Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane Single-pass type I membrane protein ; SUBCELLULAR LOCATION: Isoform 2: Secreted |
Domain |
PF00041 Fibronectin type III domain PF09240 Interleukin-6 receptor alpha chain PF06328 Ig-like C2-type domain |
Function |
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity). |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0001819 positive regulation of cytokine production GO:0002250 adaptive immune response GO:0002526 acute inflammatory response GO:0002673 regulation of acute inflammatory response GO:0002675 positive regulation of acute inflammatory response GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0002819 regulation of adaptive immune response GO:0002821 positive regulation of adaptive immune response GO:0003012 muscle system process GO:0003300 cardiac muscle hypertrophy GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006112 energy reserve metabolic process GO:0007159 leukocyte cell-cell adhesion GO:0007219 Notch signaling pathway GO:0007259 JAK-STAT cascade GO:0007260 tyrosine phosphorylation of STAT protein GO:0008593 regulation of Notch signaling pathway GO:0010001 glial cell differentiation GO:0010573 vascular endothelial growth factor production GO:0010574 regulation of vascular endothelial growth factor production GO:0010575 positive regulation of vascular endothelial growth factor production GO:0010611 regulation of cardiac muscle hypertrophy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0010720 positive regulation of cell development GO:0014013 regulation of gliogenesis GO:0014015 positive regulation of gliogenesis GO:0014742 positive regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0015980 energy derivation by oxidation of organic compounds GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0030278 regulation of ossification GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0032946 positive regulation of mononuclear cell proliferation GO:0038154 interleukin-11-mediated signaling pathway GO:0038165 oncostatin-M-mediated signaling pathway GO:0042063 gliogenesis GO:0042098 T cell proliferation GO:0042102 positive regulation of T cell proliferation GO:0042110 T cell activation GO:0042129 regulation of T cell proliferation GO:0042503 tyrosine phosphorylation of Stat3 protein GO:0042508 tyrosine phosphorylation of Stat1 protein GO:0042509 regulation of tyrosine phosphorylation of STAT protein GO:0042510 regulation of tyrosine phosphorylation of Stat1 protein GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0044042 glucan metabolic process GO:0044057 regulation of system process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044723 single-organism carbohydrate metabolic process GO:0045667 regulation of osteoblast differentiation GO:0045669 positive regulation of osteoblast differentiation GO:0045685 regulation of glial cell differentiation GO:0045687 positive regulation of glial cell differentiation GO:0045778 positive regulation of ossification GO:0045785 positive regulation of cell adhesion GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046651 lymphocyte proliferation GO:0048708 astrocyte differentiation GO:0048710 regulation of astrocyte differentiation GO:0048711 positive regulation of astrocyte differentiation GO:0048861 leukemia inhibitory factor signaling pathway GO:0050670 regulation of lymphocyte proliferation GO:0050671 positive regulation of lymphocyte proliferation GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051962 positive regulation of nervous system development GO:0070102 interleukin-6-mediated signaling pathway GO:0070106 interleukin-27-mediated signaling pathway GO:0070120 ciliary neurotrophic factor-mediated signaling pathway GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0070665 positive regulation of leukocyte proliferation GO:0070741 response to interleukin-6 GO:0071354 cellular response to interleukin-6 GO:0071593 lymphocyte aggregation GO:0090257 regulation of muscle system process GO:0097696 STAT cascade GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade |
Molecular Function |
GO:0004896 cytokine receptor activity GO:0004897 ciliary neurotrophic factor receptor activity GO:0004915 interleukin-6 receptor activity GO:0004921 interleukin-11 receptor activity GO:0004923 leukemia inhibitory factor receptor activity GO:0004924 oncostatin-M receptor activity GO:0005126 cytokine receptor binding GO:0005127 ciliary neurotrophic factor receptor binding GO:0005138 interleukin-6 receptor binding GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019970 interleukin-11 binding GO:0019981 interleukin-6 binding GO:0030368 interleukin-17 receptor activity GO:0045509 interleukin-27 receptor activity GO:0070851 growth factor receptor binding |
Cellular Component |
GO:0005896 interleukin-6 receptor complex GO:0005900 oncostatin-M receptor complex GO:0009897 external side of plasma membrane GO:0030425 dendrite GO:0043025 neuronal cell body GO:0043235 receptor complex GO:0044297 cell body GO:0070110 ciliary neurotrophic factor receptor complex GO:0098552 side of membrane GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04060 Cytokine-cytokine receptor interaction hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04630 Jak-STAT signaling pathway |
Reactome |
R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-6788467: IL-6-type cytokine receptor ligand interactions R-HSA-168256: Immune System R-HSA-6783589: Interleukin-6 family signaling R-HSA-1059683: Interleukin-6 signaling R-HSA-5683057: MAPK family signaling cascades R-HSA-112411: MAPK1 (ERK2) activation R-HSA-5684996: MAPK1/MAPK3 signaling R-HSA-110056: MAPK3 (ERK1) activation R-HSA-112409: RAF-independent MAPK1/3 activation R-HSA-162582: Signal Transduction R-HSA-449147: Signaling by Interleukins |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between IL6ST and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between IL6ST and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of IL6ST in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of IL6ST in various data sets.
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Points in the above scatter plot represent the mutation difference of IL6ST in various data sets.
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Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL6ST. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL6ST. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL6ST. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL6ST. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of IL6ST expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between IL6ST and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | IL6ST |
Name | interleukin 6 signal transducer |
Aliases | CD130; gp130, oncostatin M receptor; interleukin 6 signal transducer (gp130, oncostatin M receptor); CDW130; ...... |
Chromosomal Location | 5q11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting IL6ST collected from DrugBank database. |
There is no record. |