Browse IL1RL1

Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform C: Cell membrane.; SUBCELLULAR LOCATION: Isoform B: Secreted.; SUBCELLULAR LOCATION: Cell membrane Single-pass type I membrane protein
Domain PF07679 Immunoglobulin I-set domain
PF01582 TIR domain
Function

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. ; FUNCTION: Isoform B: Inhibits IL-33 signaling.

> Gene Ontology
 
Biological Process GO:0001818 negative regulation of cytokine production
GO:0001819 positive regulation of cytokine production
GO:0002250 adaptive immune response
GO:0002274 myeloid leukocyte activation
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002819 regulation of adaptive immune response
GO:0002820 negative regulation of adaptive immune response
GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002825 regulation of T-helper 1 type immune response
GO:0002826 negative regulation of T-helper 1 type immune response
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009306 protein secretion
GO:0031349 positive regulation of defense response
GO:0032103 positive regulation of response to external stimulus
GO:0032602 chemokine production
GO:0032609 interferon-gamma production
GO:0032634 interleukin-5 production
GO:0032642 regulation of chemokine production
GO:0032649 regulation of interferon-gamma production
GO:0032674 regulation of interleukin-5 production
GO:0032689 negative regulation of interferon-gamma production
GO:0032722 positive regulation of chemokine production
GO:0032754 positive regulation of interleukin-5 production
GO:0038172 interleukin-33-mediated signaling pathway
GO:0042088 T-helper 1 type immune response
GO:0042116 macrophage activation
GO:0043030 regulation of macrophage activation
GO:0043032 positive regulation of macrophage activation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0051047 positive regulation of secretion
GO:0051222 positive regulation of protein transport
GO:0090195 chemokine secretion
GO:0090196 regulation of chemokine secretion
GO:0090197 positive regulation of chemokine secretion
GO:1902532 negative regulation of intracellular signal transduction
GO:1903532 positive regulation of secretion by cell
GO:1904951 positive regulation of establishment of protein localization
Molecular Function GO:0002113 interleukin-33 binding
GO:0002114 interleukin-33 receptor activity
GO:0004896 cytokine receptor activity
GO:0004908 interleukin-1 receptor activity
GO:0005057 receptor signaling protein activity
GO:0019955 cytokine binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0009897 external side of plasma membrane
GO:0098552 side of membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-449147: Signaling by Interleukins
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IL1RL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IL1RL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IL1RL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2820.655
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0920.538
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7330.716
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.5940.388
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.3920.743
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.1950.249
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4290.643
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6960.563
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9245.24e-05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IL1RL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.75.5-1.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.75.1-1.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.35.98.40.613
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1RL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1RL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1RL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1RL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IL1RL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IL1RL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIL1RL1
Nameinterleukin 1 receptor-like 1
Aliases FIT-1; ST2V; DER4; IL33R; homolog of mouse growth stimulation-expressed; growth stimulation-expressed; inter ......
Chromosomal Location2q12
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IL1RL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.