Browse INPP5K

Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum Note=Following stimulation with EGF, translocates to membrane ruffles.
Domain PF03372 Endonuclease/Exonuclease/phosphatase family
Function

Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (PubMed:10753883). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity).

> Gene Ontology
 
Biological Process GO:0000271 polysaccharide biosynthetic process
GO:0001701 in utero embryonic development
GO:0001933 negative regulation of protein phosphorylation
GO:0003014 renal system process
GO:0003091 renal water homeostasis
GO:0003097 renal water transport
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006066 alcohol metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0006469 negative regulation of protein kinase activity
GO:0006612 protein targeting to membrane
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0006661 phosphatidylinositol biosynthetic process
GO:0006816 calcium ion transport
GO:0006833 water transport
GO:0007009 plasma membrane organization
GO:0007015 actin filament organization
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0008654 phospholipid biosynthetic process
GO:0009250 glucan biosynthetic process
GO:0010639 negative regulation of organelle organization
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010677 negative regulation of cellular carbohydrate metabolic process
GO:0010799 regulation of peptidyl-threonine phosphorylation
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0010827 regulation of glucose transport
GO:0010829 negative regulation of glucose transport
GO:0010906 regulation of glucose metabolic process
GO:0010959 regulation of metal ion transport
GO:0010962 regulation of glucan biosynthetic process
GO:0014074 response to purine-containing compound
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016051 carbohydrate biosynthetic process
GO:0016311 dephosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0019318 hexose metabolic process
GO:0019751 polyol metabolic process
GO:0030031 cell projection assembly
GO:0030038 contractile actin filament bundle assembly
GO:0030104 water homeostasis
GO:0030258 lipid modification
GO:0031032 actomyosin structure organization
GO:0031529 ruffle organization
GO:0032231 regulation of actin filament bundle assembly
GO:0032232 negative regulation of actin filament bundle assembly
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032881 regulation of polysaccharide metabolic process
GO:0032885 regulation of polysaccharide biosynthetic process
GO:0032897 negative regulation of viral transcription
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033500 carbohydrate homeostasis
GO:0033673 negative regulation of kinase activity
GO:0033692 cellular polysaccharide biosynthetic process
GO:0034612 response to tumor necrosis factor
GO:0034637 cellular carbohydrate biosynthetic process
GO:0035303 regulation of dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035809 regulation of urine volume
GO:0035810 positive regulation of urine volume
GO:0035821 modification of morphology or physiology of other organism
GO:0039692 single stranded viral RNA replication via double stranded DNA intermediate
GO:0039694 viral RNA genome replication
GO:0039703 RNA replication
GO:0042044 fluid transport
GO:0042326 negative regulation of phosphorylation
GO:0042593 glucose homeostasis
GO:0043149 stress fiber assembly
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043271 negative regulation of ion transport
GO:0043405 regulation of MAP kinase activity
GO:0043407 negative regulation of MAP kinase activity
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043491 protein kinase B signaling
GO:0043647 inositol phosphate metabolic process
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0043921 modulation by host of viral transcription
GO:0043922 negative regulation by host of viral transcription
GO:0044033 multi-organism metabolic process
GO:0044042 glucan metabolic process
GO:0044057 regulation of system process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044282 small molecule catabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0045017 glycerolipid biosynthetic process
GO:0045069 regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045912 negative regulation of carbohydrate metabolic process
GO:0046164 alcohol catabolic process
GO:0046174 polyol catabolic process
GO:0046434 organophosphate catabolic process
GO:0046474 glycerophospholipid biosynthetic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0046683 response to organophosphorus
GO:0046782 regulation of viral transcription
GO:0046838 phosphorylated carbohydrate dephosphorylation
GO:0046839 phospholipid dephosphorylation
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048525 negative regulation of viral process
GO:0048871 multicellular organismal homeostasis
GO:0050792 regulation of viral process
GO:0050878 regulation of body fluid levels
GO:0050891 multicellular organismal water homeostasis
GO:0051017 actin filament bundle assembly
GO:0051051 negative regulation of transport
GO:0051052 regulation of DNA metabolic process
GO:0051053 negative regulation of DNA metabolic process
GO:0051224 negative regulation of protein transport
GO:0051348 negative regulation of transferase activity
GO:0051492 regulation of stress fiber assembly
GO:0051493 regulation of cytoskeleton organization
