Browse ISL1

Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00046 Homeobox domain
PF00412 LIM domain
Function

DNA-binding transcriptional activator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA-3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Cooperates with the transcription factor POU4F2 to achieve maximal levels of expression of RGC target genes and RGC fate specification in the developing retina. Involved in the specification of motor neurons in cooperation with LHX3 and LDB1. Binds to insulin gene enhancer sequences. Essential for heart development. Marker of one progenitor cell population that give rise to the outflow tract, right ventricle, a subset of left ventricular cells, and a large number of atrial cells as well, its function is required for these progenitors to contribute to the heart. Controls the expression of FGF and BMP growth factors in this cell population and is required for proliferation and survival of cells within pharyngeal foregut endoderm and adjacent splanchnic mesoderm as well as for migration of cardiac progenitors into the heart (By similarity).

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001667 ameboidal-type cell migration
GO:0001708 cell fate specification
GO:0001709 cell fate determination
GO:0001755 neural crest cell migration
GO:0001819 positive regulation of cytokine production
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0003002 regionalization
GO:0003007 heart morphogenesis
GO:0003128 heart field specification
GO:0003139 secondary heart field specification
GO:0003148 outflow tract septum morphogenesis
GO:0003151 outflow tract morphogenesis
GO:0003156 regulation of animal organ formation
GO:0003197 endocardial cushion development
GO:0003203 endocardial cushion morphogenesis
GO:0003205 cardiac chamber development
GO:0003206 cardiac chamber morphogenesis
GO:0003208 cardiac ventricle morphogenesis
GO:0003209 cardiac atrium morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003229 ventricular cardiac muscle tissue development
GO:0003230 cardiac atrium development
GO:0003231 cardiac ventricle development
GO:0003263 cardioblast proliferation
GO:0003264 regulation of cardioblast proliferation
GO:0003266 regulation of secondary heart field cardioblast proliferation
GO:0003279 cardiac septum development
GO:0003283 atrial septum development
GO:0006473 protein acetylation
GO:0006475 internal protein amino acid acetylation
GO:0007259 JAK-STAT cascade
GO:0007260 tyrosine phosphorylation of STAT protein
GO:0007389 pattern specification process
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007422 peripheral nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0009306 protein secretion
GO:0009755 hormone-mediated signaling pathway
GO:0009914 hormone transport
GO:0010002 cardioblast differentiation
GO:0010092 specification of animal organ identity
GO:0010573 vascular endothelial growth factor production
GO:0010574 regulation of vascular endothelial growth factor production
GO:0010575 positive regulation of vascular endothelial growth factor production
GO:0010721 negative regulation of cell development
GO:0010817 regulation of hormone levels
GO:0014031 mesenchymal cell development
GO:0014032 neural crest cell development
GO:0014033 neural crest cell differentiation
GO:0014706 striated muscle tissue development
GO:0015833 peptide transport
GO:0016055 Wnt signaling pathway
GO:0016570 histone modification
GO:0016573 histone acetylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018205 peptidyl-lysine modification
GO:0018212 peptidyl-tyrosine modification
GO:0018393 internal peptidyl-lysine acetylation
GO:0018394 peptidyl-lysine acetylation
GO:0021510 spinal cord development
GO:0021515 cell differentiation in spinal cord
GO:0021517 ventral spinal cord development
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021522 spinal cord motor neuron differentiation
GO:0021524 visceral motor neuron differentiation
GO:0021536 diencephalon development
GO:0021545 cranial nerve development
GO:0021559 trigeminal nerve development
GO:0021675 nerve development
GO:0021953 central nervous system neuron differentiation
GO:0021983 pituitary gland development
GO:0023061 signal release
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030518 intracellular steroid hormone receptor signaling pathway
GO:0030520 intracellular estrogen receptor signaling pathway
GO:0030522 intracellular receptor signaling pathway
GO:0030900 forebrain development
GO:0031016 pancreas development
GO:0031056 regulation of histone modification
GO:0031058 positive regulation of histone modification
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0031290 retinal ganglion cell axon guidance
GO:0031348 negative regulation of defense response
GO:0031960 response to corticosteroid
GO:0032024 positive regulation of insulin secretion
GO:0032091 negative regulation of protein binding
GO:0032102 negative regulation of response to external stimulus
GO:0032604 granulocyte macrophage colony-stimulating factor production
GO:0032609 interferon-gamma production
GO:0032610 interleukin-1 alpha production
GO:0032611 interleukin-1 beta production
GO:0032612 interleukin-1 production
GO:0032615 interleukin-12 production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032645 regulation of granulocyte macrophage colony-stimulating factor production
GO:0032649 regulation of interferon-gamma production
GO:0032650 regulation of interleukin-1 alpha production
GO:0032651 regulation of interleukin-1 beta production
GO:0032652 regulation of interleukin-1 production
GO:0032655 regulation of interleukin-12 production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032725 positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729 positive regulation of interferon-gamma production
GO:0032730 positive regulation of interleukin-1 alpha production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032732 positive regulation of interleukin-1 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0033143 regulation of intracellular steroid hormone receptor signaling pathway
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033146 regulation of intracellular estrogen receptor signaling pathway
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway
GO:0035051 cardiocyte differentiation
GO:0035065 regulation of histone acetylation
GO:0035066 positive regulation of histone acetylation
GO:0035270 endocrine system development
GO:0036301 macrophage colony-stimulating factor production
GO:0042503 tyrosine phosphorylation of Stat3 protein
GO:0042509 regulation of tyrosine phosphorylation of STAT protein
GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042692 muscle cell differentiation
GO:0042886 amide transport
GO:0043388 positive regulation of DNA binding
GO:0043393 regulation of protein binding
GO:0043401 steroid hormone mediated signaling pathway
