Browse ISG20

Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus. Nucleus, nucleolus. Cytoplasm. Nucleus, Cajal body.
Domain PF00929 Exonuclease
Function

Interferon-induced antiviral exoribonuclease that acts on single-stranded RNA and also has minor activity towards single-stranded DNA. Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) in an exonuclease-dependent manner. May also play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis.

> Gene Ontology
 
Biological Process GO:0000738 DNA catabolic process, exonucleolytic
GO:0006308 DNA catabolic process
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0016072 rRNA metabolic process
GO:0019058 viral life cycle
GO:0019079 viral genome replication
GO:0019439 aromatic compound catabolic process
GO:0022613 ribonucleoprotein complex biogenesis
GO:0034340 response to type I interferon
GO:0034470 ncRNA processing
GO:0034655 nucleobase-containing compound catabolic process
GO:0042254 ribosome biogenesis
GO:0043900 regulation of multi-organism process
GO:0043901 negative regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044270 cellular nitrogen compound catabolic process
GO:0045069 regulation of viral genome replication
GO:0045071 negative regulation of viral genome replication
GO:0046700 heterocycle catabolic process
GO:0048525 negative regulation of viral process
GO:0050792 regulation of viral process
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0071357 cellular response to type I interferon
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:0098542 defense response to other organism
GO:1901361 organic cyclic compound catabolic process
GO:1903900 regulation of viral life cycle
GO:1903901 negative regulation of viral life cycle
Molecular Function GO:0000175 3'-5'-exoribonuclease activity
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0004529 exodeoxyribonuclease activity
GO:0004532 exoribonuclease activity
GO:0004536 deoxyribonuclease activity
GO:0004540 ribonuclease activity
GO:0008296 3'-5'-exodeoxyribonuclease activity
GO:0008297 single-stranded DNA exodeoxyribonuclease activity
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0008859 exoribonuclease II activity
GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters
GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters
GO:0017069 snRNA binding
GO:0030515 snoRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0034511 U3 snoRNA binding
Cellular Component GO:0015030 Cajal body
GO:0016604 nuclear body
GO:0016605 PML body
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-168256: Immune System
R-HSA-913531: Interferon Signaling
R-HSA-909733: Interferon alpha/beta signaling
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ISG20 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ISG20 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ISG20 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2920.61
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.470.544
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.5720.759
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0360.937
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1880.894
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1680.935
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.6640.243
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3590.752
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9690.448
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.5710.36
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7690.778
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0440.788
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ISG20 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ISG20. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ISG20. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ISG20.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ISG20. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ISG20 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ISG20 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolISG20
Nameinterferon stimulated exonuclease gene 20kDa
Aliases HEM45; interferon stimulated gene (20kD); estrogen-regulated transcript 45 protein; promyelocytic leukemia n ......
Chromosomal Location15q26
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ISG20 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ISG20.
ID Name Drug Type Targets #Targets
DB03685Uridine monophosphateSmall MoleculeB4GALT1, GLT6D1, ISG20, LSM6, UCKL15