1 beta can also be circumvented.
27407095Cervical carcinomaPromote immunityIntravaginal treatment of IL7-Fc, but not native IL7, induces upregulation of chemokines (CXCL10, CCL3, CCL4, and CCL5), cytokines (IFNγ, TNFα, IL6, and IL1β), and an adhesion molecule (VCAM-1) in the genital tract, leading to the recruitment of several leukocytes, including CD4, CD8, γδ T cells, and dendritic cells.
21178005Choriocarcinoma; Breast Carcinoma; Ovarian CarcinomaInhibit immunityTumor-associated a2 vacuolar ATPase acts as a key mediator of cancer-related inflammation by inducing pro-tumorigenic properties in monocytes. These included IL-1β and IL-10, which are important in promoting inflammation and immune escape by tumor cells.
20099279MelanomaInhibit immunity (T cell function)Interleukins 1alpha and 1beta secreted by some melanoma cell lines strongly reduce expression of MITF-M and melanocyte differentiation antigens. Accordingly, treating some melanoma cells with IL-1beta reduced by 40-100% their ability to activate such antimelanoma cytolytic T lymphocytes. These results indicate that the repression of melanocyte-differentiation genes by IL-1 produced by stromal cells or by tumor cells themselves may represent an additional mechanism of melanoma immune escape.
22850568MelanomaInhibit immunityTreatment of melanoma-patient-derived TAFs with IL-1α/β significantly enhanced their ability to suppress the proliferation and function of melanoma-specific cytotoxic T cells, and this inhibition was partially attributable to upregulation by IL-1 of COX-2 and the PD-1 ligands PD-L1 and PD-L2 in TAFs.
20513002Colon CarcinomaInhibit immunityColon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice. ManR expression and endocytosis increased in tumor-activated LSECs through a two-step mechanism: (1) Release of COX-2-dependent IL-1-stimulating factors by lymphocyte function-associated antigen-1-expressing C26 cells in response to intercellular adhesion molecule-1 (ICAM-1), which was expressed and secreted by tumor-activated LSECs; and (2) widespread up-regulation of ManR in LSECs through tumor-induced IL-1.
25205103lymphomaPromote immunityRecombinant HMGN1 induced the accumulation and activation of DCs at the site of injection as indicated by upregulation of costimulatory and MHC molecules as well as extracellular secretion of proinflammatory cytokines such as TNFa, IL12 p70, and IL1b
25205101melanomaPromote immunityHere, we report that ATP-mediated suppression of IFNgamma production by Th17 cells can be overcome by genetic ablation of CD73 or by using IL1beta instead of TGFbeta to program Th17 cells ex vivo. Th17 cells cultured in IL1beta were also highly polyfunctional, expressing high levels of effector molecules and exhibiting superior short-term control of melanoma in mice, despite reduced stem cell-like properties
23319306Breast Carcinoma; MelanomaPromote immunityUpon reaching the bronchoalveolar space, aerosolized CpG-ODN activated a local immune response, as indicated by production of IL-12p40, IFN-gamma and IL-1beta and by recruitment and maturation of DC cells in bronchoalveolar lavage fluid of mice.
21969559MelanomaInhibit immunityIndeed, upon manipulation of the melanoma microenvironment with the phosphodiesterase-5 inhibitor sildenafil, we observed reduced levels of numerous inflammatory mediators (e.g., IL-1β, IL-6, VEGF, S100A9) in association with decreased MDSC amounts and immunosuppressive function, indicating an antiinflammatory effect of sildenafil
21852386Breast CarcinomaInhibit immunityTaken together, our results show a dialogue between NK and tumor cells leading to IFN-γ secretion, which in turn associates with monocyte-derived IL-1β and TNF-α to drive production of CCL22 by tumor cells and subsequent recruitment of T(reg) to evade this early antitumor immune response.
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IL1B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IL1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7580.21
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.9070.524
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.6340.509
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4460.522
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.1020.129
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.6610.41
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1930.78
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2260.842
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.3380.76
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5420.571
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0090.457
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1770.47
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IL1B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IL1B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IL1B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIL1B
Nameinterleukin 1, beta
Aliases IL1F2; IL-1B; IL1-BETA; IL-1; IL-1 beta; catabolin; preinterleukin 1 beta; pro-interleukin-1-beta; Interleuk ......
Chromosomal Location2q14
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IL1B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting IL1B.
ID Name Drug Type Targets #Targets
DB01017MinocyclineSmall MoleculeALOX5, CASP1, CASP3, CYCS, IL1B, MMP9, VEGFA7
DB05133VP025Small MoleculeIL1B1
DB05260Gallium nitrateSmall MoleculeATP6V1B2, BGLAP, IL1B, RRM24
DB05412TalmapimodSmall MoleculeIL1B, MAPK14, MT-CO2, TNF4
DB05442Etiprednol dicloacetateSmall MoleculeIL1B1
DB05470VX-702Small MoleculeIL1B, IL6, MAPK14, TNF4
DB05507VX-765Small MoleculeCASP1, IL1B2
DB05767AndrographolideSmall MoleculeIL1B, IL6, NFKB1, NFKB2, TNF5
DB06168CanakinumabBiotechIL1B1
DB06372RilonaceptBiotechIL1A, IL1B, IL1RN3
DB11967BinimetinibSmall MoleculeIL1B, IL6, TNF3
DB12119GevokizumabBiotechIL1B1
DB12140DilmapimodSmall MoleculeIL1B, IL6, TNF3