TISIDB

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytosol Endoplasmic reticulum-Golgi intermediate compartment Early endosome membrane Membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle, phagosome membrane Golgi apparatus
Domain	PF03372 Endonuclease/Exonuclease/phosphatase family PF16776 Type II inositol 1 PF00620 RhoGAP domain
Function	Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.

> Gene Ontology [ TOP ]
Biological Process	GO:0001701 in utero embryonic development GO:0006066 alcohol metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0007283 spermatogenesis GO:0016311 dephosphorylation GO:0016485 protein processing GO:0019751 polyol metabolic process GO:0030258 lipid modification GO:0030317 flagellated sperm motility GO:0043647 inositol phosphate metabolic process GO:0046486 glycerolipid metabolic process GO:0046488 phosphatidylinositol metabolic process GO:0046839 phospholipid dephosphorylation GO:0046856 phosphatidylinositol dephosphorylation GO:0048232 male gamete generation GO:0051056 regulation of small GTPase mediated signal transduction GO:0051604 protein maturation GO:0070613 regulation of protein processing GO:0097722 sperm motility GO:1901615 organic hydroxy compound metabolic process GO:1903317 regulation of protein maturation
Molecular Function	GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0016791 phosphatase activity GO:0030695 GTPase regulator activity GO:0034593 phosphatidylinositol bisphosphate phosphatase activity GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0046030 inositol trisphosphate phosphatase activity GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity GO:0052743 inositol tetrakisphosphate phosphatase activity GO:0052745 inositol phosphate phosphatase activity GO:0052866 phosphatidylinositol phosphate phosphatase activity GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component	GO:0005769 early endosome GO:0005793 endoplasmic reticulum-Golgi intermediate compartment GO:0010008 endosome membrane GO:0030139 endocytic vesicle GO:0030659 cytoplasmic vesicle membrane GO:0030666 endocytic vesicle membrane GO:0030670 phagocytic vesicle membrane GO:0031901 early endosome membrane GO:0044440 endosomal part GO:0045335 phagocytic vesicle

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04070 Phosphatidylinositol signaling system hsa00562 Inositol phosphate metabolism hsa01100 Metabolic pathways
Reactome	R-HSA-1483249: Inositol phosphate metabolism R-HSA-1430728: Metabolism R-HSA-194840: Rho GTPase cycle R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-1855183: Synthesis of IP2, IP, and Ins in the cytosol R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between INPP5B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of INPP5B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	Total # shRNA with >= 4-fold: 1	Resistant to T-cell proliferation
24476824	shRNA	melanoma	B16	Secondary screen	Total # shRNA with >= 4-fold: 5	Resistant to T-cell proliferation

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of INPP5B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.221	0.301
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.2	0.871
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.238	0.794
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.005	0.985
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.153	0.934
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.184	0.939
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.097	0.737
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.226	0.866
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.025	0.987
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.218	0.812
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.17	0.894
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.001	0.984

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of INPP5B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	14.3	0	14.3	0.196
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	25	0	25	0.222
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	0	7.4	0.0709
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	0	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	11.8	-7	0.577
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	12.5	33.3	-20.8	0.538
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INPP5B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INPP5B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INPP5B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INPP5B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of INPP5B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between INPP5B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	INPP5B
Name	inositol polyphosphate-5-phosphatase B
Aliases	inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location	1p34
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting INPP5B collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting INPP5B.

ID	Name	Drug Type	Targets	#Targets
DB03158	D-Myo-Inositol-1,4-Bisphosphate	Small Molecule	INPP5B	1

Browse INPP5B