GO:0043496 regulation of protein homodimerization activity
GO:0043523 regulation of neuron apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0043543 protein acylation
GO:0045165 cell fate commitment
GO:0045445 myoblast differentiation
GO:0045665 negative regulation of neuron differentiation
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0046425 regulation of JAK-STAT cascade
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048514 blood vessel morphogenesis
GO:0048545 response to steroid hormone
GO:0048644 muscle organ morphogenesis
GO:0048645 animal organ formation
GO:0048663 neuron fate commitment
GO:0048665 neuron fate specification
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048678 response to axon injury
GO:0048732 gland development
GO:0048738 cardiac muscle tissue development
GO:0048762 mesenchymal cell differentiation
GO:0048863 stem cell differentiation
GO:0048864 stem cell development
GO:0048880 sensory system development
GO:0048934 peripheral nervous system neuron differentiation
GO:0048935 peripheral nervous system neuron development
GO:0048936 peripheral nervous system neuron axonogenesis
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050768 negative regulation of neurogenesis
GO:0050796 regulation of insulin secretion
GO:0051047 positive regulation of secretion
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051100 negative regulation of binding
GO:0051101 regulation of DNA binding
GO:0051222 positive regulation of protein transport
GO:0051384 response to glucocorticoid
GO:0051402 neuron apoptotic process
GO:0051961 negative regulation of nervous system development
GO:0055008 cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060037 pharyngeal system development
GO:0060070 canonical Wnt signaling pathway
GO:0060379 cardiac muscle cell myoblast differentiation
GO:0060384 innervation
GO:0060411 cardiac septum morphogenesis
GO:0060413 atrial septum morphogenesis
GO:0060415 muscle tissue morphogenesis
GO:0060485 mesenchyme development
GO:0060537 muscle tissue development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0060911 cardiac cell fate commitment
GO:0060913 cardiac cell fate determination
GO:0060914 heart formation
GO:0061323 cell proliferation involved in heart morphogenesis
GO:0061564 axon development
GO:0070997 neuron death
GO:0071383 cellular response to steroid hormone stimulus
GO:0071384 cellular response to corticosteroid stimulus
GO:0071385 cellular response to glucocorticoid stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071611 granulocyte colony-stimulating factor production
GO:0071655 regulation of granulocyte colony-stimulating factor production
GO:0071657 positive regulation of granulocyte colony-stimulating factor production
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0072132 mesenchyme morphogenesis
GO:0090074 negative regulation of protein homodimerization activity
GO:0090087 regulation of peptide transport
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0097485 neuron projection guidance
GO:0097696 STAT cascade
GO:0198738 cell-cell signaling by wnt
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901256 regulation of macrophage colony-stimulating factor production
GO:1901258 positive regulation of macrophage colony-stimulating factor production
GO:1901342 regulation of vasculature development
GO:1901983 regulation of protein acetylation
GO:1901985 positive regulation of protein acetylation
GO:1902275 regulation of chromatin organization
GO:1903532 positive regulation of secretion by cell
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903557 positive regulation of tumor necrosis factor superfamily cytokine production
GO:1904018 positive regulation of vasculature development
GO:1904892 regulation of STAT cascade
GO:1904894 positive regulation of STAT cascade
GO:1904951 positive regulation of establishment of protein localization
GO:1905269 positive regulation of chromatin organization
GO:2000027 regulation of organ morphogenesis
GO:2000136 regulation of cell proliferation involved in heart morphogenesis
GO:2000756 regulation of peptidyl-lysine acetylation
GO:2000758 positive regulation of peptidyl-lysine acetylation
GO:2000826 regulation of heart morphogenesis
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001085 RNA polymerase II transcription factor binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0001104 RNA polymerase II transcription cofactor activity
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0001158 enhancer sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding
GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
GO:0016922 ligand-dependent nuclear receptor binding
GO:0030331 estrogen receptor binding
GO:0033613 activating transcription factor binding
GO:0035257 nuclear hormone receptor binding
GO:0035258 steroid hormone receptor binding
GO:0035326 enhancer binding
GO:0043425 bHLH transcription factor binding
GO:0051427 hormone receptor binding
GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04550 Signaling pathways regulating pluripotency of stem cells
Reactome R-HSA-400508: Incretin synthesis, secretion, and inactivation
R-HSA-392499: Metabolism of proteins
R-HSA-2980736: Peptide hormone metabolism
R-HSA-400511: Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ISL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ISL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ISL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3260.337
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6980.251
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0590.906
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.5350.0809
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3730.285
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.7490.234
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.9910.316
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5740.732
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.3210.432
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3710.299
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ISL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.1011.10.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.1011.10.0286
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ISL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ISL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ISL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ISL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ISL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ISL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolISL1
NameISL LIM homeobox 1
Aliases Isl-1; ISLET1; ISL1 transcription factor, LIM/homeodomain, (islet-1); ISL1 transcription factor, LIM/homeodo ......
Chromosomal Location5q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ISL1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.