TISIDB

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
Domain	PF00929 Exonuclease
Function	Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

> Gene Ontology [ TOP ]
Biological Process	GO:0000738 DNA catabolic process, exonucleolytic GO:0006308 DNA catabolic process GO:0006364 rRNA processing GO:0006401 RNA catabolic process GO:0009615 response to virus GO:0016072 rRNA metabolic process GO:0019058 viral life cycle GO:0019079 viral genome replication GO:0019439 aromatic compound catabolic process GO:0022613 ribonucleoprotein complex biogenesis GO:0034340 response to type I interferon GO:0034470 ncRNA processing GO:0034655 nucleobase-containing compound catabolic process GO:0042254 ribosome biogenesis GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism GO:0044270 cellular nitrogen compound catabolic process GO:0045069 regulation of viral genome replication GO:0045071 negative regulation of viral genome replication GO:0046700 heterocycle catabolic process GO:0048525 negative regulation of viral process GO:0050792 regulation of viral process GO:0051607 defense response to virus GO:0060337 type I interferon signaling pathway GO:0071357 cellular response to type I interferon GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0090501 RNA phosphodiester bond hydrolysis GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic GO:0098542 defense response to other organism GO:1901361 organic cyclic compound catabolic process GO:1903900 regulation of viral life cycle GO:1903901 negative regulation of viral life cycle
Molecular Function	GO:0000175 3'-5'-exoribonuclease activity GO:0004518 nuclease activity GO:0004527 exonuclease activity GO:0004529 exodeoxyribonuclease activity GO:0004532 exoribonuclease activity GO:0004536 deoxyribonuclease activity GO:0004540 ribonuclease activity GO:0008296 3'-5'-exodeoxyribonuclease activity GO:0008297 single-stranded DNA exodeoxyribonuclease activity GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity GO:0008408 3'-5' exonuclease activity GO:0008859 exoribonuclease II activity GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters GO:0017069 snRNA binding GO:0030515 snoRNA binding GO:0030619 U1 snRNA binding GO:0030620 U2 snRNA binding GO:0034511 U3 snoRNA binding
Cellular Component	GO:0015030 Cajal body GO:0016604 nuclear body GO:0016605 PML body

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-913531: Interferon Signaling R-HSA-909733: Interferon alpha/beta signaling

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ISG20 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of ISG20 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of ISG20 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.292	0.61
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	1.47	0.544
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.572	0.759
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.036	0.937
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.188	0.894
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.168	0.935
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.664	0.243
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.359	0.752
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.969	0.448
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	1.571	0.36
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.769	0.778
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.044	0.788

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ISG20 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	2.7	-2.7	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.4	-3.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	6.2	-6.2	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ISG20. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ISG20. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ISG20. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ISG20. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ISG20 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ISG20 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ISG20
Name	interferon stimulated exonuclease gene 20kDa
Aliases	HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location	15q26
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ISG20 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ISG20.

ID	Name	Drug Type	Targets	#Targets
DB03685	Uridine monophosphate	Small Molecule	B4GALT1, GLT6D1, ISG20, LSM6, UCKL1	5

Browse ISG20