Browse IL1R2

Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform Short: Secreted ; SUBCELLULAR LOCATION: Isoform Long: Cell membrane; Single-pass type I membrane protein.
Domain PF00047 Immunoglobulin domain
Function

Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002534 cytokine production involved in inflammatory response
GO:0009306 protein secretion
GO:0010955 negative regulation of protein processing
GO:0016485 protein processing
GO:0031348 negative regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0032610 interleukin-1 alpha production
GO:0032612 interleukin-1 production
GO:0032650 regulation of interleukin-1 alpha production
GO:0032652 regulation of interleukin-1 production
GO:0032690 negative regulation of interleukin-1 alpha production
GO:0032692 negative regulation of interleukin-1 production
GO:0045861 negative regulation of proteolysis
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050703 interleukin-1 alpha secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050705 regulation of interleukin-1 alpha secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050711 negative regulation of interleukin-1 secretion
GO:0050712 negative regulation of interleukin-1 alpha secretion
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051224 negative regulation of protein transport
GO:0051604 protein maturation
GO:0060759 regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0070498 interleukin-1-mediated signaling pathway
GO:0070555 response to interleukin-1
GO:0070613 regulation of protein processing
GO:0071347 cellular response to interleukin-1
GO:1900015 regulation of cytokine production involved in inflammatory response
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:1903317 regulation of protein maturation
GO:1903318 negative regulation of protein maturation
GO:1903531 negative regulation of secretion by cell
GO:1904950 negative regulation of establishment of protein localization
GO:2000659 regulation of interleukin-1-mediated signaling pathway
GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
Molecular Function GO:0004896 cytokine receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0004910 interleukin-1, Type II, blocking receptor activity
GO:0019838 growth factor binding
GO:0019955 cytokine binding
GO:0019966 interleukin-1 binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04060 Cytokine-cytokine receptor interaction
hsa04640 Hematopoietic cell lineage
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-446652: Interleukin-1 signaling
R-HSA-6783783: Interleukin-10 signaling
R-HSA-449147: Signaling by Interleukins
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IL1R2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between IL1R2 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27851914Colorectal Carcinoma; small cell lung cancinomaPromote immunity (T cell function)Transcriptomes of T helper 1 (Th1), Th17, and Treg cells infiltrating colorectal or non-small-cell lung cancers were compared to transcriptomes of the same subsets from normal tissues and validated at the single-cell level. We found that tumor-infiltrating Treg cells were highly suppressive, upregulated several immune-checkpoints, and expressed on the cell surfaces specific signature molecules such as interleukin-1 receptor 2 (IL1R2), programmed death (PD)-1 Ligand1, PD-1 Ligand2, and CCR8 chemokine, which were not previously described on Treg cells.
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IL1R2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IL1R2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3770.492
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5970.553
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.1040.134
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.7680.0455
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-2.460.0898
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.890.62
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1670.76
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2720.746
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.640.475
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 483.6230.00823
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 285.0720.0142
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.4240.0659
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IL1R2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1R2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1R2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1R2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1R2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IL1R2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IL1R2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIL1R2
Nameinterleukin 1 receptor, type II
Aliases CD121b; IL1RB; CDw121b; IL-1R-2; IL-1RT-2; IL-1RT2c; CD121 antigen-like family member B; IL-1 type II recept ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IL1R2 collected from DrugBank database.
> Drugs from DrugBank database
 

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