TISIDB

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Single-pass type I membrane protein Cell membrane Secreted
Domain	PF07679 Immunoglobulin I-set domain PF13895 Immunoglobulin domain PF01582 TIR domain
Function	Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

> Gene Ontology [ TOP ]
Biological Process	GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001961 positive regulation of cytokine-mediated signaling pathway GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002691 regulation of cellular extravasation GO:0002693 positive regulation of cellular extravasation GO:0030335 positive regulation of cell migration GO:0040017 positive regulation of locomotion GO:0045123 cellular extravasation GO:0050727 regulation of inflammatory response GO:0050900 leukocyte migration GO:0051272 positive regulation of cellular component movement GO:0060759 regulation of response to cytokine stimulus GO:0060760 positive regulation of response to cytokine stimulus GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0071347 cellular response to interleukin-1 GO:0072672 neutrophil extravasation GO:0097529 myeloid leukocyte migration GO:0097530 granulocyte migration GO:1902622 regulation of neutrophil migration GO:1902624 positive regulation of neutrophil migration GO:1990266 neutrophil migration GO:2000147 positive regulation of cell motility GO:2000389 regulation of neutrophil extravasation GO:2000391 positive regulation of neutrophil extravasation GO:2000659 regulation of interleukin-1-mediated signaling pathway GO:2000661 positive regulation of interleukin-1-mediated signaling pathway
Molecular Function	GO:0002020 protease binding GO:0004896 cytokine receptor activity GO:0004908 interleukin-1 receptor activity GO:0004909 interleukin-1, Type I, activating receptor activity GO:0005161 platelet-derived growth factor receptor binding GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019966 interleukin-1 binding GO:0070851 growth factor receptor binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04060 Cytokine-cytokine receptor interaction hsa04064 NF-kappa B signaling pathway hsa04380 Osteoclast differentiation hsa04640 Hematopoietic cell lineage hsa04750 Inflammatory mediator regulation of TRP channels
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-446652: Interleukin-1 signaling R-HSA-6783783: Interleukin-10 signaling R-HSA-449147: Signaling by Interleukins

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IL1R1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between IL1R1 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
17942936	Breast Carcinoma	Inhibit immunity (T cell function)	We have tested this hypothesis using the 4T1 mammary carcinoma and IL-1 receptor (IL-1R)-deficient mice which have a reduced potential for inflammation, and IL-1R antagonist-deficient mice, which have an increased potential for inflammation. Consistent with our hypothesis, IL-1R-deficient mice have a delayed accumulation of MDSC and reduced primary and metastatic tumor progression.

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of IL1R1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of IL1R1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.688	0.136
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-1.588	0.339
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.009	0.992
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.437	0.359
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.908	0.641
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.159	0.949
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.221	0.722
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.084	0.96
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.491	0.805
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.699	0.631
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	2.048	0.318
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.267	0.0475

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of IL1R1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	5.5	-5.5	0.572
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	6.8	-6.8	0.304
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	9.5	17.6	-8.1	0.64
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	15.4	27.3	-11.9	0.63
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	2.6	3.7	-1.1	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1R1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1R1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1R1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1R1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IL1R1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IL1R1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	IL1R1
Name	interleukin 1 receptor, type I
Aliases	D2S1473; CD121A; IL1R; IL-1R-alpha; CD121 antigen-like family member A; IL-1R-1; IL-1RT-1; IL-1RT1; interleu ......
Chromosomal Location	2q12
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IL1R1 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting IL1R1.

ID	Name	Drug Type	Targets	#Targets
DB00026	Anakinra	Biotech	IL1R1	1
DB05207	SD118	Small Molecule	IL1R1, TNF	2
DB05303	OMS-103HP	Small Molecule	IL1R1, TNF	2

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