GO:0051494 negative regulation of cytoskeleton organization
GO:0051497 negative regulation of stress fiber assembly
GO:0051591 response to cAMP
GO:0051702 interaction with symbiont
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0051896 regulation of protein kinase B signaling
GO:0051898 negative regulation of protein kinase B signaling
GO:0051924 regulation of calcium ion transport
GO:0051926 negative regulation of calcium ion transport
GO:0052312 modulation of transcription in other organism involved in symbiotic interaction
GO:0052472 modulation by host of symbiont transcription
GO:0061572 actin filament bundle organization
GO:0070838 divalent metal ion transport
GO:0070849 response to epidermal growth factor
GO:0070873 regulation of glycogen metabolic process
GO:0070874 negative regulation of glycogen metabolic process
GO:0071320 cellular response to cAMP
GO:0071356 cellular response to tumor necrosis factor
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071545 inositol phosphate catabolic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072511 divalent inorganic cation transport
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090313 regulation of protein targeting to membrane
GO:0090315 negative regulation of protein targeting to membrane
GO:0090317 negative regulation of intracellular protein transport
GO:0097178 ruffle assembly
GO:0098801 regulation of renal system process
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1901615 organic hydroxy compound metabolic process
GO:1901616 organic hydroxy compound catabolic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1902532 negative regulation of intracellular signal transduction
GO:1903533 regulation of protein targeting
GO:1903828 negative regulation of cellular protein localization
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
GO:1904950 negative regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
GO:2000465 regulation of glycogen (starch) synthase activity
GO:2000466 negative regulation of glycogen (starch) synthase activity
GO:2001151 regulation of renal water transport
GO:2001153 positive regulation of renal water transport
Molecular Function GO:0001653 peptide receptor activity
GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0004445 inositol-polyphosphate 5-phosphatase activity
GO:0005000 vasopressin receptor activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0016312 inositol bisphosphate phosphatase activity
GO:0016791 phosphatase activity
GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity
GO:0034594 phosphatidylinositol trisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0042577 lipid phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0046030 inositol trisphosphate phosphatase activity
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052743 inositol tetrakisphosphate phosphatase activity
GO:0052745 inositol phosphate phosphatase activity
GO:0052866 phosphatidylinositol phosphate phosphatase activity
Cellular Component GO:0001726 ruffle
GO:0005802 trans-Golgi network
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0031984 organelle subcompartment
GO:0032587 ruffle membrane
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG hsa04070 Phosphatidylinositol signaling system
hsa04910 Insulin signaling pathway
hsa00562 Inositol phosphate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1430728: Metabolism
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-1483255: PI Metabolism
R-HSA-1483257: Phospholipid metabolism
R-HSA-1660499: Synthesis of PIPs at the plasma membrane
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between INPP5K and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of INPP5K in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of INPP5K in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1890.46
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1680.925
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4480.735
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.660.03
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7710.627
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5240.808
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.080.803
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4280.767
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.3620.829
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5910.688
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8080.712
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0450.482
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of INPP5K in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.703.70.27
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.703.70.314
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INPP5K. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INPP5K. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INPP5K.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INPP5K. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of INPP5K expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between INPP5K and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolINPP5K
Nameinositol polyphosphate-5-phosphatase K
Aliases skeletal muscle and kidney enriched inositol phosphatase; skeletal muscle and kidney-enriched inositol phosp ......
Chromosomal Location17p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting INPP5K collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.