Summary | |
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Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF01839 FG-GAP repeat PF08441 Integrin alpha PF00092 von Willebrand factor type A domain |
Function |
Integrin alpha-11/beta-1 is a receptor for collagen. |
Biological Process |
GO:0001503 ossification GO:0001649 osteoblast differentiation GO:0006929 substrate-dependent cell migration GO:0007160 cell-matrix adhesion GO:0007229 integrin-mediated signaling pathway GO:0007517 muscle organ development GO:0030198 extracellular matrix organization GO:0031589 cell-substrate adhesion GO:0033627 cell adhesion mediated by integrin GO:0038065 collagen-activated signaling pathway GO:0043062 extracellular structure organization |
Molecular Function |
GO:0005518 collagen binding GO:0038064 collagen receptor activity GO:0098631 protein binding involved in cell adhesion GO:0098634 protein binding involved in cell-matrix adhesion GO:0098639 collagen binding involved in cell-matrix adhesion |
Cellular Component |
GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0008305 integrin complex GO:0030055 cell-substrate junction GO:0034681 integrin alpha11-beta1 complex GO:0043235 receptor complex GO:0098636 protein complex involved in cell adhesion GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04151 PI3K-Akt signaling pathway hsa04510 Focal adhesion hsa04512 ECM-receptor interaction hsa04810 Regulation of actin cytoskeleton |
Reactome |
R-HSA-1474244: Extracellular matrix organization R-HSA-216083: Integrin cell surface interactions |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ITGA11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ITGA11 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ITGA11 in various data sets.
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Points in the above scatter plot represent the mutation difference of ITGA11 in various data sets.
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Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ITGA11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ITGA11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ITGA11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ITGA11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ITGA11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ITGA11 |
Name | integrin, alpha 11 |
Aliases | HsT18964; Integrin alpha-11 |
Chromosomal Location | 15q22.3-q23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ITGA11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |